Retinopathy of Prematurity (Rop);

Ali, Muhammad Asghar; Anwar, Muhammad; Naeem, Malik Muhammad

doi:10.29309/tpmj/2019.26.04.3375

Cited by 3 publications

(5 citation statements)

References 6 publications

(7 reference statements)

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“…A significant relationship between birth weight and ROP was also confirmed by multivariate logistic regression analysis by which birth weight less than 1725 g was associated with a 4.5-fold increase in the risk of ROP (OR = 4.522, 95% CI: 2.677-7.637, P <0.001). This finding is consistent with many previous studies (4,(11)(12)(13)16,17,19).…”

Section: Discussionsupporting

confidence: 94%

“…ROP is a multifactorial disease in which low gestational age at birth has been suggested in several studies as an important risk factor for this disease. In studies in India, Pakistan, Mexico, Portugal, Oman, and Isfahan, the gestational age of neonates with retinopathy at birth was significantly lower than that of nonpatients (4,11,13,14,16,17), which are in accordance with our findings. In a study by Ludwig et al (2017) in the United States, multivariate regression analysis showed that gestational age was an independent predictor of ROP (12), which is similar to the present study.…”

Section: Discussionsupporting

confidence: 92%

“…While its prevalence in the study of Acevedo-castelln et al (2019) in Mexico was 56.1%, followed by 40.4% in Oman, 34% in Egypt, 33% in Pakistan, and 31.3% in Portugal. All are more than the present study (13)(14)(15)(16)(17). The prevalence of ROP in Saudi Arabia has been reported to be 28%, which is similar to our findings (18).…”

Section: Discussionmentioning

confidence: 58%

“…In countries where consanguineous marriage is common, there are few studies that have assessed this issue, among which, Naderian et al (2010) in Isfahan reported no significant relationship between the consanguineous parental marriage and ROP, which is contrary to our findings (4), but a study by Gharaibeh et al (2011) in Jordan, similar results were reported, where the frequency of consanguineous marriage was higher among ROP than premature infants who did not have retinopathy (19.2% vs 1.9%; p=0.007), (25). There is some indirect evidence for the influence of genetic components on the pathogenesis of ROP along with several other risk factors that have been proposed in various studies for this disease.for example, the prevalence of the disease has been reported to be more common in whites than in blacks or in boys more than girls (16,26). It is thought that certain genetic polymorphisms may be due to the function of genes such as vascular endothelial growth factor (VEGF), which control retinal vascularization, and thus be involved in the pathogenesis of ROP (27,28).…”

Section: Discussionmentioning

confidence: 97%

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Retinopathy of prematurity (ROP) in Ardebil (North West of Iran): Prevalence and Risk factors

Ojaghi¹,

Fekri²,

Momeni³

et al. 2021

PJMHS

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Background and objective: Retinopathy of prematurity (ROP), which affects the retina of premature infants, is a leading cause of blindness in premature infants worldwide. The aim of this study was to evaluate the frequency and risk factors of retinopathy of prematurity infants referred to Alavi hospital between October 2018 and October 2019. Methods: In the present study, 400 infants with gestational age less than 34 weeks and or birth weight of 2000 g or less were enrolled in the study. Required information including sex, gestational age, maternal age, birth weight, type of delivery, oxygen therapy, septicemia, multiple gestations, family marriage, respiratory problem, and blood exchange were extracted from their hospital records and then included in the data collection form. These infants were also examined for ROP, stage and area of involvement by an experienced ophthalmologist and then classified into two groups including retinopathy and healthy group. Finally, the data were analyzed in SPSS 25 software using chi-square, fisher exact test, t-test, binary logistic regression, and ROC curve analysis. Results: Of the 400 preterm infants studied (57.2% male and 42.8% female), 107 (26.8%) infants had ROP of whom 23 (21.5%) needed treatment (i.e. 5.8% of all infants need treatment). There were 4 (3.7%), 29 (27.1%), and 74 (69.2%) infants with zone I, II, and III, respectively. There were 91 (85%), 11 (10.3%), and 5 (4.7%) infants with stage I, II, and III, respectively. Multivariate logistic regression analysis showed that parental consanguinity (OR=2.263, 95%CI: 1.240-4.130, P=0.008), gestational age less than 32.5 weeks (OR=4.067, 95%CI: 2.340- 7.069, P<0.001), and birth weight less than 1725 g (OR=4.522, 95%CI: 2.677-7.637, P<0.001) were associated with a 2.3-fold, 4.1-fold, and 4.5-fold increased risk of ROP, respectively. ROP had no significant relationship with other variables. Conclusion: In summary, the findings of the present study showed that one quarter of the premature infants had ROP. Furthermore, birth weight less than 1725 g, gestational age less than 32.5 weeks, and parental consanguinity were risk factors for ROP, in addition, one-fifth of the infants with ROP needed treatment. Key Words: Retinopathy, Prematurity, ROP, Newborn.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Retinopathy of prematurity (ROP) in Ardebil (North West of Iran): Prevalence and Risk factors

Ojaghi¹,

Fekri²,

Momeni³

et al. 2021

PJMHS

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“…In contrast,Ali et al, [10] found that, male sexual orientation was incorporated among hazard factors for serious, treatment-requiring ROP, birth head perimeter, birth length were fundamentally connected to ROP requiring treatment.…”

Section: Discussionmentioning

confidence: 94%

Early Postnatal Prediction of Retinopathy of Prematurity in Preterm Newborns in Neonatal Intensive Care Units

2020

Benha Journal of Applied Sciences

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Retinopathy of Prematurity is an issue of the preterm infant portrayed by neurovascular interruption in the juvenile retina that may cause visual hindrance and visual deficiency. This examination planned to build up a screening device for early postnatal forecast of Retinopathy of Prematurity (ROP) in preterm infants dependent on danger factors inside the principal 48h of postnatal life. This examination was led on 200 preterm children admitted to NICU , Benha college Hospital and Nasser General Hospital in Shobra. All children were exposed to full history taking and complete clinical assessment. Fundus assessment by roundabout ophthalmoscope and computerized imaging of chosen cases were finished. There was critical factual increment of ROP among lower GA and BW (P<0.001). There was critical measurable increment of ROP in prematures with maternal history of chorioamnionitis and antenatal steroids adminstration (P<0.001). There was huge factual increment of ROP among youngsters with sepsis (P<0.001). The frequency of ROP in our investigation was 4.5%. Both birth weight at cutoff point <1.5 Kg and gestational age at cutoff point <33.5 wks had high affectability and particularity in expectation of ROP.

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Retinopathy of prematurity in Ardabil, North West of Iran: Prevalence and risk factors

et al. 2021

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Retinopathy of prematurity (ROP), which affects the retina of premature infants, is a leading cause of blindness in premature infants worldwide. The aim of this study was to evaluate the frequency and risk factors of retinopathy of prematurity infants referred to Alavi hospital between October 2018 and October 2019. In the present study, 400 infants with gestational age less than 34 weeks and or birth weight of 2000 g or less were enrolled in the study. Required information including sex, gestational age, maternal age, birth weight, type of delivery, oxygen therapy, septicemia, multiple gestations, consanguineous marriage, respiratory problem, and blood exchange were extracted from their hospital records and then included in the data collection form. These infants were also examined for ROP, stage and area of involvement by an experienced ophthalmologist and then classified into two groups including retinopathy and healthy group. Finally, the data were analyzed in SPSS 25 software using chi-square, fisher exact test, t-test, binary logistic regression, and ROC curve analysis. Of the 400 preterm infants studied (57.2% male and 42.8% female), 107 (26.8%) infants had ROP of whom 23 (21.5%) needed treatment (i.e. 5.8% of all infants need treatment). There were 4 (3.7%), 29 (27.1%), and 74 (69.2%) infants with zone I, II, and III, respectively. There were 91 (85%), 11 (10.3%), and 5 (4.7%) infants with stage I, II, and III, respectively. Multivariate logistic regression analysis showed that parental consanguinity (OR=2.263, 95%CI: 1.240-4.130, P=0.008), gestational age less than 32.5 weeks (OR=4.067, 95%CI: 2.340-7.069, P<0.001), and birth weight less than 1725 g (OR=4.522, 95%CI: 2.677-7.637, P<0.001) were associated with a 2.3-fold, 4.1-fold, and 4.5-fold increased risk of ROP, respectively. ROP had no significant relationship with other variables. In summary, the findings of the present study showed that one quarter of the premature infants had ROP. Furthermore, birth weight less than 1725 g, gestational age less than 32.5 weeks, and parental consanguinity were risk factors for ROP, in addition, one-fifth of the infants with ROP needed treatment.

show abstract

Retinopathy of Prematurity (Rop);

Cited by 3 publications

References 6 publications

Retinopathy of prematurity (ROP) in Ardebil (North West of Iran): Prevalence and Risk factors

Retinopathy of prematurity (ROP) in Ardebil (North West of Iran): Prevalence and Risk factors

Early Postnatal Prediction of Retinopathy of Prematurity in Preterm Newborns in Neonatal Intensive Care Units

Retinopathy of prematurity in Ardabil, North West of Iran: Prevalence and risk factors

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