RETRACTED: Application of Hydrogen Proton Magnetic Resonance Technology Combined with Brain Neurometabolite Analysis in the Treatment of Cognitive Impairment Caused by Type 2 Diabetes Mellitus

Li, Siou; Yin, Changhao; Zhao, Weina; lian, xu bi; Qiao, Hong

doi:10.1016/j.wneu.2019.12.162

Cited by 8 publications

(11 citation statements)

References 8 publications

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“…Diabetes is a group of metabolic syndromes characterized by hyperglycemia. The disturbance of blood glucose can lead to a series of pathogenetic mechanisms involving neurological dysfunction, including neuronal apoptosis, abnormal energy metabolism, synaptic dysfunction, neurodegenerative changes, and oxidative stress in brain tissue (31)(32)(33)(34). Compared with healthy controls, T1DM patients showed fractional anisotropy values in major association fibers of the frontal, parietal, and temporal regions 20 years after diagnosis (35).…”

Section: Discussionmentioning

confidence: 99%

The relationship between diabetes mellitus and attention deficit hyperactivity disorder: A systematic review and meta-analysis

Zhao²,

Liu³

et al. 2022

Front. Pediatr.

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BackgroundThis study aims to investigate the prevalence estimate of diabetes mellitus (DM) among people with attention deficit hyperactivity disorder (ADHD) as well as the prevalence of ADHD among those with DM. In addition, the impact of ADHD on glycemic control in patients with DM was also assessed using a systematic review and meta-analysis of currently available published data.Materials and methodsThe PubMed, Embase, Web of Science, and PsycInfo databases were searched for potential studies. Two reviewers independently selected studies according to the inclusion and exclusion criteria. All pooled analyses were conducted using the random-effects models on Review Manager 5.3.ResultsSeventeen observational studies were included. The pooled results showed an increase in the prevalence of DM among patients with ADHD versus those without ADHD [type 1 DM OR: 1.37 (95% CI: 1.17–1.61); type 2 DM OR: 2.05 (95% CI: 1.37–3.07)]. There was an overall 35% increase in the prevalence of ADHD among patients with type 1 DM [OR: 1.35 (95% CI: 1.08–1.73)]. Children with type 1 DM and ADHD had higher levels of hemoglobin A1c [standardized mean of differences: 0.67 (95% CI: 0.48–0.86)], and prevalence of hypoglycemic and ketoacidosis index compared with those without ADHD.ConclusionOur study revealed the bidirectional associations between ADHD and DM. Patients with ADHD and type 1 DM comorbidities were more likely to have poorer diabetes control. More studies are needed to confirm this association and elucidate the underlying mechanism.

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Section: Discussionmentioning

confidence: 99%

The relationship between diabetes mellitus and attention deficit hyperactivity disorder: A systematic review and meta-analysis

Zhao²,

Liu³

et al. 2022

Front. Pediatr.

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“…In T2DM patients, there was a negative correlation between the NAA value and glycated hemoglobin concentration in the right prefrontal cortex. These results suggested that recent blood glucose levels can affect changes in brain metabolites, and that the reasonable control of blood glucose can effectively delay brain lesions caused by T2DM (38). Cao et al (39) studied the possible metabolic changes in the frontal cortex and parietal WM in patients with diabetic hypertension (DHT).…”

Section: Mrsmentioning

confidence: 99%

A narrative review of multimodal imaging of white matter lesions in type-2 diabetes mellitus

Tang¹,

Li²,

Yang³

et al. 2021

Ann Palliat Med

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Objective: To discuss the relevant studies about the structural and functional changes of the brain in patients with type-2 DM (T2DM) and white matter lesion (WML) in recent years, and to summarize them.Background: T2DM is a common metabolic disease with increasing prevalence worldwide. This disease is closely related to central nervous system and vascular disease, and is considered a risk factor for white matter lesions in the brain. Compared to healthy individuals, WML patients with T2DM exhibit changes in brain perfusion, functional networks, nerve fiber structure, and brain tissue metabolism. Methods:We analyzed recent studies related to structural and functional changes in the brain of patients suffering from T2DM and WML and summarized them.Conclusions: Multimodal magnetic resonance imaging (MRI) utilizes noninvasive and sensitive imaging techniques to provide multiparametric information in patients with T2DM to help in clinical practice. It features non-invasively and with high sensitivity assess the histomorphological and functional abnormalities of white matter in patients with T2DM using various parameters. We can use multimodal MRI methods to reflect the microscopic damage of neuromyelin structures and pathological changes of neuronal metabolic functions in WML in T2DM patients, and thus speculate the disease progression. This approach can be helpful for the early diagnosis and treatment of patients with such a disease who do not exhibit neurological deficit, to effectively improve their prognosis.

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“…Hyperglycemia in diabetes produces nutrient excess in neurons, resulting in abnormal AMPK/PGC-1α (5 -AMP activated protein kinase/peroxisome proliferator-activated receptor γ coactivator-1α) signaling and exhaustion of ATP supply, thereby impairing neural transmission and nerve conduction (Chowdhury et al, 2013). Levels of N-acetylaspartic acid in the right prefrontal cortex are negatively correlated with HbA1c in T2DM (Li et al, 2020), suggesting that blood glucose affects brain metabolite concentrations, which may have an impact on higher neurological activities such as EF. (4) Microvascular complications caused by hyperglycemia and the resulting neurodegenerative changes impair EF.…”

Section: Hyperglycemia Leads To Ef Impairmentmentioning

confidence: 99%

Executive Function and Diabetes: A Clinical Neuropsychology Perspective

et al. 2020

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Objective: Diabetes is a global public health concern. Management of diabetes depends on successful implementation of strategies to alleviate decline in executive functions (EFs), a characteristic of diabetes progression. In this review, we describe recent research on the relationship between diabetes and EF, summarize the existing evidence, and put forward future research directions and applications. Methods: Herein, we provide an overview of recent studies, to elucidate the relationship between DM and EF. We identified new screening objectives, management tools, and intervention targets for diabetes management. We also discuss the implications for clinical practice. Results: In both types 1 and 2 diabetes mellitus (DM), hyperglycemia substantially impairs EF in people of all age groups and ethnicities. Hypoglycemia can similarly impair EF. Interestingly, a decline in EF contributes to DM progression. Glucose dysregulation and EF decline exacerbate each other in a vicious cycle: poor blood glucose control, impaired EF, diabetes management task failure, then back to poor blood glucose control. Many pathophysiological indexes (e.g., obesity, metabolic index, inflammatory and immune factors), neuropsychological indexes (e.g., compliance, eating habits, physical exercise, sleep, and depression), and genetic factors are changed by this pathological interaction between DM and EF. These changes can provide insight into the pathophysiological mechanisms of diabetes-related EF decline. Conclusion: Further studies, including large-scale prospective and randomized controlled trials, are needed to elucidate the mechanism of the interaction between diabetes and EF and to develop novel strategies for breaking this cycle.

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RETRACTED: Application of Hydrogen Proton Magnetic Resonance Technology Combined with Brain Neurometabolite Analysis in the Treatment of Cognitive Impairment Caused by Type 2 Diabetes Mellitus

Cited by 8 publications

References 8 publications

The relationship between diabetes mellitus and attention deficit hyperactivity disorder: A systematic review and meta-analysis

The relationship between diabetes mellitus and attention deficit hyperactivity disorder: A systematic review and meta-analysis

A narrative review of multimodal imaging of white matter lesions in type-2 diabetes mellitus

Executive Function and Diabetes: A Clinical Neuropsychology Perspective

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