Retinoblastoma in Turkey: Results From a Tertiary Care Center in Ankara

Abstract

The overall risk of enucleation was 75% in eyes with unilateral retinoblastoma and 24% in eyes with bilateral retinoblastoma. Extraocular retinoblastoma carries a 75% risk of systemic metastasis and 67% risk of death.

Primary intravenous chemotherapy for group D retinoblastoma: a 13-year retrospective analysis

“…This is not surprising, as per definition, D eye tumours hold common features, including tumour size and the presence of retinal detachment and seeding. To note, in two relatively large cohort studies on retinoblastoma eyes treated by primary IVC,20 29 group D eyes were analysed as part of a larger cohort containing additional ICRB groups and no subanalysis was performed. In the literature, there are no reports of specific risk factors for secondary enucleation of D eyes treated initially with IVC.…”

Risk definition and management strategies in retinoblastoma: current perspectives

“…High-risk retinoblastoma leads to metastasis in 24% of patients if not treated with systemic chemotherapy, compared with 4% of those who receive it 17. However, it is a significant contributor to retinoblastoma-related mortality in developing nations 22,23. Clinical, genetic, and histopathologic features have been already identified and appreciated as risk factors for metastatic disease 24.…”

Targeted retinoblastoma management

“…This approach involves The initial reports on IVC for retinoblastoma led the way to a new era for retinoblastoma management [5][6][7][8]. Since then, there have been numerous publications on the efficacy of IVC for retinoblastoma from around the world [28][29][30][31][32][33]. The indications for various chemotherapy protocols can vary in different retinoblastoma centers.…”