Retinoic Acid Increases Aquaporin 3 Expression in Normal Human Skin

Bellemère, Gaëlle; Stetten, Otto Von; Oddos, Thierry

doi:10.1038/sj.jid.5701047

Cited by 54 publications

(45 citation statements)

References 28 publications

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“…3 and 4). This observation is consistent with our previous study (19) and other reports (32) showing that atRA has similar effects on AQP3. Our data further suggest that inhibition of ERK activation is involved in the effects of atRA against UV-or oxidative stress-induced AQP1 downregulation, which is also consistent with previous research using cultured skin keratinocytes (33).…”

Section: Discussionsupporting

confidence: 83%

MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells

Jiang

Cao²,

Lu³

et al. 2009

Int J Mol Med

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Abstract. Aquaporins (AQPs) are a family of 13 small (~30 kDa/monomer), hydrophobic, integral membrane proteins. AQPs are expressed in various epithelial and endothelial cells involved in fluid transport. Here, we demonstrated for the first time that AQP1 is expressed in cultured human retinal pigment epithelial (RPE) cells (ARPE-19 cell line). Ultraviolet radiation (UVB) and H 2 O 2 , two major factors causing RPE cell damage, induced AQP1 downregulation which was mediated by MEK/ERK activation. UV and H 2 O 2 as well as AQP1-specific siRNA knockdown impaired water permeability of ARPE-19 cells. Notably, pretreatment with all-trans retinoic acid attenuated UV-and H 2 O 2 -induced AQP1 downregulation and water permeability impairment. Considering that water permeability is involved in multiple functions of RPE cells such as cellular junction formation, fluid or protein exchange and barrier formation, our data elucidated a novel mechanism through which UV radiation and oxidative stress induce eye cell damage. Our results further support the notion that all-trans retinoic acid might be useful for protection against UV or oxidative stress-induced eye cell damage.

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Section: Discussionsupporting

confidence: 83%

MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells

Jiang

Cao²,

Lu³

et al. 2009

Int J Mol Med

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“…In accordance, in a research on mice, treatment with retinoic acid on systemic lupus erythematous prone NZB/WF1 mice decreased auto-immune nephritis and increased survival and, therefore, retinoic acid may represent a novel treatment approach for lupus nephritis (14). Furthermore, retinoic acid increases expression of aquaporin-3 (that is decreased in depigmented epidermis) in epidermal keratinocytes and decreases keratinocytes survival (15,16). Multiple studies showed that tretinoin also decreases thickness of horney layer and decreases number of cell layers and, therefore, increases the absorption of other topical drugs, like topical antibiotics (17,18).…”

Section: Discussionmentioning

confidence: 86%

Comparative Study of the Therapeutic Effects of Topical Mometasone Furoate 0.1% Plus Tretinoin 0.05% and Topical Mometasone Furoate 0.1% Plus Eucerin in the Treatment of Vitiligo

Behrangi

Rasi

Jannati³

et al. 2015

J Skin Stem Cell

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Background: Long-term treatments with topical corticosteroids, for diseases like vitiligo, are associated with the risk of skin atrophy. Objectives: Recent studies suggest that administration of topical tretinoin, with a corticosteroid, diminishes skin atrophy without impacting the steroid's anti-inflammatory effects. Patients and Methods: A placebo-controlled, paired-comparison, left-right study was conducted for a period of 6 months on topical tretinoin 0.05% and mometasone furoate 0.1 % with topical mometasone furoate 0.1% and eucerin in 16 patients, diagnosed with generalized vitiligo. Clinical responses and side effects were assessed after 3 and 6 months. Results: After 6 months treatment with topical mometasone furoate 0.1 % and tretinoin 0.05%, an excellent response was found in two (12.50%) patients, a moderate response in 13 (81.25%) and mild response in one (6.25%) patient. Two patients (12.5%) showed side effects. After 6 months treatment with topical mometasone furoate 0.1% and eucerin, an excellent response was observed in one (6.25%) patient, a moderate response in eight (50%), mild response in six (37.5 %), and no response in one (6.25%) of the patients. Eight (50%) patients had side effects. After 6 months treatment, the topical tretinoin 0.05% and mometasone furoate 0.1% had more efficacy than mometasone furoate 0.1% and eucerin (P = 0.02). Conclusions: Combination therapy with tretinoin plus topical corticosteroids is safe and effective and provides an alternative in the treatment of patients with vitiligo.

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“…Recently resveratrol, a natural polyphenol was found to downregulate AQP3 expression in human keratinocytes (Wu et al 2014). trans-Zeatin, retinoid, and Kanglaite have all been found to upregulate expression of AQP3 in the skin (Bellemère et al 2008;Ji et al 2010;Shan et al 2012). Alltrans retinoic acid, while inducing AQP3 expression by itself, attenuates UV-induced downregulation of AQP3 (Cao et al 2007).…”

Section: Discussionmentioning

confidence: 96%

EPA attenuates ultraviolet radiation-induced downregulation of aquaporin-3 in human keratinocytes

Jeon

Kang

Lee³

et al. 2014

Arch. Pharm. Res.

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Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid (ω-3 PUFA) that protects against photodamage and photocarcinogenesis in mammals. Aquaporin-3 (AQP3) is a water/glycerol transport protein that is found in basal layer keratinocytes. In this study, we have investigated the protective effect of EPA against ultraviolet B (UVB)-induced AQP3 downregulation in human keratinocytes. EPA treatment was found to increase AQP3 gene and protein expression in human epidermal keratinocytes (HaCaT). Using a specific inhibitor, we observed that the effect of EPA on AQP3 expression was mediated by extracellular signal-regulated kinase (ERK) activation. UVB radiation induced AQP3 downregulation in HaCaT cells, and it was found that EPA treatment attenuated UVB-induced AQP3 reduction and the associated cell death. UVB-induced downregulation of AQP3 was blocked by EPA and p38 inhibitor SB203580. Collectively, the present results show that EPA increased AQP3 expression and that this led to a reduction UVB-induced photodamage.

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Retinoic Acid Increases Aquaporin 3 Expression in Normal Human Skin

Cited by 54 publications

References 28 publications

MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells

MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells

Comparative Study of the Therapeutic Effects of Topical Mometasone Furoate 0.1% Plus Tretinoin 0.05% and Topical Mometasone Furoate 0.1% Plus Eucerin in the Treatment of Vitiligo

EPA attenuates ultraviolet radiation-induced downregulation of aquaporin-3 in human keratinocytes

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