Retinoic acid: Topical treatment of senile or actinic keratoses and basal cell carcinomas

Bollag, W.; F, Ott

doi:10.1007/bf01965758

Cited by 59 publications

(26 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In other respects, ATRA can exert anti-tumoral activities and has been used as a chemotherapeutic agent because of its strong antiproliferative activity against several types of cancer [17,[44][45][46].…”

Section: Discussionmentioning

confidence: 99%

CYP4A11 is repressed by retinoic acid in human liver cells

et al. 2006

View full text Add to dashboard Cite

CYP4A11, the major fatty acid x-hydroxylase in human liver is involved in the balance of lipids, but its role and regulation are both poorly understood. We studied the effects of retinoids on the regulation of CYP4A11 in the human hepatoma cell line HepaRG. Treatment of HepaRG cells with all-trans-retinoic acid resulted in a strong decrease in CYP4A11 gene expression and apoprotein content and, furthermore, was associated with a 50% decrease in the microsomal lauric acid hydroxylation activity. Such a strong suppression of CYP4A11 expression by retinoids could have a major impact on fatty acid metabolism in the liver.

show abstract

Section: Discussionmentioning

confidence: 99%

CYP4A11 is repressed by retinoic acid in human liver cells

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Similarly, dimethylbenzanthraceneinduced skin tumours in mice and rabbits were inhibited by retinoic acid (Bollag, 1972;Prutkin, 1973). This work has been extended to clinical studies, which have shown that premalignant and malignant skin lesions and urinary bladder papillomas partially or completely regress after treatment with retinoic acid (Bollag and Ott, 1970;Evard and Bollag, 1972).…”

mentioning

confidence: 95%

Reversal of methylcholanthrene-induced changes in mouse prostates in vitro by retinoic acid and its analogues

Lasnitzki¹

1976

Br J Cancer

View full text Add to dashboard Cite

Summary.-The influence of vitamin A-related compounds on hyperplasia and metaplasia induced by methylcholanthrene was studied in mouse prostate glands in organ culture.Methylcholanthrene was found to cause extensive hyperplasia and squamous metaplasia of the prostatic epithelium which persisted after withdrawal of the carcinogen.The retinoids included retinoic acid and 6 of its structural analogues synthesized in an attempt to enhance the anticarcinogenic action and reduce the toxicity of the parent compound. These were the cyclopentenyl analogue 7699, A2-retinoic acid, 13-cis-a-retinoic acid and 3 aromatic analogues.Administration of the compounds following the carcinogen reduced the extent and incidence of hyperplasia significantly and with the exception of one compound reversed the squamous metaplasia. Two of the aromatic analogues, one with a terminal ethylamide group (1430), and the other with a terminal ethylester group (9369), proved to be the most potent inhibitors, followed by compound 7699 and retinoic acid. A2-retinoic acid and 13-cis-a-retinoic acid showed the lowest activity.The inhibition of hyperplasia appeared to be mediated via a reduction of DNA synthesis. It seemed unrelated to either the biological growth-promoting activity of the compounds or their surface-active properties.It is tentatively suggested that vitamin A and its analogues may act as hormones.

show abstract

“…There are a number of studies which evaluated the effectiveness of topical retinoids in the prevention and treatment of NMSCs, primarily AK [91,92,93,94,95,96,97,98,99,100,101]. The advantage of using topical retinoids is systemic toxicity avoidance, although there may be local adverse effects such as erythema, scaling, burning, and irritation which vary with the drug concentration.…”

Section: Classical Therapy Of Nmscsmentioning

confidence: 99%

Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers

Fernandes

Santos²,

Kovačević³

et al. 2017

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most common malignant tumors in humans. BCCs do not proliferate rapidly and most of the times do not metastasize, while SCCs are more infiltrative, metastatic, and destructive. AKs are precursor lesions of cutaneous SCCs. The classical therapy of NMSCs makes use of photodynamic therapy associated with chemotherapeutics. With improved understanding of the pathological mechanisms of tumor initiation, progression, and differentiation, a case is made towards the use of targeted chemotherapy with the intent to reduce the cytotoxicity of classical treatments. The present review aims to describe the current state of the art on the knowledge of NMSC, including its risks factors, oncogenes, and skin carcinogenesis, discussing the classical therapy against new therapeutic options.

show abstract

Retinoic acid: Topical treatment of senile or actinic keratoses and basal cell carcinomas

Cited by 59 publications

References 31 publications

CYP4A11 is repressed by retinoic acid in human liver cells

CYP4A11 is repressed by retinoic acid in human liver cells

Reversal of methylcholanthrene-induced changes in mouse prostates in vitro by retinoic acid and its analogues

Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers

Contact Info

Product

Resources

About