Oxi-Redox Selective Breast Cancer Treatment: An In Vitro Study of Theranostic In-Based Oxide Nanoparticles for Controlled Generation or Prevention of Oxidative Stress

Hsu, Nai Sheng; Tehei, Moeava; Hossain, Shahriar A.; Rosenfeld, Anatoly B.; Shiddiky, Muhammad J. A.; Sluyter, Ronald; Dou, Shi Xue; Yamauchi, Yusuke; Konstantinov, Konstantin

doi:10.1021/acsami.0c17326

Cited by 7 publications

(14 citation statements)

References 68 publications

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“…A H 2 DCFDA probe was employed to study the change in ROS concentration [ 188 ]. The results of this study show a decrease in ROS level at a concentration of 0.05 mM of La +3 [ 157 ]. Wang et al reported the ROS scavenging mechanism and protection effect against oxidative stress in soybean seeds [ 189 ].…”

Section: Oxygen-deficient Lanthanum Oxidementioning

confidence: 96%

“…In many studies, ITO was reported as a substrate layer with other metal oxide NPs (such as ZnO, Au, Ag, Pt, Ni, Fe 2 O 3 NPs) for the development of biosensors for a range of biomedical applications [ 156 ]. Recently, ITO NPs have been reported by Hsu et al as theranostic agents for the treatment of cancer, Figure 10 [ 157 ]. Oxygen-deficient ITO NPs were prepared by the chemical precipitation method, followed by calcination at 400 °C [ 157 ].…”

Section: Indium Tin Oxide (Ito) Nanostructure In the Biological Fieldmentioning

confidence: 99%

“…Recently, ITO NPs have been reported by Hsu et al as theranostic agents for the treatment of cancer, Figure 10 [ 157 ]. Oxygen-deficient ITO NPs were prepared by the chemical precipitation method, followed by calcination at 400 °C [ 157 ]. The modification of the surface structure affects the physiochemical properties of NPs.…”

Section: Indium Tin Oxide (Ito) Nanostructure In the Biological Fieldmentioning

confidence: 99%

“…ITO NPs can be employed in biomedical imaging due to their intrinsic fluorescent properties. The band gap and quantum size effect can also play important roles in the fluorescent-related imaging of ITO [ 157 , 158 , 159 ].…”

Section: Indium Tin Oxide (Ito) Nanostructure In the Biological Fieldmentioning

confidence: 99%

“…The reported in vitro cytotoxicity study of ITO NPs on human epithelial (MDA-MB-231) cells, breast cancer (MCF-7) cells and human epithelial (MCF-10A) normal breast cells is summarised in Table 6 , and the mechanism is shown in Figure 11 [ 157 ]. According to the results, ITO NPs induced selective toxicity in MDA-MB-231 and MCF-7 cell lines by ROS generation, which caused higher oxidative stress in comparison to non-malignant MCF-10A cell lines, shown in Figure 10 b,c.…”

Section: Indium Tin Oxide (Ito) Nanostructure In the Biological Fieldmentioning

confidence: 99%

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Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

et al. 2022

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The development of smart, efficient and multifunctional material systems for diseases treatment are imperative to meet current and future health challenges. Nanomaterials with theranostic properties have offered a cost effective and efficient solution for disease treatment, particularly, metal/oxide based nanotheranostic systems already offering therapeutic and imaging capabilities for cancer treatment. Nanoparticles can selectively generate/scavenge ROS through intrinsic or external stimuli to augment/diminish oxidative stress. An efficient treatment requires higher oxidative stress/toxicity in malignant disease, with a minimal level in surrounding normal cells. The size, shape and surface properties of nanoparticles are critical parameters for achieving a theranostic function in the microenvironment. In the last decade, different strategies for the synthesis of biocompatible theranostic nanostructures have been introduced. The exhibition of therapeutics properties such as selective reactive oxygen species (ROS) scavenging, hyperthermia, antibacterial, antiviral, and imaging capabilities such as MRI, CT and fluorescence activity have been reported in a variety of developed nanosystems to combat cancer, neurodegenerative and emerging infectious diseases. In this review article, theranostic in vitro behaviour in relation to the size, shape and synthesis methods of widely researched and developed nanosystems (Au, Ag, MnOx, iron oxide, maghemite quantum flakes, La2O3−x, TaOx, cerium nanodots, ITO, MgO1−x) are presented. In particular, ROS-based properties of the nanostructures in the microenvironment for cancer therapy are discussed. The provided overview of the biological behaviour of reported metal-based nanostructures will help to conceptualise novel designs and synthesis strategies for the development of advanced nanotheranostic systems.

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Section: Oxygen-deficient Lanthanum Oxidementioning

confidence: 96%

Section: Indium Tin Oxide (Ito) Nanostructure In the Biological Fieldmentioning

confidence: 99%

Section: Indium Tin Oxide (Ito) Nanostructure In the Biological Fieldmentioning

confidence: 99%

Section: Indium Tin Oxide (Ito) Nanostructure In the Biological Fieldmentioning

confidence: 99%

Section: Indium Tin Oxide (Ito) Nanostructure In the Biological Fieldmentioning

confidence: 99%

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Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

et al. 2022

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Peptide-nanoparticle conjugates as a theranostic platform

Kim,

No,

Sluyter

et al. 2024

Coordination Chemistry Reviews

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Multienzymatic Antioxidant Activity of Manganese-Based Nanoparticles for Protection against Oxidative Cell Damage

Zhang

Chen

Sun

et al. 2022

ACS Biomater. Sci. Eng.

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Oxidative stress is related to many diseases, but available clinical treatment methods are currently limited. Exploitation of enzyme-mimicking nanomaterials (nanozymes) is a promising way for scavenging reactive oxygen species (ROS) and treatment of ROS-related diseases. Herein, the catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GP x ) mimicking activities are expressed by MnO2 nanoparticles (MnO2 –BSA NPs) coated with BSA. Effective •OH removal activity is also expressed by MnO2 –BSA NPs at neutral pH. Apoptosis inhibition and ROS scavenging capabilities of MnO2 –BSA NPs are evident on the H2O2-exposed BEAS-2B cells line. Western blot analysis indicates that MnO2 –BSA NPs inhibit H2O2-induced apoptosis by mediating the expression of apoptosis-related proteins.

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Oxi-Redox Selective Breast Cancer Treatment: An In Vitro Study of Theranostic In-Based Oxide Nanoparticles for Controlled Generation or Prevention of Oxidative Stress

Abstract: capability towards anatomical contrast enhancement. These results suggest that the synthesized ITO NPs have the potential to be a novel selective therapeutic agent with a multimodal imaging property for anticancer treatment.

Cited by 7 publications

References 68 publications

Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

Peptide-nanoparticle conjugates as a theranostic platform

Multienzymatic Antioxidant Activity of Manganese-Based Nanoparticles for Protection against Oxidative Cell Damage

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