[Retracted] A New Heterometallic MOF in Cyanosilylation Reaction, Treatment and Care Management Value in Stroke by Reducing Oxidative Stress Damage

Abstract

By employment the heterometallic strategy, a new highly porous metal-organic framework {(Me2NH2)[Mn3K2(TZIA)3(H2O)3]·(DMF)4}n (1) was prepared via corresponding K(I)and Mn(II) salts and hetero-donor organic ligand 5-(1H-tetrazol-5-yl)isophthalic acid (H3TZIA) via solvothermal conditions in water and DMF mixed solvent. X-ray study of a single crystal shows that ionic K+ was immobilized on the surface of pores via trinuclear Mn2+–tetrazole coordination motif. The resulting activated 1a has been explored in detail by BET analysis to probe its porosity. The removal of water molecules in order to generate 1a makes it possible for K+ ions to be applied as an efficient and size-selective multiphase catalyst for cyanosilylation of acetaldehyde under the mild conditions without solvent. Furthermore, ELISA assay was performed to measure IL-18 and IL-1β level in hCMEC/D3 human brain microvascular endothelial cells after compound treatment. Besides, ROS detection and RT-PCR was performed to detect ROS production as well as the related gene expression. Next, the protective effect of the compound was evaluated in animal model in vivo.

Oxi-Redox Selective Breast Cancer Treatment: An In Vitro Study of Theranostic In-Based Oxide Nanoparticles for Controlled Generation or Prevention of Oxidative Stress

“…[5][6][7] Therefore, a controlled ROS prevention may reduce the incidence of the ROS-involved diseases. [8][9][10] Nevertheless, ROS is a double-edge sword; cellular production of ROS plays a very significant positive role in physiological responses in a number of cases including cell redox signaling, cell homeostasis, and cellular apoptosis (programmed cell death), 2,[11][12][13] where induction of cellular apoptosis in cancer cells has become a conventional strategy in nanomedicine for cancer therapy.…”

“…Excessive ROS that cannot be eliminated by the biological antioxidant system will lead to oxidative stress damage to all cell components, including protein oxidation, lipid peroxidation, and DNA damage. − It has been revealed that oxidative stress is involved in many human diseases, including Alzheimer’s disease, Parkinson’s disease, strokes, diabetes, inflammation disorders, cancer, and so on. − Therefore, a controlled ROS prevention may reduce the incidence of the ROS-involved diseases. − Nevertheless, ROS is a double-edge sword; cellular production of ROS plays a very significant positive role in physiological responses in a number of cases including cell redox signaling, cell homeostasis, and cellular apoptosis (programmed cell death), ,− where induction of cellular apoptosis in cancer cells has become a conventional strategy in nanomedicine for cancer therapy.…”