This study was conducted to assess the association between dyslipidaemia, blood pressure and diabetic retinopathy (DR) in type 2 diabetic patients. In addition, evaluation of the association between dyslipidemia and diabetic macular edema (DME) was performed. Design:This study was a retrospective and cross-sectional design, observational, and quantitative study. Subjects and Methods:This study included 800 patients with type 2 DM (386 males and 414 females). The age range was between 35-55 years. They were divided into two groups: 400 patients have DR (group 1), and 400 patients have not been previously diagnosed with DR (group 2). History and medical records of each diabetic patient were reviewed. Also, ophthalmological records of all subjects were reviewed including visual acuity and Intra Ocular Pressure (IOP) measurement using Air puff tonometer, macular thickness measured by Fourier-Domain Optical Coherence Tomography (OCT) and retinal imaging performed using Optomap 200° Ultra-Widefield (UWF) Digital retinal scan. Measurements of blood pressure for all patients were reviewed. The last blood samples were reviewed for all subjects between 6 months to 1 year prior to our ophthalmic examination. Serum total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low lipoprotein density-cholesterol (LDL-C), triglycerides (TG), plasma glucose and glycated hemoglobin (HbA1c) were taken. In addition, body mass index (BMI) and 10-year risk of Atherosclerotic Cardiovascular Disease (ASCVD) were calculated.Results: There was a statistically significant relationship between DM duration and DR (P<0.0001). Group 1 showed a statistically significant higher systolic and diastolic blood pressure than group 2 (P<0.0001) & (P=0.0289) respectively. Also, group 1 documented a statistically significant higher levels of TC, LDL-C and low levels of HDL-C (0.0013*, < 0.0001* and 0.0027*) respectively. But no statistically significant difference was detected between the 2 groups relating to TG (P=0.5478). Besides, patients with DME had a statistically significant high LDL-C and low HDL-C levels than patients without DME (P<0.002) and (P<0.003) respectively. Conclusion:This study documented significant association between DR and dyslipidemia in type 2 diabetic patients. In addition, the study confirmed that patients with DME had significant high LDL-C level and low HDL-C level than patients without DME. Moreover, the current study demonstrated significant association between DR and hypertension. Therefore, efficient control of hyperglycemia, dyslipidemia and hypertension would be of great value in delaying the progression of DR in these patients.