Retinopathy in Tropical Pancreatic Diabetes

Mohan, Rema; Rajendran, Babu; Mohan, Viswanathan; Ramachandran, Ambady; Viswanathan, M; Kohner, Eva M.

doi:10.1001/archopht.1985.01050100063020

Cited by 36 publications

(9 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no association in the present study or in other studies between recent glycemic control and retinopathy or AER in either group (4,5,11,(14)(15)(16)(17). These findings contrast with the strong association between long-term glycemic control and the presence and severity of retinopathy and microalbuminuria in IDDM (8,14,15).…”

Section: Conclusion-mentioning

confidence: 41%

“…In those studies only early background retinopathy, glomerular hyperfiltration, and microalbuminuria were found. Our findings are in keeping with the observations by Mohan et al (11), who reported that 3 of their 40 patients (8%) with diabetes secondary to tropical pancreatitis had proliferative retinopathy. Additionally, in another report, 7% had overt nephropathy (urinary protein excretion >500 /u-g), and 17% renal insufficiency (serum creatinine >133 /xmol/1) (12).…”

Section: Conclusion-mentioning

confidence: 46%

See 1 more Smart Citation

The Prevalence and Severity of Microvascular Complications in Pancreatic Diabetes and IDDM

Levitt

Adams²,

Salmon³

et al. 1995

Diabetes Care

View full text Add to dashboard Cite

show abstract

Section: Conclusion-mentioning

confidence: 41%

Section: Conclusion-mentioning

confidence: 46%

The Prevalence and Severity of Microvascular Complications in Pancreatic Diabetes and IDDM

Levitt

Adams²,

Salmon³

et al. 1995

Diabetes Care

View full text Add to dashboard Cite

show abstract

“…However, studies from Chennai in the 1980s showed the presence of advanced stages of diabetic retinopathy in these patients [56]. Nephropathy, neuropathy [57] and autonomic neuropathy [58,59] have also been reported in these patients, with studies reporting onset of autonomic neuropathy as early as 2 years after the diagnosis [60].…”

Section: Complicationssupporting

confidence: 41%

Fibrocalculous pancreatic diabetes (FCPD)

Unnikrishnan

Mohan

2014

Acta Diabetol

View full text Add to dashboard Cite

Fibrocalculous pancreatic diabetes (FCPD) is an uncommon form of diabetes that occurs as a result of chronic calcific pancreatitis, in the absence of alcohol abuse. The disease is restricted to tropical regions of the world, and southern India has the highest known prevalence of FCPD. The typical patient with FCPD is a lean adolescent or young adult of either sex, presenting with history of recurrent bouts of abdominal pain and steatorrhea. Demonstration of large, discrete pancreatic calculi by plain radiographs or ultrasonography of the abdomen is diagnostic. While the exact etiology of FCPD is unknown, genetic, nutritional and inflammatory factors have been hypothesized to play a role. Diabetes in FCPD is often brittle and difficult to control; most patients require multiple doses of insulin for control of glycemia. However, in spite of high blood glucose levels, patients rarely develop ketosis. Malabsorption responds to pancreatic enzyme supplementation. Surgical removal of stones is indicated for symptomatic relief of intractable pain. While patients with FCPD develop microvascular complications as frequently as those with type 2 diabetes, macrovascular disease is uncommon. Development of pancreatic malignancy is the most dreaded complication and should be suspected in any patient who complains of weight loss, back pain or jaundice.

show abstract

“…diabetes began to attract attention, and the prevalence and characteristics of retinopathy have been studied in many cases of pancreatic diabetes (Maekawa et al 1978; Tiengo et al 1983; Couet et al 1985; Mohan et al 1985).…”

supporting

confidence: 42%

“…These findings supported the view proposed by Sprague (1947) and Deckert (1960). Regarding the severity of diabetic retinopathy, the prevalence of severe retinopathy (i.e., proliferative retinopathy) in patients with pancreatic diabetes has been reported to be low (Maekawa et al 1978;Mohan et al 1985). In the present study, however, rapid progression of retinopathy was observed even in patients in whom calcifying pancreatitis was detected earlier than diabetes.…”

Section: Discussionmentioning

confidence: 41%

Diabetic Retinopathy in Japanese Patients with Long-Standing Pancreatic Diabetes Due to Calcifying Pancreatitis.

Nakamura

Imamura

Takebe

et al. 1994

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

This study analyzed the prevalence, aggravating factors (including duration of diabetes, glycemic control, body mass index, hypertension, serum total cholesterol, changes of ST on ECG and diabetic therapies) and characteristics of diabetic retinopathy in 75 patients with pancreatic diabetes resulting from calcifying pancreatitis. The patients were divided into three Groups: Group I (27 patients in whom diabetes was detected earlier than pancreatic stones), Group II (36 patients in whom diabetes and pancreatic stones were simultaneously detected) and Group III (12 patients in whom pancreatic stones were detected earlier than diabetes). The prevalence of retinopathy was dependent on the duration of diabetes as well as poor glycemic control. It was significantly (p <0.01) higher among the patient with the duration of diabetes that was more than 5 years than that of the patients whose duration was less than 5 years. The prevalence of retinopathy in Group I (63%) was significantly (p <0.05) higher than that in Group 11 (30.6%) and Group III (12.5%). Proliferative retinopathy was not found in any patients with a duration of diabetes less than 5 years, while it was found in 5 patients with a duration of more than 5 years (5 cases out of 31 patients). Diabetic retinopathy was correlated with the duration of diabetes and glycemic control, and was not linked to frequency of hypoglycemia and family history of diabetes. From the results above, we concluded that diabetic retinopathy in patients with pancreatic diabetes due to calcifying pancreatitis might be taken as evidence that such complications are primarily due to chronic hyperglycemia and the duration of diabetes mellitus rather than to genetic factors and other factors (body mass index, hypertension, serum total cholesterol and diabetic therapies). diabetic retinopathy; pancreatic diabetes; duration of diabetes; chronic hyperglycemia; calcifying pancreatitisIn the past, the prevalence of complication by diabetic retinopathy in patients with pancreatic diabetes was thought to be low (Sevel et al. 1971). However, after Sprague reported the complication of pancreatic diabetes (microangiopathy) in 1947 (Sprague 1947), microangiopathy in patients with pancreatic

show abstract

Retinopathy in Tropical Pancreatic Diabetes

Cited by 36 publications

References 18 publications

The Prevalence and Severity of Microvascular Complications in Pancreatic Diabetes and IDDM

The Prevalence and Severity of Microvascular Complications in Pancreatic Diabetes and IDDM

Fibrocalculous pancreatic diabetes (FCPD)

Diabetic Retinopathy in Japanese Patients with Long-Standing Pancreatic Diabetes Due to Calcifying Pancreatitis.

Contact Info

Product

Resources

About