Retinoblastoma: A SEER Dataset Evaluation for Treatment Patterns, Survival, and Second Malignant Neoplasms

Tamboli, Diana A.; Topham, Allan; Singh, Nakul; Singh, Arun D.

doi:10.1016/j.ajo.2015.07.037

Cited by 33 publications

(28 citation statements)

References 18 publications

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“…1 The treatment of this entity has evolved significantly in the last 30 years. 2 Therapeutic paradigms have focused on minimizing the morbidity and mortality arising from metastasis, associated cerebral malignancy in cases of hereditary retinoblastoma (most commonly of the pineal gland and referred to as trilateral retinoblastoma), and secondary neoplasms, while maintaining visual function. Consequently there has been increased utilization of systemic 34 and targeted 5–8 chemotherapy, 25–8 with a corresponding shift away from radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently there has been increased utilization of systemic 34 and targeted 5–8 chemotherapy, 25–8 with a corresponding shift away from radiotherapy. 2 …”

Section: Introductionmentioning

confidence: 99%

“…10 Tamboli et al examined the effects of treatment modality on survival. 2 The specific longitudinal associations and disease patterns of this cancer have yet to be fully elucidated. The current study aims to evaluate the epidemiological trends in retinoblastoma over a 37-year interval via analysis of the Surveillance, Epidemiology, and End Results (SEER) Program tumor registry, specifically analyzing the impact of patient and tumor characteristics such as laterality, tumor stage, and tumor pathological grade.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological trends in 1452 cases of retinoblastoma from the Surveillance, Epidemiology, and End Results (SEER) registry

Andreoli

Chau

Shapiro

et al. 2017

Canadian Journal of Ophthalmology

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Purpose To assess retinoblastoma epidemiological trends in the Surveillance, Epidemiology, and End Results (SEER) registry. Methods All cases of retinoblastoma in the SEER database from 1973–2009 were identified. Kaplan-Meier survival analyses were performed for pathological grade, patient age, gender, year of diagnosis, and treatment modality. Cox proportional hazards regression assessed the impact of patient and tumor characteristics on survival. Findings 1,452 cases of retinoblastoma were analyzed. The mean patient age at diagnosis was 1.44 years. The tumor was unilateral in 71.0% or bilateral in 29.0%. The mean follow-up was 129.1 months. Overall survival increased during the study interval. Patients with bilateral tumors were diagnosed at an earlier age (0.46 years) than patients with unilateral disease (1.77 years; P < 0.0001). Bilateral retinoblastoma (90.3% 10-year overall survival) was associated with decreased overall survival than unilateral retinoblastoma (96.1% 10-year overall survival). Bilateral retinoblastoma was also associated with an increased incidence of non-ocular malignancies (7.8%) compared with unilateral retinoblastoma (1.3%; P < 0.0001). Grade 1 tumors were diagnosed at a younger age (0.94 years) than grade 3 (2.24 years) and grade 4 tumors (2.14 years; P < 0.0001). Lower grade and lower stage tumors were independently associated with increased survival. In multivariate Cox proportional hazards analysis, T stage and laterality were the only covariates that correlated with overall survival. Conclusions There appear to be associations between retinoblastoma tumor features such as tumor stage, pathological grade, and laterality with patient characteristics such as age at diagnosis, overall survival, and second malignancies.

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Section: Introductionmentioning

confidence: 99%

“…Consequently there has been increased utilization of systemic 34 and targeted 5–8 chemotherapy, 25–8 with a corresponding shift away from radiotherapy. 2 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epidemiological trends in 1452 cases of retinoblastoma from the Surveillance, Epidemiology, and End Results (SEER) registry

Andreoli

Chau

Shapiro

et al. 2017

Canadian Journal of Ophthalmology

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“…HER2 overexpression was negative in all RB cases (49 cases scored 0 and 11 scored 1+) and in the Y79 cell line. Conclusions: Overall, [6][7][8] . New treatment options are being developed to target specific RB genes and receptors, thus circumventing some of these potential safety issues [9,10] .…”

Section: Introductionmentioning

confidence: 90%

HER2 Overexpression in Retinoblastoma: A Potential Therapeutic Target

et al. 2017

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Background: Retinoblastoma (RB) is the most common primary intraocular malignancy. Current therapies are associated with high morbidity in the short- and long-term. Human epidermal growth factor receptor 2 (HER2) is a transmembrane protein detected in 15-30% of breast cancers, but it has also been described in other malignancies. Recently, it has been claimed that a truncated version of this protein is expressed in RB, responsive to directed therapies in vitro. We scored HER2 overexpression in RB tissue samples and discussed its potential clinical utility. Methods: HER2 overexpression was investigated using immunohistochemistry; the overexpression was evaluated with a score ranging from 0 to 3+ according to the membranous staining pattern in archival formalin-fixed, paraffin-embedded RBs. Results: A total of 60 RB cases and a RB cell line (Y79) were considered. The mean age at enucleation was 31.6 ± 31.5 months. The mean time from diagnosis to enucleation was 11.8 ± 11.2 months (range 1-44). Five (8%) cases were multifocal. HER2 overexpression was negative in all RB cases (49 cases scored 0 and 11 scored 1+) and in the Y79 cell line. Conclusions: Overall, we were not able to demonstrate the overexpression of HER2. Further studies should clarify and better elucidate the potential role of HER2-targeted therapies in RB.

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“…2 The standard treatment approach to advanced unilateral RB has traditionally been enucleation of the affected eye. 3 This approach results in cure in 99% of children. However, concomitantly, enucleation of an eye is associated with a significant negative long-term psychosocial impact.…”

Section: Introductionmentioning

confidence: 99%

The impact of monocular vision on motor function and quality of life in survivors of retinoblastoma

Weintraub

Reshef

Pe’er

et al. 2019

Pediatric Blood & Cancer

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Background Monocular vision has been found to have a negative effect on children's motion processing and motor functions. Yet, knowledge of motor function of survivors of retinoblastoma (RB) with monocular vision (due to enucleation, for example) is limited. This study examined motor function and its relationship to visual‐related and health‐related quality of life (HRQOL) in survivors of RB with monocular vision. Procedure Parents of 27 survivors of RB, who underwent an enucleation of one eye resulting in monocular vision, and of 21 typically developing children between the ages of 6 and 12, were administered questionnaires relating to their children's motor function (DCDQ), as well as vision‐related function (CVFQ) and HRQOL (PedsQL). Results Of the 27 survivors of RB, 7 (25.6%) were found to have difficulties in motor functions, compared with 1 (4.8%) child in the control group. The difficulties were faced mainly in daily function requiring control during movement, including jumping, running, and ball playing. Additionally, significant correlations were found between motor functions and children's QOL. Finally, survivors of RB with monocular vision were found to have lower QOL, specifically physical‐ and school‐related QOL. Conclusion Survivors of RB who have monocular vision have a higher rate of decreased motor function and lower QOL. These results point to a need for ongoing assessment of survivors of RB to allow timely detection of motor deficits and to institute appropriate therapeutic interventions.

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Retinoblastoma: A SEER Dataset Evaluation for Treatment Patterns, Survival, and Second Malignant Neoplasms

Cited by 33 publications

References 18 publications

Epidemiological trends in 1452 cases of retinoblastoma from the Surveillance, Epidemiology, and End Results (SEER) registry

Epidemiological trends in 1452 cases of retinoblastoma from the Surveillance, Epidemiology, and End Results (SEER) registry

HER2 Overexpression in Retinoblastoma: A Potential Therapeutic Target

The impact of monocular vision on motor function and quality of life in survivors of retinoblastoma

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