Retinopathy of Prematurity: A Global Perspective and Recent Developments

Sabri, Kourosh; Ells, Anna L.; Lee, Elizabeth Y; Dutta, Sourabh; Vineker, Anand

doi:10.1542/peds.2021-053924

Cited by 54 publications

(37 citation statements)

References 139 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, this regional change is intriguing, as the blood vessels of infants with ROP reach the nasal ora serrata but leave a gap in the temporal edge, called Zone III. 63 The current thinking is that the avascular area is linked to gestational age because there is an abrupt stop of angiogenesis at birth. 64 It is also possible that regional control of vascular growth occurs, which may be understood by knowing the molecular pathways controlled by regionally expressed factors, such as TBX3.…”

Section: Discussionmentioning

confidence: 99%

Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease

Derbyshire

Akula

Wong

et al. 2023

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Purpose Familial exudative vitreoretinopathy (FEVR) and Norrie disease are examples of genetic disorders in which the retinal vasculature fails to fully form (hypovascular), leading to congenital blindness. While studying the role of a factor expressed during retinal development, T-box factor Tbx3 , we discovered that optic cup loss of Tbx3 caused the retina to become hypovascular. The purpose of this study was to characterize how loss of Tbx3 affects retinal vasculature formation. Methods Conditional removal of Tbx3 from both retinal progenitors and astrocytes was done using the optic cup-Cre recombinase driver BAC-Dkk3-Cre and was analyzed using standard immunohistochemical techniques. Results With Tbx3 loss, the retinas were hypovascular, as seen in patients with retinopathy of prematurity (ROP) and FEVR. Retinal vasculature failed to form the stereotypic tri-layered plexus in the dorsal–temporal region. Astrocyte precursors were reduced in number and failed to form a lattice at the dorsal–temporal edge. We next examined retinal ganglion cells, as they have been shown to play a critical role in retinal angiogenesis. We found that melanopsin expression and Islet1/2-positive retinal ganglion cells were reduced in the dorsal half of the retina. In previous studies, the loss of melanopsin has been linked to hyaloid vessel persistence, which we also observed in the Tbx3 conditional knockout (cKO) retinas, as well as in infants with ROP or FEVR. Conclusions To the best of our knowledge, these studies are the first demonstration that Tbx3 is required for normal mammalian eye formation. Together, the results provide a potential genetic model for retinal hypovascular diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease

Derbyshire

Akula

Wong

et al. 2023

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…16 Although expanding care for these patients in a cost-effective manner is difficult, recent innovations in technologies, such as artificial intelligence and teleretinal screening, have shown promise. 17–19…”

Section: Discussionmentioning

confidence: 99%

A Multicenter Study of Retinopathy of Prematurity Follow-Up Adherence

Mahmud

Karmouta

Strawbridge

et al. 2023

Retina

View full text Add to dashboard Cite

Purpose: Characterize clinical and socioeconomic factors that impact follow-up to complete retinal vascularization and subsequent pediatric ophthalmology follow-up in neonates with retinopathy of prematurity. Methods: Medical records of 402 neonates diagnosed with retinopathy of prematurity from neonatal intensive care units at the University of California, Los Angeles Mattel Children's Hospital and the University of California, Los Angeles Santa Monica Hospital, both academic medical centers, and the Harbor-University of California, Los Angeles Medical Center, a safety-net county hospital, were reviewed. Primary study outcomes were the rate of follow-up to complete retinal vascularization and adequate pediatric ophthalmology follow-up. Secondary outcome was the rate of nonretinal ocular comorbidity. Results: In whole-cohort analysis, 93.6% of neonates were followed to complete retinal vascularization, and 53.5% had adequate pediatric ophthalmology follow-up. Public insurance was associated with lower rates of pediatric ophthalmology follow-up (Odds ratio 0.66, 95% confidence interval 0.45–0.98, P = 0.04). Participants screened at the academic medical center had lower rates of pediatric ophthalmology follow-up compared with the safety-net county hospital (50.7% vs. 63.5%, P = 0.034). In subgroup analysis, academic medical center participants with public insurance were less likely to have pediatric ophthalmology follow-up than safety-net county hospital participants with public insurance (36.5% vs. 63.8%, P < 0.001) or those with private insurance at the academic medical center (36.5% vs. 59.2%, P< 0.001). Conclusion: This study identified high follow-up rates to complete retinal vascularization, lower pediatric ophthalmology follow-up rates, and nonretinal ocular comorbidity at all hospitals. Insurance status relative to hospital type was identified as a risk factor for loss to follow-up. This demonstrates a need to further study health care disparities in retinopathy of prematurity infants.

show abstract

“…The primary outcome was the composite neonatal morbidity, including bronchopulmonary dysplasia, [ 14 ] intraventricular hemorrhage, [ 15 ] periventricular leukomalacia, [ 16 ] necrotizing enterocolitis, [ 17 ] late-onset sepsis, [ 18 ] and retinopathy of prematurity. [ 19 ] We followed up the preterm infants to their term-equivalent age. These data were obtained from the neonatal charts and confirmed by the neonatology physician.…”

Section: Methodsmentioning

confidence: 99%

Cesarean delivery was associated with low morbidity in very low birth weight infants: A retrospective cohort study

Zhu

et al. 2023

Medicine

View full text Add to dashboard Cite

To estimate the relationship among the cesarean delivery (CD), mortality and morbidity in very low birth weight (VLBW) infants weighing less than 1500 g. This retrospective cohort study enrolled 242 VLBW infants delivered between the 24 to 31week of gestation from 2015 to 2021. We compared CD with vaginal delivery (VD). The primary outcome was a composite neonatal morbidity including bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalacia, necrotizing enterocolitis, late-onset sepsis and retinopathy of prematurity. The secondary outcome included mortality within 28 days. A multivariate logistic regression was used and adjusted for birthweight, twin pregnancy and antenatal steroids intake. The overall CD rate was 80.6%. Compared with VD, a significantly lower composite neonatal morbidity was associated with CD (adjusted odds ratio, 0.33, 95% confidence interval, 0.12–0.90, P = .031). The relationship between CD and neonatal morbidity disappeared when the VLBW infants were stratified according to the gestational age. No significant difference was observed between the VD and CD cohorts regarding mortality. Compared with VD, CD was associated with a lower morbidity in VLBW infants. Further studies are required to clarify how this association is influenced by gestational age.

show abstract

Retinopathy of Prematurity: A Global Perspective and Recent Developments

Cited by 54 publications

References 139 publications

Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease

Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease

A Multicenter Study of Retinopathy of Prematurity Follow-Up Adherence

Cesarean delivery was associated with low morbidity in very low birth weight infants: A retrospective cohort study

Contact Info

Product

Resources

About