Exploring the molecular biology of ischemic cardiomyopathy based on ferroptosis‑related genes
Shi-Tao Zhao,
Zhi-Cong Qiu,
Rui-Yuan Zeng
et al.
Abstract:Ischemic cardiomyopathy (ICM) is a serious cardiac disease with a very high mortality rate worldwide, which causes myocardial ischemia and hypoxia as the main damage. Further understanding of the underlying pathological processes of cardiomyocyte injury is key to the development of cardioprotective strategies. Ferroptosis is an iron-dependent form of regulated cell death characterized by the accumulation of lipid hydroperoxides to lethal levels, resulting in oxidative damage to the cell membrane. The current u… Show more
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