Retinoids and Retinol Differentially Regulate Steroid Biosynthesis in Ovarian Theca Cells Isolated from Normal Cycling Women and Women with Polycystic Ovary Syndrome

Wickenheisser, Jessica K.; Nelson-DeGrave, Velen L.; Hendricks, Karen L.; Legro, Richard S.; Strauss, Jerome F.; McAllister, Jan M.

doi:10.1210/jc.2005-0330

Cited by 71 publications

(59 citation statements)

References 42 publications

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“…For this reason, increased levels of atRA are also associated with arresting follicle growth [10]. In another study, it was reported that differential responses to retinol and retinoids in normal and PCOS theca suggest that altered retinoic acid synthesis and action may be involved in augmented CYP17 gene expression and androgen production in PCOS [11]. Therefore we investigated whether vitamin A (retinol) levels are related to PCOS.…”

Section: Discussionmentioning

confidence: 98%

Assessment of the relationship between serum vitamin (A, B12, C, D, folate) and zinc levels and polycystic ovary syndrome

Külhan¹,

Kulhan²,

Naykı³

et al. 2017

Arch Med Sci Civil Dis

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Introduction There is increasing evidence that vitamin D affects insulin and glucose metabolism, and a low vitamin D status is suspected to be a risk factor for impaired glucose tolerance, insulin resistance and so polycystic ovary syndrome (PCOS), but there is no evidence to suggest that there is a relationship between vitamin A, vitamin B12, vitamin C, folate, zinc (Zn) and PCOS in the literature. We aimed to investigate the levels of vitamins A, B12, C and D and zinc and the association between vitamins A, B12, C and D, folate and zinc level and hormonal-biochemical parameters in PCOS. Material and methods: We recruited 65 women with PCOS and 67 healthy individuals. Correlations between clinical and metabolic parameters and vitamins A, B12, C and D and zinc status were analyzed separately in patients and controls. Results: Women with PCOS showed a decreased serum level of vitamin A compared with the control group (p < 0.05), but they showed no differences in the levels of vitamin D, vitamin B12, vitamin C, folate or Zn (p > 0.05). Conclusions: Our study found no differences in the absolute levels of serum vitamins B12, C, D, folate or Zn between PCOS patients and matched controls, but the vitamin A level was lower in PCOS patients. Prevalence of vitamins A, B12, C and D and Zn insufficiency was equally common among both patients and controls.

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Section: Discussionmentioning

confidence: 98%

Assessment of the relationship between serum vitamin (A, B12, C, D, folate) and zinc levels and polycystic ovary syndrome

Külhan¹,

Kulhan²,

Naykı³

et al. 2017

Arch Med Sci Civil Dis

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show abstract

“…It is also noteworthy that retinoids, which include retinol and its derivatives, have been found to regulate androgen biosynthesis and steroidogenic enzyme expression in normal and PCOS theca cells (Wood et al 2004). Wickenheisser et al further demonstrated that retinol stimulated CYP17 mRNA accumulation and promoter function in PCOS but not normal theca cells in humans, which could contribute to the excessive thecaderived androgen production in PCOS patients (Wickenheisser et al 2005). It would thus be intriguing to measure the hepatic level of RBP4 that transports retinol from the liver to target tissues.…”

Section: Retinol Binding Protein-4mentioning

confidence: 99%

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen¹,

Jia²,

Qiao³

et al. 2013

Journal of Molecular Endocrinology

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

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“…Serum was assayed for hCGmediated ovarian theca cell steroid hormone release, including progesterone, and steroid hormones indicative of androgen biosynthetic enzyme activity (17α-hydroxyprogesterone (17αOHP), dehydroepiandrosterone (DHEA), androstenedione, and testosterone (44). Serum was also assayed for estradiol, at least partially reflecting ovarian granulosa cell aromatization of hCG-stimulated theca cell androgen release.…”

Section: Hcg Stimulation Testmentioning

confidence: 99%

Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeys

Zhou

Bruns

Bird

et al. 2007

Reproductive Toxicology

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PURPOSE OF THE STUDY-To determine whether pioglitazone will improve menstrual cyclicity in a fetal programming model for polycystic ovary syndrome.BASIC PROCEDURES-Eight prenatally androgenized (PA) and 5 control female rhesus monkeys of similar age, body weight and body mass index received an oral placebo daily for 6-7 months followed, after at least 90 days, by daily oral dosing with pioglitazone (3mg/kg) for an additional 6-7 months. Blood was sampled thrice weekly to monitor ovulatory function, and a variety of endocrine challenges were performed to quantify changes in ovarian, gonadotropin and glucoregulatory function. MOST IMPORTANT FINDINGS-Pioglitazone normalized menstrual cycles in 5 out of 8 (62%)PA females (pioglitazone responsive; Pio RESP ). Pioglitazone increased serum 17α-hydroxyprogesterone responses to an hCG injection in Pio RESP PA females, while diminishing serum progesterone, and increasing DHEA and estradiol responses to hCG in Pio RESP PA and all normal females.PRINCIPAL CONCLUSIONS-Insulin resistance plays a mechanistic role in maintaining anovulation in a majority of PA female monkeys.

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Retinoids and Retinol Differentially Regulate Steroid Biosynthesis in Ovarian Theca Cells Isolated from Normal Cycling Women and Women with Polycystic Ovary Syndrome

Abstract: Differential responses to retinol and retinoids in normal and PCOS theca suggest that altered retinoic acid synthesis and action may be involved in augmented CYP17 gene expression and androgen production in PCOS.

Cited by 71 publications

References 42 publications

Assessment of the relationship between serum vitamin (A, B<SUB>12</SUB>, C, D, folate) and zinc levels and polycystic ovary syndrome

Assessment of the relationship between serum vitamin (A, B<SUB>12</SUB>, C, D, folate) and zinc levels and polycystic ovary syndrome

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeys

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