Retinal VEGF levels correlate with ocular circulation measured by a laser speckle-micro system in an oxygen-induced retinopathy rat model

Matsumoto, Tadashi; Saito, Yuta; Itokawa, Takashi; Shiba, Tomoaki; Oba, Mari S.; Takahashi, Hiroki; Hori, Yuichi

doi:10.1007/s00417-017-3756-0

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…Nevertheless, our results are comparable with a study done by Ermakova et al on type 1 DM patients, which shows a relationship between the tear VEGF level and the degree of various manifestations of DR [37]. Tear VEGF levels may also be more representative of the ocular level of VEGF, as they are in closer proximity and share a similar circulation [38]. However, tear VEGF levels may be exposed to atmospheric changes.…”

Section: Discussionsupporting

confidence: 88%

Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients

et al. 2019

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Objective Detection of vascular endothelial growth factor (VEGF) levels in ocular tissue may perhaps provide insight into the role of VEGF in the pathogenesis and progression of diabetic retinopathy (DR). The aim of this study was to evaluate the levels of VEGF in tears and serum amongst type 2 diabetes mellitus (DM) patients. Methods A comparative cross-sectional study was conducted between August 2016 and May 2018 involving type 2 DM patients with no DR, non-proliferative DR (NPDR), and proliferative DR (PDR). Tear samples were collected using no.41 Whatman filter paper (Schirmer strips) and 5 mL blood samples were drawn by venous puncture. VEGF levels in tears and serum were measured by enzyme-linked immunosorbent assay. Results A total of 88 type 2 DM patients (no DR: 30 patients, NPDR: 28 patients, PDR: 30 patients) were included in the study. Mean tear VEGF levels were significantly higher in the NPDR and PDR groups (114.4 SD 52.5 pg/mL and 150.8 SD 49.7 pg/mL, respectively) compared to the no DR group (40.4 SD 26.5 pg/mL, p < 0.001). There was no significant difference in the mean serum VEGF levels between the three groups. There was a fair correlation between serum and tear VEGF levels ( p = 0.015, r = 0.263). Conclusion VEGF levels in tears were significantly higher amongst diabetic patients with DR compared to those without DR and were significantly associated with the severity of DR. There was a fair correlation between serum and tear VEGF levels. Detection of VEGF in tears is a good non-invasive predictor test for the severity of DR. A large cohort study is needed for further evaluation.

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Section: Discussionsupporting

confidence: 88%

Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients

et al. 2019

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“…However, a recent in-depth analysis of tear fluid using the Schirmer collection method revealed eight similar proteins previously found in the aqueous and vitreous humor, recognized exclusively for AMD 36 . We believe that the tear VEGF level reflects the ocular level of VEGF due to closer proximity and similar circulation 37 .…”

Section: Discussionmentioning

confidence: 91%

Evaluation of vascular endothelial growth factor (VEGF) level in the tears and serum of age-related macular degeneration patients

Shahidatul-Adha

Zunaina

Aini-Amalina

2022

Sci Rep

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Age-related macular degeneration (AMD) is an important cause of irreversible central blindness worldwide. Clinical manifestations range from asymptomatic in early and intermediate AMD to significant vision loss in late AMD. Approximately 10% of cases of early AMD eventually progress to the late advanced stage, influenced by the upregulation of vascular endothelial growth factor (VEGF). In this study, we evaluated VEGF concentration in the tears and serum of AMD patients. Our study revealed a significantly higher level of VEGF in the tears of patients with AMD compared with controls. The tear VEGF level has high sensitivity and specificity, and is significantly related to the severity of AMD, whilst serum VEGF level is non-specific and non-predictive of AMD severity. Thus, VEGF level in the tears may be used as a non-invasive biomarker for AMD progression. A large cohort study is needed for further verification.

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“…In addition, a meta-analysis suggested that polymorphisms in the angiotensin-converting enzyme (ACE) I/D may be a genetic biomarker of an increased risk of ROP ( 119 ). The mean blur rate (MBR) was higher in OIR rats than in the control group, and it was significantly correlated with avascular area/total retinal area (%AVA) and retinal VEGF, therefore, MBR could be used to assess the severity of OIR ( 120 ).…”

Section: Candidates Of Novel Potential Biomarkersmentioning

confidence: 99%

Novel Potential Biomarkers for Retinopathy of Prematurity

Tan

Wang

et al. 2022

Front. Med.

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Retinopathy of prematurity (ROP) is the main risk factor for vision-threatening disease in premature infants with low birth weight. An accumulating number of independent studies have focused on ROP pathogenesis and have demonstrated that laser photocoagulation therapy and/or anti-VEGF treatment are effective. However, early diagnosis of ROP is still critical. At present, the main method of ROP screening is based on binocular indirect ophthalmoscopy. However, the judgment of whether ROP occurs and whether treatment is necessary depends largely on ophthalmologists with a great deal of experience. Therefore, it is essential to develop a simple, accurate and effective diagnostic method. This review describes recent findings on novel biomarkers for the prediction, diagnosis and prognosis of ROP patients. The novel biomarkers were separated into the following categories: metabolites, cytokines and growth factors, non-coding RNAs, iconography, gut microbiota, oxidative stress biomarkers, and others. Biomarkers with high sensitivity and specificity are urgently needed for the clinical applications of ROP. In addition, using non-invasive or minimally invasive methods to obtain samples is also important. Our review provides an overview of potential biomarkers of ROP.

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Retinal VEGF levels correlate with ocular circulation measured by a laser speckle-micro system in an oxygen-induced retinopathy rat model

Cited by 7 publications

References 40 publications

Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients

Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients

Evaluation of vascular endothelial growth factor (VEGF) level in the tears and serum of age-related macular degeneration patients

Novel Potential Biomarkers for Retinopathy of Prematurity

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