Evaluation of vascular endothelial growth factor (VEGF) level in the tears and serum of age-related macular degeneration patients

Shahidatul-Adha, Mohamad; Zunaina, Embong; Aini-Amalina, Mazlan N.

doi:10.1038/s41598-022-08492-7

Cited by 19 publications

(8 citation statements)

References 46 publications

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“…Additionally, recently, VEGF levels in tears and serum were simultaneously measured in the same cohort of patients [ 69 ]. The cohort was composed of 108 individuals split into three categories (early AMD, late AMD and controls), each of which contained a third of the patients.…”

Section: Resultsmentioning

confidence: 99%

Recent Advances in Proteomics-Based Approaches to Studying Age-Related Macular Degeneration: A Systematic Review

García-Quintanilla

Rodríguez-Martínez²,

Bandín-Vilar

et al. 2022

IJMS

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Age-related macular degeneration (AMD) is a common ocular disease characterized by degeneration of the central area of the retina in the elderly population. Progression and response to treatment are influenced by genetic and non-genetic factors. Proteomics is a powerful tool to study, at the molecular level, the mechanisms underlying the progression of the disease, to identify new therapeutic targets and to establish biomarkers to monitor progression and treatment effectiveness. In this work, we systematically review the use of proteomics-based approaches for the study of the molecular mechanisms underlying the development of AMD, as well as the progression of the disease and on-treatment patient monitoring. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) reporting guidelines were followed. Proteomic approaches have identified key players in the onset of the disease, such as complement components and proteins involved in lipid metabolism and oxidative stress, but also in the progression to advanced stages, including factors related to extracellular matrix integrity and angiogenesis. Although anti-vascular endothelial growth factor (anti-VEGF)-based therapy has been crucial in the treatment of neovascular AMD, it is necessary to deepen our understanding of the underlying disease mechanisms to move forward to next-generation therapies for later-stage forms of this multifactorial disease.

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Section: Resultsmentioning

confidence: 99%

Recent Advances in Proteomics-Based Approaches to Studying Age-Related Macular Degeneration: A Systematic Review

García-Quintanilla

Rodríguez-Martínez²,

Bandín-Vilar

et al. 2022

IJMS

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“…Numerous studies have shown that the contents of tear uids not only re ect the health of the ocular surface but also provide insights into the intraocular environment [12,13]. VEGF concentrations in tear uid have been found to associate with the severity of macular edema in retinal vein occlusion [38], the clinical stage of diabetic retinopathy [39], and the severity of age-related macular degeneration [40]. As a result, it has proven useful in monitoring diseases involving angiogenesis in adult patients.…”

Section: Discussionmentioning

confidence: 99%

Tear Fluid Cytokine Analysis: A Non-Invasive Approach for Assessing Retinopathy of Prematurity Severity

Baba,

Uotani,

Inata

et al. 2023

Preprint

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Purpose: To determine whether there is a significant association between the inflammatory cytokines in the tear fluid and the severity of the Retinopathy of Prematurity Severity (ROP). Study Design: Retrospective cohort study. Methods: The cytokine levels in tear fluids were determined in 34 eyes with ROP and 18 eyes without ROP. There were 15 eyes with severe ROP requiring treatment and 19 eyes with mild ROP not requiring treatment. For severe ROP eyes, tear fluids were collected before treatment. Results: Significantly higher levels of CCL2 and VEGF were detected in eyes with severe ROP compared to eyes with mild ROP and no ROP. When assessed for cytokine levels that discriminate each disease group, CCL2 showed a significant odds ratio of 1.76 for severity change (/quintile, P = 0.032, after adjusting for birth weight). Correlation analysis showed that birth weight correlated with IL-1α levels, and decreased weight gain increased IFN-γ levels. We next determined tear fluid cytokines which discriminate severe ROP using receiver operating characteristics analysis. We show combination of higher CCL2 levels, higher VEGF levels, and lower IFN-γ levels in the tear fluid had a stronger predictive value for the severe ROP (area under curve, 0.85). Conclusion: The levels of CCL2, VEGF, and IFN-γ in tear fluid may serve as useful biomarkers for assessing the severity of ROP.

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“…No findings Yes [184] Yes [178] Yes [185] Treatment [186]. The increasing prevalence of DR is linked to the rise in cases of diabetes associated with the increasing prevalence of obesity and sedentary lifestyles [187].…”

Section: Vegfmentioning

confidence: 99%

Potential Retinal Biomarkers in Alzheimer’s Disease

García-Bermúdez,

Vohra,

Freude

et al. 2023

IJMS

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Alzheimer’s disease (AD) represents a major diagnostic challenge, as early detection is crucial for effective intervention. This review examines the diagnostic challenges facing current AD evaluations and explores the emerging field of retinal alterations as early indicators. Recognizing the potential of the retina as a noninvasive window to the brain, we emphasize the importance of identifying retinal biomarkers in the early stages of AD. However, the examination of AD is not without its challenges, as the similarities shared with other retinal diseases introduce complexity in the search for AD-specific markers. In this review, we address the relevance of using the retina for the early diagnosis of AD and the complex challenges associated with the search for AD-specific retinal biomarkers. We provide a comprehensive overview of the current landscape and highlight avenues for progress in AD diagnosis by retinal examination.

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Evaluation of vascular endothelial growth factor (VEGF) level in the tears and serum of age-related macular degeneration patients

Cited by 19 publications

References 46 publications

Recent Advances in Proteomics-Based Approaches to Studying Age-Related Macular Degeneration: A Systematic Review

Recent Advances in Proteomics-Based Approaches to Studying Age-Related Macular Degeneration: A Systematic Review

Tear Fluid Cytokine Analysis: A Non-Invasive Approach for Assessing Retinopathy of Prematurity Severity

Potential Retinal Biomarkers in Alzheimer’s Disease

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