Retinal vessel oxygen saturation and vessel diameter in high myopia

Zheng, Qishan; Zong, Yao; Li, Li; Huang, Xia; Li, Lin; Yang, Wei; Yuan, Yongguang; Li, Yujie; He, Huining; Gao, Qianying

doi:10.1111/opo.12223

Cited by 36 publications

(52 citation statements)

References 37 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have investigated the oxygen saturation of retinal vessels in patients with diabetes, glaucoma or RP, indicating that changes in retinal oxygen saturation and vessel diameter are associated with underlying microvascular dysfunction and preclinical structural changes in ocular (Tiedeman et al 1998;Michelson & Scibor 2006;Ramm et al 2014;Yao et al 2016). In high myopia eyes, Gao et al reported a lower oxygen saturation and narrowing diameter in retinal arterioles (Zheng et al 2015). This is consistent with the data obtained in the present study, demonstrating an unusual anatomy and physiology of the retina in high myopia eyes, and rising the concerns about any microcirculation abnormality inherent to ICL implantation surgery.…”

Section: Discussionsupporting

confidence: 92%

“…; Zheng et al. ). This observation implied the ultrastructure changes of retina microcirculation in high myopia patients.…”

Section: Resultsmentioning

confidence: 98%

“…reported a lower oxygen saturation and narrowing diameter in retinal arterioles (Zheng et al. ). This is consistent with the data obtained in the present study, demonstrating an unusual anatomy and physiology of the retina in high myopia eyes, and rising the concerns about any microcirculation abnormality inherent to ICL implantation surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, pigmentary changes in the fundus high myopia patients and their different circumstances and heredity backgrounds may also influence the outcome of measurements, causing relative large standard variation (Jonas & Xu ; Zheng et al. ; Heitmar & Attardo ). Besides, in some highly myopia patients, the same retinal vessels were not selected presurgery, 1‐week postsurgery and 1‐month postsurgery (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Haemodynamics study showed that average retinal blood flow in high myopic eyes, with no serious retinopathy, was significantly decreased compared with emmetropic eyes (Shimada et al 2004). Recently, in Gao's study, decreased retinal oxygen saturation and decreased AV difference as well as narrowing retinal vessel diameter were observed in high myopic eyes, compared with normal subjects (Zheng et al 2015). The variations in retinal oxygen saturation might reflect early microangiopathy, which has been suggested to be correlated with unusual anatomy and physiology changes of the retina, not only in ocular diseases but also in ophthalmic surgery (S ın et al 2014;Lou et al 2015).…”

Section: Introductionmentioning

confidence: 96%

See 4 more Smart Citations

Assessing oxygen saturation in retinal vessels in high myopia patients pre‐ and post‐implantable collamer lens implantation surgery

Chen

Cai

et al. 2017

Acta Ophthalmologica

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 92%

“…; Zheng et al. ). This observation implied the ultrastructure changes of retina microcirculation in high myopia patients.…”

Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

See 3 more Smart Citations

Assessing oxygen saturation in retinal vessels in high myopia patients pre‐ and post‐implantable collamer lens implantation surgery

Chen

Cai

et al. 2017

Acta Ophthalmologica

Self Cite

View full text Add to dashboard Cite

show abstract

The retinal vasculature pathophysiological changes in vision recovery after treatment for indirect traumatic optic neuropathy patients

Gao

et al. 2021

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Purpose To evaluate the retinal vasculature pathophysiological changes of indirect traumatic optic neuropathy (ITON) patients after effective surgery. Methods Monocular ITON patients who underwent endoscopic trans-ethmosphenoid optic canal decompression (ETOCD) or conservative treatments in Zhongshan Ophthalmic Center from January 2017 to June 2020 were recruited. Visual acuity (VA), visual evoked potential (VEP), oxygen saturation of retinal blood vessels (SO2), and optical coherence tomography angiography (OCT-A) were measured. All patients were followed up at least 3 months after treatments. Results A total of 95 ITON patients were recruited, including 77 patients who underwent ETOCD and 18 patients who underwent conservative treatments. After treatments, more patients received ETOCD (59/77 = 76.6%) presented with improved VA compared with the patients with conservative treatments (6/18 = 33.3%). Compared with the pre-therapeutic measurements, VEP were significantly improved after surgery in ETOCD-treated patients (P < 0.05). Latent periods of P1 and N2, as well as amplitude of P2 of VEP parameters, showed more sensitive to vision recovery (P < 0.05). Retinal artery SO2 and the differences between arteries and veins were improved in ETOCD-treated patients (P < 0.05). Meanwhile, with OCT-A examination, the retinal thickness and retinal vessel density were notably better in ETOCD-treated patients after surgery than that in patients received conservative treatments (P < 0.05). Conclusions Vision recovery after effective treatment of ITON patients was associated with the increased oxygen saturation of retinal vessels, better availability of oxygen in the retina, greater vessel density, and thicker retinas, which might further underlie the vasculature mechanism of vision recovery in ITON patients.

show abstract

Imposed positive defocus changes choroidal blood flow in young human subjects

Świątczak

Schaeffel

Calzetti

2022

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Purpose It has previously been found that imposing positive defocus changes axial length and choroidal thickness after only 30 min. In the present study, we investigated whether these changes may result from an altered choroidal blood flow. Methods Eighteen young adult subjects watched a movie from a large screen (65 in.) in a dark room at 2 m distance. A 15-min wash-out period was followed by 30 min of watching the movie with a monocular positive defocus (+ 2.5D). Changes in axial length and ocular blood flow were measured before and after the defocus, by using low-coherent interferometer (LS 900, Haag-Streit, Switzerland) and a laser speckle flowgraphy (LSFG) RetFlow unit (Nidek Co., LTD, Japan), respectively. Three regions were analyzed: (1) the macular area, where choroidal blood flow can be measured, (2) the optic nerve head (ONH), and (3) retinal vessel segments. Results Changes in choroidal blood flow were significantly and negatively correlated with changes in axial length that followed positive defocus in exposed eyes (R = − 0.67, p < 0.01). The absolute values of changes in choroidal blood flow in the defocused eyes were significantly larger than in the fellow control eyes (2.35 ± 2.16 AU vs. 1.37 ± 1.44 AU, respectively, p < 0.05). ONH and retinal blood flow were not associated with the induced changes in axial length. Conclusions Positive defocus selectively alters choroidal, but not retinal or ONH blood flow in young human subjects after short-term visual exposure. The results suggest that blood flow modulation is involved in the mechanism of choroidal responses to optical defocus.

show abstract

Retinal vessel oxygen saturation and vessel diameter in high myopia

Cited by 36 publications

References 37 publications

Assessing oxygen saturation in retinal vessels in high myopia patients pre‐ and post‐implantable collamer lens implantation surgery

Assessing oxygen saturation in retinal vessels in high myopia patients pre‐ and post‐implantable collamer lens implantation surgery

The retinal vasculature pathophysiological changes in vision recovery after treatment for indirect traumatic optic neuropathy patients

Imposed positive defocus changes choroidal blood flow in young human subjects

Contact Info

Product

Resources

About