Retinopathy of prematurity: are we screening too many babies?

Mathew, Mariam; Fern, A I; Hill, Robert G.

doi:10.1038/sj.eye.6700031

Cited by 49 publications

(47 citation statements)

References 20 publications

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“…While we adopt the Royal College Recommendations of screening infants less than 1500 g, we are in agreement with studies [13][14][15] that recommend lowering the BW criterion for screening infants for ROP to 1250 g. None of our patients over 1250 g developed tROP. This would have decreased the number of babies screened by 38% in our study.…”

Section: Eyesupporting

confidence: 82%

Retinopathy of prematurity in South Africans at a tertiary hospital: a prospective study

Mayet

Cockinos

2005

Eye

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Background and Objectives World Health Organization's vision 20/20 programme has recognized retinopathy of prematurity (ROP) as an important cause of childhood blindness in industrialized and middle-income countries. While ROP is virtually nonexistent in many African countries, ROP is seen in urban areas where facilities for neonatal care exist. The aim of this study is to establish the frequency of ROP in a cohort of patients screened for ROP and to establish if current screening criteria apply to our patients. Patients and Methods Infants with birth weight (BW) of 1500 g or less and/or gestational age of 32 weeks or less were screened for ROP over a 2 1 2 Àyear period by a single examiner. Results ROP was observed in 84 of 514 (16.3%) of infants included for analysis. Threshold disease (tROP) was noted in 1.6% of the total cohort although 41/84 babies with ROP were lost prior to regression or progression to tROP. Of the 43/84 adequately followed up, eight (18.6%) developed tROP. An estimated frequency of tROP was more likely to be 2.9%. There was no tROP noted in babies of BW greater than 1250 g. Gestational age was an unreliable risk parameter in our population. Conclusion The projected occurrence rate of tROP is similar to that found in black population in the Multicentre Cryotherapy for ROP Trial. Our data suggest that the screening criterion based on BW can safely be lowered to 1250 g in our population.

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Section: Eyesupporting

confidence: 82%

Retinopathy of prematurity in South Africans at a tertiary hospital: a prospective study

Mayet

Cockinos

2005

Eye

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“…Recently, both retrospective and prospective studies have reported the frequency and severity of ROP in a wide range varying from hospital to hospital and from population to population (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42). There are limited number of prospective, multicenter studies performed in different populations.…”

Section: Discussionmentioning

confidence: 99%

Bir devlet hastanesinde çok düşük doğum ağırlıklı yenidoğanlarda hastalık ve ölüm oranları

Canbak¹,

Şehitoğlu²,

Dorum³

et al. 2011

tpa

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T Th he e r ra at ti io o o of f m mo or rt ta al li it ty y a an nd d m mo or rb bi id di it ty y i in n v ve er ry y l lo ow w b bi ir rt th h w we ei ig gh ht t i in nf fa an nt ts s i in n a a p pu ub bl li ic c h ho os sp pi it ta al l S Su um mm ma ar ry yAim: Patients were retrospectively analysed to determine mortality and morbidity rates in very low birth weight infants in the neonatal intensive care unit (NICU) in our hospital. Material and Method:In this study 94 very low birth weight premature babies who were hospitalized in our NICU in the last two years and were compatible with our study criteria were evaluated. The input data (gestational age, birth weight, perinatal risk factors, hospital stay, surfactant therapy, mechanical ventilation strategies, respiratory distress syndrome, intraventricular hemorrhage, periventricular leukomalacia, necrotizing enterocolitis, chronic lung disease and retinopathy of prematurity) of these babies were recorded and analyzed statistically. Results:In our study the mortality ratio of very low birth weight babies was found to be 25.5%. The most common maternal risk factor was preeclampsia/eclampsia (%26.3) which was compatible with the data of NICHD Neonatal Network Group.The ratio of RDS was found to be 100% in group 1, 93.8% in group 2, 78.3% in group 3 and 47.6% in group 4. There was no significant difference between RDS(+) and RDS(-) groups in terms of gender distribution (p=0,191). However probability of RDS in male premature babies was found to be 1.81 fold (0.74-4.42) higher than female premature babies. Conclusions:We expect that the mortality ratio which we found to be 25.5% in our NICU will improve parallel to the improvements in prenatal care, decrease in neonatal infections which we frequently face because of deficient prenatal care and improvement in transportation conditions as well as with an increase in steroid usage. (Turk Arch Ped 2011; 46: 137-43)

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“…She did not require re-ventilation and had not suffered prolonged anoxic or hyperoxic states both of which are known to be associated with ROP. 10,11 Other perinatal factors were hyponatremia, hypoglycaemia, conjugated hyperbilirubinemia, compensated acute renal failure, bilateral intraventricular haemorrhage and staphylococcal sepsis. These features are not uncommon in preterm babies and have not found to be independent risk factors in the development of ROP.…”

Section: Discussionmentioning

confidence: 99%

“…11,12 Though birth weight and GA are the two most important independent risk factors for this disease, not all factors contributing to the cause of ROP are yet known. The desire to decrease the number of unaffected babies to be screened should not prevent us from missing some of those cases that may provide valuable insight into the pathogenesis of this disease.…”

Section: Discussionmentioning

confidence: 99%