Retinol dehydrogenase 10 reduction mediated retinol metabolism disorder promotes diabetic cardiomyopathy in male mice

Wu, Yandi; Huang, Tongsheng; Li, Xinghui; Shen, Conghui; Ren, Honglin; Wang, Haiping; Wu, Teng; Fu, Xinlu; Deng, Shijie; Feng, Zi-qi; Xiong, Shi-jie; Li, Hui; Gao, Saifei; Yang, Zhenyu; Gao, Fei; Dong, Lele; Cheng, Jianding; Cai, Weibin

doi:10.1038/s41467-023-36837-x

Cited by 15 publications

(6 citation statements)

References 43 publications

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“…For studies on the risk of diabetic complications from retinol, Zhang C et al showed that a higher dietary intake of retinol or retinol equivalents was associated with a lower risk of diabetic retinopathy, per 100 μg/day higher in dietary retinol equivalent intake was associated with 12% lower risk of diabetic retinopathy 17 . Retinol dehydrogenase-10 reduction-mediated disruption of retinol metabolism was found to promote diabetic myocardial ferroptosis in male mice, but this occurrence was ameliorated by retinol supplementation 18 .…”

Section: Discussionmentioning

confidence: 99%

“…A negative association was observed between higher dietary retinol or retinol equivalent intake and the risk of diabetic retinopathy, with each 100 μg/d increase in dietary retinol equivalent associated with a 12% reduction in risk 17 . Retinol metabolism disorder was involved in the development of myocardial injury in T2DM and the injury was improved with retinol intake 18 .…”

Section: Introductionmentioning

confidence: 99%

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Retinol intake is associated with the risk of chronic kidney disease in individuals with type 2 diabetes mellitus: results from NHANES

Ma¹,

Xie

Wang

et al. 2023

Sci Rep

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The aim of this study was to investigate the potential association between retinol intake and the risk of chronic kidney disease (CKD) in individuals with type 2 diabetes mellitus (T2DM). The study included individuals diagnosed with T2DM between 2009 and 2018 from the NHANES database. Demographic and laboratory test data were collected for these individuals, as well as information on CKD diagnosis. Logistic regression models were utilized to estimate the relationship between different retinol intakes and the risk of CKD in patients with T2DM. A total of 3988 patients were included in the study. The mean prevalence of CKD in the T2DM population in the United States from 2009 to 2018 was 36.98 (0.02)%. Multivariate logistic regression analysis revealed a 26% decrease in the incidence of CKD in individuals with higher retinol intake compared to those with lower retinol intake in T2DM (OR = 0.74; 95% CI 0.56–0.98). Furthermore, an increase in retinol intake per 1-standard deviation (SD) was associated with a 16% decreased risk of the incidence of CKD (OR = 0.84; 95% CI 0.72–0.97). Lower retinol intake is an independent risk factor for the onset of CKD in patients with T2DM, and augmenting moderate quantities of retinol confers potential nephroprotective advantages.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Retinol intake is associated with the risk of chronic kidney disease in individuals with type 2 diabetes mellitus: results from NHANES

Ma¹,

Xie

Wang

et al. 2023

Sci Rep

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“…Similar protective medicines, such as retinoic acid, may regulate ferroptosis to reduce damage to the ICM. However, their pharmacological mechanisms have not yet been explored ( 66 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring the molecular biology of ischemic cardiomyopathy based on ferroptosis‑related genes

Zhao,

Qiu,

Zeng

et al. 2024

Exp Ther Med

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Ischemic cardiomyopathy (ICM) is a serious cardiac disease with a very high mortality rate worldwide, which causes myocardial ischemia and hypoxia as the main damage. Further understanding of the underlying pathological processes of cardiomyocyte injury is key to the development of cardioprotective strategies. Ferroptosis is an iron-dependent form of regulated cell death characterized by the accumulation of lipid hydroperoxides to lethal levels, resulting in oxidative damage to the cell membrane. The current understanding of the role and regulation of ferroptosis in ICM is still limited, especially in the absence of evidence from large-scale transcriptomic data. Through comprehensive bioinformatics analysis of human ICM transcriptome data obtained from the Gene Expression Omnibus database, the present study identified differentially expressed ferroptosis-related genes (DEFRGs) in ICM. Subsequently, their potential biological mechanisms and cross-talk were analyzed, and hub genes were identified by constructing protein-protein interaction networks. Ferroptosis features such as reactive oxygen species generation, changes in ferroptosis marker proteins, iron ion aggregation and lipid oxidation, were identified in the H9c2 anoxic reoxygenation injury model. Finally, the diagnostic ability of Gap junction alpha-1 (GJA1), Solute carrier family 40 member 1 (SLC40A1), Alpha-synuclein (SNCA) were identified through receiver operating characteristic curves and the expression of DEFRGs was verified in an in vitro model. Furthermore, potential drugs (retinoic acid) that could regulate ICM ferroptosis were predicted based on key DEFRGs. The present article presents new insights into the role of ferroptosis in ICM, investigating the regulatory role of ferroptosis in the pathological process of ICM and advocating for ferroptosis as a potential novel therapeutic target for ICM based on evidence from the ICM transcriptome.

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“…Retinol dehydrogenase 10 (RDH10) metabolism disorder exists in the hearts of mice and the patients with type 2 diabetes mellitus (T2DM) ( 96 ). Reduction in RDH10 inhibits GPX4 and FSP1, promoting ferroptosis ( 97 ). In the model of T2D mice with DCM, sulforaphane (a Nrf2 activator) ameliorates cardiac ferroptosis in AMPK/Nrf2-dependent way ( 98 ).…”

Section: Ferroptosis and Cvdsmentioning

confidence: 99%

Current progress of ferroptosis in cardiovascular diseases

Zhang,

Guo

2023

Front. Cardiovasc. Med.

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Ferroptosis, a newly recognized form of nonapoptotic regulated cell death, is characterized by iron-dependent lipid peroxidation. Biological processes, such as iron metabolism, lipid peroxidation, and amino acid metabolism, are involved in the process of ferroptosis. However, the related molecular mechanism of ferroptosis has not yet been completely clarified, and specific and sensitive biomarkers for ferroptosis need to be explored. Recently, studies have revealed that ferroptosis probably causes or exacerbates the progress of cardiovascular diseases, and could be the potential therapeutic target for cardiovascular diseases. In this review, we summarize the molecular mechanisms regulating ferroptosis, inducers or inhibitors of ferroptosis, and the current progresses of ferroptosis in cardiovascular diseases. Furthermore, we discuss the emerging challenges and future perspectives, which may provide novel insights into the treatment of cardiovascular diseases.

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Retinol dehydrogenase 10 reduction mediated retinol metabolism disorder promotes diabetic cardiomyopathy in male mice

Cited by 15 publications

References 43 publications

Retinol intake is associated with the risk of chronic kidney disease in individuals with type 2 diabetes mellitus: results from NHANES

Retinol intake is associated with the risk of chronic kidney disease in individuals with type 2 diabetes mellitus: results from NHANES

Exploring the molecular biology of ischemic cardiomyopathy based on ferroptosis‑related genes

Current progress of ferroptosis in cardiovascular diseases

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