RETRACTED: Amino acid based Rosuvastatin cocrystals: Towards the improvement of physicochemical parameters

Vemuri, Venkata Deepthi; Srinivas, Leela

doi:10.1016/j.jcrysgro.2021.126241

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…Synthon engineering can also predict the formation of cocrystals; LGLN has carboxyl and amide groups, while ACF has carboxyl and hydroxyl groups acting as donors or receptors to form hydrogen bonds [18,19]. In addition, LGLN, as a coformer, can form cocrystals with several other APIs [20]. LGLN is also proven to reduce the side effects of flatulence from mesalamine, one of the NSAIDs, by stabilizing acid bases in the digestive tract [18,21].…”

Section: Introductionmentioning

confidence: 99%

Increased Dissolution Rate of Aceclofenac by Formation of Multicomponent Crystals With L-Glutamine

JESSICA,

YASA,

ZAINI

et al. 2024

Int J App Pharm

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Objective: The objectives of this research were to improve the solubility as well as the rate of dissolution of aceclofenac (ACF) through the formation of multicomponent crystals (MCC) with L-glutamine (LGLN) as a coformer and following the liquid-assisted grinding (LAG) technique. Methods: MCC of ACF and LGLN was formed by Liquid Assisted Grinding (LAG) technique. Powder X-ray Diffractometer (PXRD), Differential Scanning Calorimeter (DSC), Fourier Transform Infrared (FT-IR) spectrometer, Particle Size Analyzer (PSA), and Scanning Electron Microscope (SEM) were used for MCC characterization. Solubility and dissolution test were determined using ultraviolet-visible (Uv-Vis( spectrophotometer. Results: The results showed a decrease in the diffraction peak intensity, melting point, and enthalpy of fusion. FT-IR analysis showed a non-significant wavenumber shift compared to intact components. These characterizations showed that MCC formed a eutectic mixture. SEM and particle size analysis showed a homogeneous particle rod shape and decreased particle size. ACF's solubility in MCC increased 2.21 times more than intact form. MCC's dissolution rate increased by 5.34 times and 5.56 times, respectively, after 60 min in phosphate buffer pH 6.8 and CO2-free distilled water. Conclusion: The formation of MCC of ACF and LGLN considerably enhances ACF's solubility and dissolution rate.

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