Retinopathy and Dyslipidemia in Type II Diabetes Mellitus in Egyptian Patients

El-Mofty, Hala Mohamed; Hakim, Mohamad A. Abdel; Din, Hala Ali Gamal El; Allah, Ossama Khalaf; Mosaad, Pierre Samir

doi:10.4172/2155-9570.1000265

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Our findings concerning duration, sex, smoking, and blood pressure agreed with several studies such as, Al Aldebasi et al [21] and El Mofty et al [22] studies that documented a statistically significant relationship between DR and dyslipidemia and all these variables. had DME (Table 4).…”

Section: Sci Forschensupporting

confidence: 92%

Association between Dyslipidemia and Diabetic Retinopathy in Type 2 Diabetic Patients

Elagamy¹,

Br²,

Zaaidi³

2019

J Ophthalmic Stud

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This study was conducted to assess the association between dyslipidaemia, blood pressure and diabetic retinopathy (DR) in type 2 diabetic patients. In addition, evaluation of the association between dyslipidemia and diabetic macular edema (DME) was performed. Design:This study was a retrospective and cross-sectional design, observational, and quantitative study. Subjects and Methods:This study included 800 patients with type 2 DM (386 males and 414 females). The age range was between 35-55 years. They were divided into two groups: 400 patients have DR (group 1), and 400 patients have not been previously diagnosed with DR (group 2). History and medical records of each diabetic patient were reviewed. Also, ophthalmological records of all subjects were reviewed including visual acuity and Intra Ocular Pressure (IOP) measurement using Air puff tonometer, macular thickness measured by Fourier-Domain Optical Coherence Tomography (OCT) and retinal imaging performed using Optomap 200° Ultra-Widefield (UWF) Digital retinal scan. Measurements of blood pressure for all patients were reviewed. The last blood samples were reviewed for all subjects between 6 months to 1 year prior to our ophthalmic examination. Serum total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low lipoprotein density-cholesterol (LDL-C), triglycerides (TG), plasma glucose and glycated hemoglobin (HbA1c) were taken. In addition, body mass index (BMI) and 10-year risk of Atherosclerotic Cardiovascular Disease (ASCVD) were calculated.Results: There was a statistically significant relationship between DM duration and DR (P<0.0001). Group 1 showed a statistically significant higher systolic and diastolic blood pressure than group 2 (P<0.0001) & (P=0.0289) respectively. Also, group 1 documented a statistically significant higher levels of TC, LDL-C and low levels of HDL-C (0.0013*, < 0.0001* and 0.0027*) respectively. But no statistically significant difference was detected between the 2 groups relating to TG (P=0.5478). Besides, patients with DME had a statistically significant high LDL-C and low HDL-C levels than patients without DME (P<0.002) and (P<0.003) respectively. Conclusion:This study documented significant association between DR and dyslipidemia in type 2 diabetic patients. In addition, the study confirmed that patients with DME had significant high LDL-C level and low HDL-C level than patients without DME. Moreover, the current study demonstrated significant association between DR and hypertension. Therefore, efficient control of hyperglycemia, dyslipidemia and hypertension would be of great value in delaying the progression of DR in these patients.

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Section: Sci Forschensupporting

confidence: 92%

Association between Dyslipidemia and Diabetic Retinopathy in Type 2 Diabetic Patients

Elagamy¹,

Br²,

Zaaidi³

2019

J Ophthalmic Stud

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“…Slightly higher prevalence of DR was seen in study done by Hala El-Mofty et al (55.36%). 7 In present study, all patients with DR had dyslipidaemia. We found statistically significant association of DR with high TC and high LDL-C with p value <0.001.…”

Section: Discussionsupporting

confidence: 47%

Study of Association of Diabetic Retinopathy With Dyslipidaemia in Type 2 Diabetes Mellitus Patients

Kolhar¹,

Priyanka²

2017

jebmh

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BACKGROUND Dyslipidaemia is highly prevalent in type 2 diabetes mellitus patients. The role of dyslipidaemia in macrovascular complications of diabetes have been extensively studied, but its role in microvascular complications namely retinopathy are still unclear. The present study was undertaken to study the association of diabetic retinopathy with diabetic dyslipidaemia. The aim of the study is to study the association between serum lipid profile and retinopathy in patients with type 2 diabetes mellitus. MATERIALS AND METHODS 100 patients with type 2 DM attending OPD or admitted over a period of 1 year were studied. Detailed history was taken and clinical examination was done. Serum lipid profile was studied in all patients and its association with diabetic retinopathy was assessed. RESULTS The prevalence of dyslipidaemia in DM patients in our study was 90%. There was significant association of diabetic retinopathy with high total cholesterol and Low-Density Lipoprotein-Cholesterol (LDL-C). However, diabetic retinopathy was not associated with triglycerides and High-Density Lipoprotein (HDL-C). CONCLUSION Dyslipidaemia is a common problem in patients with diabetes and it has significant association with diabetic retinopathy. Hence, patients should be managed with lifestyle modifications with or without lipid lowering agents to achieve target lipid values along with adequate glycaemic control to prevent or delay the appearance and progression of diabetic retinopathy.

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Association between serum apolipoprotein B and diabetic retinopathy in type 2 diabetic patients

Yousef

Hammad

Abdelrahman

et al. 2021

The Scientific Journal of Al-Azhar Medical Faculty, Girls

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Background Diabetic retinopathy (DR) is a major microvascular complication of diabetes. Aim of the work To study the association between serum apolipoprotein B (Apo-B) and DR in type 2 diabetes. Patients and methods This comparative study was conducted on 75 patients with type 2 diabetes recruited from the Endocrinology and Ophthalmology Departments of Al-Zahraa University Hospital. They were divided into three groups according to DR grading: group A included 31 patients without DR, group B included 27 patients with nonproliferative DR, and group C included 17 patients with proliferative DR. Detailed history, clinical examination, and anthropometric measurements were assessed for all selected patients. Fasting and 2-h postprandial blood glucose levels, glycosylated hemoglobin, total cholesterol (CHO), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and Apo-B were measured. Fundus examination was done for all participants. Results CHO, TGs, LDL-C, and Apo-B were statistically significantly higher in group C followed by group B and then group A. However, HDL-C was statistically significantly lower in group C followed by group B and then group A. A significant positive correlation was found between DR on one hand and age, diabetes duration, systolic blood pressure, diastolic blood pressure, glycosylated hemoglobin, CHO, TGs, LDL-C, and Apo-B on the other hand. DR correlated negatively with HDL-C. Conclusion Serum Apo-B levels may be a strong biomarker for DR than traditional lipids.

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Retinopathy and Dyslipidemia in Type II Diabetes Mellitus in Egyptian Patients

Cited by 3 publications

References 13 publications

Association between Dyslipidemia and Diabetic Retinopathy in Type 2 Diabetic Patients

Association between Dyslipidemia and Diabetic Retinopathy in Type 2 Diabetic Patients

Study of Association of Diabetic Retinopathy With Dyslipidaemia in Type 2 Diabetes Mellitus Patients

Association between serum apolipoprotein B and diabetic retinopathy in type 2 diabetic patients

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