Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression

Lee, Jeong Min; Jang, Young‐Saeng; Jin, Byoungho; Kim, Sun‐Jin; Kim, Hyeonjin; Kwon, Bo-Eun; Ko, Hyun‐Jeong; Yoon, Sung‐il; Lee, Geun‐Shik; Kim, Woan-Sub; Seo, Goo-Young; Kim, Pyeung-Hyeun

doi:10.1038/cmi.2015.73

Cited by 17 publications

(15 citation statements)

References 31 publications

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“…RA has several functions that contribute to a potent mucosal IgA response, including facilitating the proliferation and differentiation of immunocompetent cells (Pantazi et al, 2015;Rühl, 2007), amplifying the induction of IgA class switching and imprinting of the gut-homing receptors on T and B cells (Mora & von Andrian, 2009). In addition to CCR9 and its chemokine ligand CCL25 (Lee et al, 2016;Mora et al, 2006;Seo et al, 2014), numerous ligand-activated nuclear receptors, such as the retinoic acid receptor (RAR), retinoid X receptor (RXR), and peroxisome proliferator-activated receptor (PPAR) (Hoag, Nashold, Goverman, & Hayes, 2002;Iwata, Eshima, & Kagechika, 2003;Seo et al, 2014), are involved in the mucosal IgA response induced by RA. Supplementation of maternal mice with β-carotene during pregnancy increased the lactation of IgA antibody-secreting cells (ASC) in the mammary glands (Nishiyama et al, 2011).…”

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confidence: 99%

Effects of supplementation with β‐carotene on the growth performance and intestinal mucosal barriers in layer‐type cockerels

Hui

et al. 2020

Animal Science Journal

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Development of automatic breeding management accelerated the growth of chicks. However, health conditions of the chicks become more susceptible to external antigens. Mortality of neonates is closely related to the economic profit; thus, maintaining the fitness of young poult is the primary mission. The early growth and development of the intestine in the poults is a crucial process related to the fitness of the chicks. Gut barriers form a key line of defense against the foreign antigens of the environment and play the critical roles in maintenance of intestinal homeostasis. The primary layer of gut barriers includes an outer layer comprised of bacteria and an inner layer associated with high concentrations of sIgA and mucins (Chen, Tellez, Richards, & Escobar, 2015). Over the past few decades, the intestinal microbiota has been shown to play important roles in growth performance, immune status, and intestinal health in broiler chickens (Luan, Sun, Wang,

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confidence: 99%

Effects of supplementation with β‐carotene on the growth performance and intestinal mucosal barriers in layer‐type cockerels

Hui

et al. 2020

Animal Science Journal

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“…Retinoic acid promotes mucosal immunity by inducing the expression of mucosal homing receptors α4β7 and CCR9 on T and B lymphocytes (13, 19, 20). The effect of RA on B cells leads to the isotype switching of IgA antibodies (19, 36–39). This is in accordance with our findings, indeed higher OVA and H56 specific IgA and specific IgA secreting long living plasma cells were induced in mice after parenteral immunization with CAF01+H56 with RA, as compared to control mice.…”

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confidence: 99%

Parenteral Vaccination With a Tuberculosis Subunit Vaccine in Presence of Retinoic Acid Provides Early but Transient Protection to M. Tuberculosis Infection

et al. 2019

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Most microbes invading through mucosal surfaces cause disease and therefore strategies to induce mucosal immune responses are strongly needed. Vitamin A metabolites, such as retinoic acid (RA), play crucial roles in programming T and B cells to home to mucosal compartments, therefore we evaluated the capacity of RA to elicit mucosal immune responses against tuberculosis (TB) after parenteral vaccination. We found that mice immunized through subcutaneous injections with the TB subunit vaccine (CAF01+H56) in presence of RA show enhanced mucosal H56-specific IgA responses and enhanced Ag-specific CD4 + T lymphocytes homing to the lung as compared with control mice. Immunization with CAF01+H56 in presence of RA resulted in lower bacterial loads in the lungs of mice 14 days after challenge with virulent Mycobacterium tuberculosis (Mtb) as compared to mice immunized in the absence of RA or vaccinated with BCG. Higher amounts of IFNγ and IL-17 pro-inflammatory cytokines were found in lung homogenates of mice immunized with CAF01+H56 and RA 24 h after Mtb infection. However, 6 weeks after infection the protection was comparable in vaccinated mice with or without RA even though treatment with RA during immunization is able to better contain the inflammatory response by the host. Furthermore, at later stage of the infection a higher percentage of Mtb specific CD4 + PD1 + T lymphocytes were found in the lungs of mice immunized with CAF01+H56 and RA. These data show that an enhanced mucosal immune response is generated during parenteral vaccination in presence of RA. Furthermore, RA treatment contained the bacterial growth at an early stage of the infection and limited the inflammatory response in the lung at later time points.

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“…Considering the roles of mucosal and systemic IgA in COVID-19, inducing IgA production (using lactoferrin to activate canonical TGF-β signalling [13] or retinoic acid to enhance lactoferrin-induced IgA responses [14]) has been proposed as a novel therapy for severe COVID-19. However, as highlighted by our study, enhanced IgA responses observed in severe COVID-19 might confer damaging effects in severe COVID-19.…”

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Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

et al. 2020

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In comparison to severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2 appears to be more contagious [1], and coronavirus disease 2019 (COVID-19) patients demonstrate varied clinical manifestations distinct from those seen in patients with SARS-CoV and Middle East respiratory syndrome coronavirus infections [2]. Collective results from the clinical and epidemiological observations suggest a distinct viral-host interaction in COVID-19 patients. Profiling of the antibody response during SARS-CoV-2 infection may help improve our understanding of the viral-host interaction and the immunopathological mechanisms of the disease. Studies on humoral responses to infections have been mainly geared toward the production of high-affinity IgG antibodies that efficiently resolve an infection. It has been well recognised, however, that humoral immune response to infection can be a double-edged sword that either serves as a protective mechanism to resolve the infection or aggravates the tissue injury, e.g. the IgG response causes fatal acute lung injury by skewing the inflammation-resolving response in SARS-CoV [3]. In the case of respiratory infection, while IgM and IgG isotypes have been the primary emphasis in characterising immunity, mucosal and systemic IgA responses that may play a critical role in the disease pathogenesis have received much less attention. This study was designed to better understand the timing and patterns of humoral immune responses to SARS-CoV-2 in a cohort of COVID-19 patients and evaluate their relationship with the disease course and severity. 37 patients with COVID-19, with a mean±SD age of 52.3±16.3 years, were enrolled in this study. The enrolled COVID-19 patients consisted of 25 (67.6%) males and 12 (32.4%) females. All patients tested positive for viral nucleic acid of SARS-CoV-2 (Real-Time Fluorescent RT-PCR Kit; BGI, Shenzhen, China). According to the "Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection" published by the National Health Commission of China, the enrolled COVID-19 patients were categorised into two groups: 20 (54.1%) severe cases and 17 (46.0%) nonsevere cases [4]. The nonsevere group included patients with mild and moderate symptoms who were also required to be admitted to hospital by the COVID-19 control policy in China. The severe group included severe and critically ill patients. Mild patients did not demonstrate abnormal computed tomography (CT) imaging. Moderate patients had fever and/or classical respiratory symptoms, and typical CT images of viral pneumonia. Severe patients met at least one of following additional conditions: 1) shortness of breath with a respiratory rate ⩾30 times•min −1 ; 2) oxygen saturation measured by pulse oximetry (resting state) of ⩽93%; or 3) arterial oxygen tension/inspiratory oxygen tension of ⩽300 mmHg. Critically ill patients met at least one of the extra following conditions in addition to the COVID-19 diagnosis: 1) respiratory failure that required mechanical ventilation; 2) shock; or 3) mu...

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Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression

Cited by 17 publications

References 31 publications

Effects of supplementation with β‐carotene on the growth performance and intestinal mucosal barriers in layer‐type cockerels

Effects of supplementation with β‐carotene on the growth performance and intestinal mucosal barriers in layer‐type cockerels

Parenteral Vaccination With a Tuberculosis Subunit Vaccine in Presence of Retinoic Acid Provides Early but Transient Protection to M. Tuberculosis Infection

Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

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