Retinopathy in patients with sickle cell trait

Reynolds, Sherrol; Besada, Eulogio; Winter-Corella, Christine

doi:10.1016/j.optm.2007.04.100

Cited by 25 publications

(25 citation statements)

References 28 publications

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“…The retinopathy is an uncommon complication in individuals with sickle cell trait except for the cases of sickle cell trait associated with systemic arterial hypertension, diabetes mellitus, syphilis, tuberculosis and sarcoidosis [8–10]. But occurring more frequently in patients with the most clinically significant haemoglobinopathies: the SC, the S-thalassemia and the SS and after 20 year-old [9, 10]. The retinopathy is due to the vaso-occlusive processes.…”

Section: Discussionmentioning

confidence: 99%

“…Sickling cells are red blood cells with abnormal shape and lower deformability which can cause them to undergo haemolysis (haemolytic anaemia) [1]. The haemolytic anaemia and the vaso-occlusive processes lead to retinal hypoxia, ischemia, infarction and neovascularization [9, 11]. This is due to their or be removed by macrophages in the spleen.…”

Section: Discussionmentioning

confidence: 99%

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A retinopathy in young patient with co-inheritance of heterozygous alpha + −thalassemia and sickle trait: a case report

Ouzzif¹,

Maataoui

Traore³

et al. 2017

BMC Ophthalmol

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BackgroundThe retinopathy is an uncommon complication in individuals with sickle cell trait except for the cases of sickle cell trait associated with systemic arterial hypertension, diabetes mellitus, syphilis, tuberculosis and sarcoidosis.Case PresentationA retinopathy in a 16 year-old child with no history of consanguinity in the parents revealed a sickle S trait associated to heterozygous alpha thalassemia. His mother has Sickle cell anaemia (Hb SS) and his father is a carrier of heterozygous alpha-thalassemia status that it was unknown before.ConclusionThis case report describes a proliferative retinopathy in a 16 year-old patient with co-inheritance of heterozygous alpha + −thalassemia and sickle trait.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A retinopathy in young patient with co-inheritance of heterozygous alpha + −thalassemia and sickle trait: a case report

Ouzzif¹,

Maataoui

Traore³

et al. 2017

BMC Ophthalmol

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“…15 The most frequently reported complications in SCT patients are kidney or eye failure. [5][6][7]16,17 Renal disease is dominated by papillary necrosis manifested clinically by hematuria. 5,6,12,16 Symptoms were dominated by osteoarticular pain.…”

Section: Discussionmentioning

confidence: 99%

Morbidity associated with sickle cell trait carriers

et al. 2016

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Background: Sickle cell trait carriers has long considered asymptomatic. This affirmation is now challenged because many patients complain of osteoarticular pain and several organic degenerative complications in particular; renal, eye and sudden death have been described. The objective of this study was to evaluate the morbidity of sickle cell trait and identify risk factors associated.Methods: This is a prospective study with duration of 16 months including 50 patients with sickle cell trait received regular visits (every 6 months) for painful events. Biological assessment was carried out systematically to eliminate rheumatic disease (CRP, ASLO, latex Waler Rose) or metabolic disorders (serum calcium, serum magnesium, and serum uric acid). A correlation between clinical and laboratory data was performed to study the relationship between morbidity observed and biological abnormalities.Results: Mean age of patients was 32 years (12-59) and mean age at diagnosis was 24 years (12-55 years). Sex ratio M/F was 0.16. Clinical symptoms were osteoarticular pain (88%), headache (86%), abdominal pain (76%), muscle cramps (70%), dizziness (56%), biliary lithiasis (6%), femoral head osteonecrosis (2%) and gross haematuria (2%). Seventeen patients (34%) had abnormal metabolic or rheumatic analysis. No risk factor associated with morbidity of patients was identified.Conclusions: This work has allowed us to find that the symptoms presented by sickle cell trait patients are dominated by painful events. This morbidity associated with porting sickle cell trait was not secondary to inflammatory or metabolic disorders or physical activity.

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“…4 We theorize that the increased blood viscosity (due to Hb AC), and the narrowed vessels (due to hypertension), acted synergistically to cause occlusive microangiopathy, which lead to proliferative neovascularization. Our case demonstrates how two non-neovasculogenic diseases, if coexisting, can cause sight-threatening retinopathy.…”

Section: Commentmentioning

confidence: 99%

“…2-4 Many reports have described RNFL morphological changes after ILM peeling during vitrectomy with TD OCT. [1][2][3][4] Removal of the ILM is a common procedure in macular hole surgery, as it increases the probability that the macular hole will close. In our case, we used SD OCT, which provides images of greater clarity and higher resolution than afforded by TD OCT. SD OCT clearly revealed the dimple margins and the exact depth of each DONFL.…”

Section: Conflict Of Interestmentioning

confidence: 99%