Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa

Eysteinsson, Þór; Hardarson, Sveinn Hákon; Bragason, David; Stefánsson, Einar

doi:10.1111/aos.12359

Cited by 63 publications

(97 citation statements)

References 29 publications

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“…These results are different from those in previous studies, one of which examined 21 eyes of 11 RP patients and found that AS and VS were higher and AVS was lower in RP patients compared to control subjects [25]. Another study of 10 patients with advanced RP found increased VS in RP, but no significant difference in AS between RP and control subjects [24]. However, no previous studies have investigated retinal vessel oxygen saturation and diameter in different age groups.…”

Section: Discussioncontrasting

confidence: 73%

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Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa at various ages

Zong

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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Section: Discussioncontrasting

confidence: 73%

“…Previous studies have found increased venule saturation and decreased vessel diameter [24] and retinal oxygen saturation to be correlated with structural changes in the eyes of patients with RP [25].…”

Section: Introductionmentioning

confidence: 88%

Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa at various ages

Zong

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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“…17 In the pathology of eyes with RP, a reduction of the oxygen consumption due to photoreceptor cell loss has been suggested to cause oxygen diffusion from the choroidal vessels into the inner retina, which decreased the need for oxygen delivery from the retinal circulation. 21,22 This change of oxygen diffusion was assumed to cause an attenuation of the vessels, but the change of the caliber of the retinal capillary was not determined. We had expected the reduction of the caliber of the capillary vessels in the eyes of the RP patients, but the results were the reverse.…”

Section: Discussionmentioning

confidence: 99%

Quantification of Macular Microvascular Changes in Patients With Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

Inooka

Ueno

Kominami

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To evaluate the microvascular changes in eyes with RP quantitatively using optical coherence tomography angiography (OCTA) and to determine whether the correlations between these indices and the severity of RP are significant.METHODS. This was a retrospective, observational study. The medical records of 53 RP patients and 46 controls were reviewed. The OCTA images were obtained with the Cirrus 5000 with Angioplex, and an automated program was used to analyze the microvascular patterns. The perfusion density (PD) and vessel length density (VLD) were used as indices of the microvascular density, whereas the vessel diameter index (VDI) was used as a measure of the caliber of the vessels. The width of the ellipsoid zone (EZ) in the OCT images and the mean deviation (MD) of the Humphry Field Analyzer (HFA) were used to determine the severity of the RP. Student's t-tests and Spearman's correlation tests were used.RESULTS. Both the PD and VLD in the superficial and deep plexuses and the whole retina were significantly reduced, and the VDI was significantly increased in RP patients compared with the corresponding values of the controls (P < 0.001). Spearman's rank tests indicated the RP severity was significantly correlated with the PD and VLD in all three layers (P < 0.001, r ranging from 0.50 to 0.87) and significantly correlated with VDI in the deep and the whole retina (P < 0.001, ranging from À0.64 to À0.73).CONCLUSIONS. Quantitative changes in the microvascular density might be useful for examining the pathophysiology of RP.

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“…Eysteinsson et al. (2014) reported that decreased oxygen demand and increased venous saturation could trigger a decrease in retinal vessel diameter in patients with RP. Another factor which may reduce vessel density in RP is increased endothelin‐1 (ET‐1) level, which is the most potent vasoconstrictor of vessels (Masaki et al.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

Takagi

Hirami

Takahashi

et al. 2018

Acta Ophthalmologica

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PurposeTo investigate flow area changes measured using optical coherence tomography angiography (OCTA; RTVue XR Avanti®) in patients with retinitis pigmentosa (RP) with preserved visual acuity (VA).MethodsThis was an age‐ and refraction‐matched case–control study. Consecutive patients with a best‐corrected visual acuity (BCVA) of ≥20/20 and normal subjects were recruited. Fifty eyes (32 patients) and 22 eyes (12 controls) were included. The flow area and foveal avascular zone (FAZ) were measured in both superficial and deep layers within a 3 × 3 mm central area of the fovea. Association between OCTA parameters and the length of the inner segment ellipsoid (ISe) and external limiting membrane (ELM), the area without abnormal fluorescence in fundus autofluorescence (normal FAF area ratio) and the area of I‐2e of the Goldmann perimeter were analysed using mixed‐effects regression analysis.ResultsFoveal avascular zones were significantly smaller in patients with RP than in controls in superficial (p = 0.004) but not in deep layers (p = 0.25). The flow area in superficial (p = 0.007) and deep layers (p = 0.004) was significantly smaller in patients with RP than in controls. In patients with RP, flow areas in the superficial layers, but not in the deep layers, were significantly associated with the lengths of ISe (p = 0.001) and ELM (p = 0.002) and the I‐2e area (p = 0.036), but not with the normal FAF area ratio (p = 0.399).ConclusionOptical coherence tomography angiography (OCTA)‐measured flow area in superficial layers gradually reduced with RP progression and may be a useful parameter of RP pathogenesis.

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Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa

Cited by 63 publications

References 29 publications

Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa at various ages

Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa at various ages

Quantification of Macular Microvascular Changes in Patients With Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

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