Retinopathy of prematurity in Rwanda: a prospective multi-centre study following introduction of screening and treatment services

Cannoodt, Luk; Casteels, Ingele; Conard, Craig; Smedt, Stefan De; Devlieger, Hugo; Fonteyne, Yannick; Gilbert, Clare; Gisagara, Egide; Kumwami, Muzungu; Mudereva, Godelieve; Muhizi, Charles; Karemazi, Gustave Mulindwa; Musiime, Stephenson; Mutangana, Francis; Mutsinzi, Edison; Ngambe, Tharcisse; Noë, Piet; Nsabimana, Hovaire; Nyemazi, Alex; Sebuseruka, Sonia; Theophile, Tuyisabe; Tuyisenge, Lisine; Uwurukundo, Marie Claude; Kerschaver, Erwin Van

doi:10.1038/s41433-019-0529-5

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…The incidence of ROP in our hospital at 21% is higher than earlier reports from Ibadan, Nigeria (12.2%),[ 1 ] Lagos, Nigeria (15%),[ 17 ] Ghana (13.7%),[ 18 ] Rwanda (7.3%),[ 8 ] but much less than the 30% reported from Iran,[ 19 ] Port Harcourt, Nigeria (47.2%),[ 4 ] Kenya (41.7%),[ 20 ] and Oman (46.4%). [ 21 ] However, the incidence recorded in this report is similar to the 19.2% reported in Egypt.…”

Section: Discussioncontrasting

confidence: 62%

“…[ 1 ] The study in Egypt[ 22 ] included infants with higher GA (>32 weeks) and BW (up to 2000 g), whereas the mean age in the ROP group in a study in Rwanda is somewhat similar to that in the index study at 30.1 weeks. [ 8 ] However, reasons for the variances in the incidences of ROP from these different studies can be alluded to the difference in the GA used, in addition to other yet-to-be determined factors.…”

Section: Discussionmentioning

confidence: 99%

“…With the increasing survival rates of preterm babies in middle-income countries, screening for ROP is even more important for these groups of high-risk babies. [ 8 9 ]…”

Section: Introductionmentioning

confidence: 99%

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Retinopathy of prematurity in the University of Calabar Teaching Hospital, Calabar, Nigeria: An early report of a screening service

Udoh

Nkanga

Agweye

et al. 2021

J West Afr Coll Surg

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Background: Retinopathy of prematurity (ROP) is an important cause of childhood blindness worldwide. This blindness is avoidable through regular screening of preterm infants and prompt intervention for those with the condition. Aims/Objectives: This study aimed to determine the pattern of presentation of ROP and the risk factors for its development among preterm infants in the Neonatal Unit of the University of Calabar Teaching Hospital, Calabar, Nigeria. Design of Study: This study is a prospective, longitudinal study. Settings: The study was carried out in the Special Care Baby Unit, Sick Baby Unit, and Neonatal Clinic of the Department of Paediatrics and Child Health, University of Calabar Teaching Hospital, Calabar, Nigeria. Materials and Methods: All preterm infants whose mothers had given informed consent to participate were enrolled. Ocular examination was performed by a trained ophthalmologist. ROP was staged and documented using the revised version of the International Classification of ROP. Data were entered into a questionnaire and analysed using IBM SPSS version 22. Results: Of the 53 neonates recruited into the study, ROP was detected in 11 (21%) neonates, of which 9 (82%) had stage 1 disease, 2 (18%) had stage 2, and none had stage 3. ROP was more common in females, 7 (63.6%), than their male counterparts 4 (36.4%). ROP was higher among those with gestational age (GA) ≤30 weeks [9 (81.8%)] when compared with those with GA >30 weeks [2 (18.2%)] ( P = 0.016). Other risk factors for ROP assessed by this study were found not to be significantly associated with the occurrence of ROP. Conclusion: ROP was present in 21% of the neonates, and the majority had stage 1 disease. This finding emphasizes the need for screening of all preterm neonates for ROP in order to forestall avoidable blindness which could result from this condition.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Retinopathy of prematurity in the University of Calabar Teaching Hospital, Calabar, Nigeria: An early report of a screening service

Udoh

Nkanga

Agweye

et al. 2021

J West Afr Coll Surg

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“…The result of this study has shown that oxygen therapy for more than seven days had been signi cant for ROP development (P=0.049). Similarly study done by F. Mutangana et al (32), Akkawi (30),and by Cut Badriah (24); had also shown that oxygen therapy had signi cant association for the development of ROP (p<0.05).…”

Section: Discussionmentioning

confidence: 54%

Prevalence and Risk Factors For Retinopathy of Prematurity Among Infants in Minilk-II Hospital, Addis Ababa, Ethiopia: A Retrospective Cross-Sectional Study, 2020.

Woldemariam

Aliyou

Redi

2021

Preprint

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Background: Retinopathy of prematurity (ROP) is defined as a vaso-proliferative retinal disorder that leads to childhood blindness; and persists as the main cause of preventable childhood blindness. The impact of ROP in developing countries is heavier as term infants can develop ROP because of inadequate awareness of the disease development and the risk factors. Hence, the aim of the study is assessing the prevalence and risk factors for retinopathy of prematurity in the specific study area.Methodology: An institutional based cross-sectional retrospective study was conducted on 301 samples of the pediatrics out-patient eye clinic medical records, at Minilik II referral hospital, from March to April 2020. Study subjects were selected using systematic random sampling method. Data was collected from medical records of all infants visiting the hospital for eye problems from January 2018 to December 2019, using a structured check list. The collected data was entered and cleaned using Epi data 6.4.2.0 and then exported & analyzed using SPSS version 25. Bivariate and multivariate analysis was computed to distinguish the statistically significant factors. Result: The prevalence of ROP among infants in this study showed 39(13%). Of these, more than half (56.4%) were Zone II + Stage 1, followed by Zone II + stage-2, and Stage-5; 12.8% and 10.2% respectively. Birth weight, oxygen therapy and sepsis were the factors significantly associated with ROP [AOR= 39.28; 95% CI: 3.204- 481.658], [AOR= 5.317; 95% CI:1.009- 28.019] and [AOR=9.805; 95% CI:1.592- 60.388] respectively. Conclusions: the prevalence of ROP in the current study is (13%). Birth weight, oxygen therapy and sepsis were the determinant risk factors for development of ROP. Regular ANC, and maternal education may be important to reduce the risk of low-birth weight, and sepsis that results in long-term oxygen therapy leading to childhood blindness.

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“…Infants who receive unrestricted oxygen in units without the capacity to blend oxygen/air are at increased risk of developing severe ROP [4]. This may contribute to the observations from previous studies that larger and/or more mature infants (≥1500 g and/or ≥32 weeks gestational age) are developing ROP in sub-Saharan Africa [18][19][20][21][22][23][24][25]. A compressed oxygen source was available in every unit, but many units did not have the capacity to blend oxygen/air because of lack of compressed medical air, precluding the use of traditional blenders.…”

Section: Discussionmentioning

confidence: 98%

Oxygen management among infants in neonatal units in sub-Saharan Africa: a cross-sectional survey

et al. 2021

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Objectives To provide more comprehensive data on the management of oxygen supplementation in neonates in sub-Saharan Africa.Study design An online survey on the management of oxygen supplementation for infants in neonatal units was sent to 278 healthcare personnel in sub-Saharan Africa.Results One hundred and nine responses from 82 neonatal care units in 54% (26/48) sub-Saharan African countries were received. All units had the capacity to provide oxygen supplementation. However, only 50% (38/76) had access to blend oxygen with medical air and 1% (1/75) had the capacity to blend oxygen/air for every infant. Although 96% (72/75) of units could monitor oxygen saturation, monitoring was mostly intermittent and only 32% (24/75) were able to monitor oxygen saturation in every infant receiving oxygen supplementation. Conclusions Findings indicate that oxygen supplementation is inadequately managed in neonatal units in sub-Saharan Africa, which may put infants at risk of developing severe ROP.

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Retinopathy of prematurity in Rwanda: a prospective multi-centre study following introduction of screening and treatment services

Cited by 11 publications

References 31 publications

Retinopathy of prematurity in the University of Calabar Teaching Hospital, Calabar, Nigeria: An early report of a screening service

Retinopathy of prematurity in the University of Calabar Teaching Hospital, Calabar, Nigeria: An early report of a screening service

Prevalence and Risk Factors For Retinopathy of Prematurity Among Infants in Minilk-II Hospital, Addis Ababa, Ethiopia: A Retrospective Cross-Sectional Study, 2020.

Oxygen management among infants in neonatal units in sub-Saharan Africa: a cross-sectional survey

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