Retinal Vasculitis Caused by Adult T-cell Leukemia/Lymphoma

Merle, H.; Donnio, A; Gonin, C; Jean-Charles, A; Panelatti, G.; Plumelle, Y.

doi:10.1007/s10384-004-0144-1

Cited by 25 publications

(10 citation statements)

References 15 publications

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“…ATL-related ocular diseases are rare (Kamoi and Mochizuki, 2012a), resulting in sporadic case reports. Analyzing such reports, ocular infiltration of ATL was the most frequent manifestation, observed in almost all tissues in and around the eye, and with reports mainly arising from Japan (Goto et al, 1993;Shibata et al, 1997;Mori et al, 2003;Yoshikawa et al, 2005;Miyamura et al, 2009;Liu et al, 2010;Maruyama et al, 2013;Hirano et al, 2017;Shimono et al, 2017;Sabundayo et al, 2018;Yamada et al, 2019), followed by Martinique (Merle et al, 2005(Merle et al, , 2016Fares et al, 2018) and the United States (Liu et al, 2010;Larson et al, 2012). In 2018, our nationwide survey in Japan confirmed that the most frequent ATL-related ocular manifestation was ATL infiltration (Kamoi et al, 2018).…”

Section: Atl and Ocular Diseasesupporting

confidence: 58%

HTLV-1 in Ophthalmology

Kamoi

2020

Front. Microbiol.

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Human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus described as a causative agent for human disease. In the field of ophthalmology, a close relationship between HTLV-1 infection and uveitis was identified through a series of clinical and laboratory studies in the late 1980s-1990s. Since then, HTLV-1-related ocular manifestations such as keratoconjunctivitis sicca, interstitial keratitis, optic neuritis and adult T-cell leukemia/lymphoma (ATL)-related ocular manifestations have continuously been reported. During the three decades since the association between HTLV-1 and ocular pathologies was discovered, ophthalmic practice and research have advanced with the incorporation of new technologies into the field of ophthalmology. Accordingly, new findings from recent research have provided many insights into HTLV-1-associated ocular diseases. Advanced molecular technologies such as multiplex polymerase chain reaction (PCR)/broad-range PCR using ocular samples have enabled rapid and accurate diagnosis. Advanced ophthalmic technologies such as widefield fundus camera and optical coherence tomography (OCT) have clarified various features of HTLV-1-associated ocular manifestations, and identified characteristics such as the "knob-like ATL cell multiple ocular infiltration" (KAMOI) sign. Advanced drug delivery methods such as intravitreal injection and sub-Tenon injection have led to progress in preventing disease progression. This article describes global topics and the latest research findings for HTLV-1-associated ocular diseases, with reference to a largescale nationwide survey of ophthalmologists. Current approaches and unmet needs for HTLV-1 infection in ophthalmology are also discussed.

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Section: Atl and Ocular Diseasesupporting

confidence: 58%

HTLV-1 in Ophthalmology

Kamoi

2020

Front. Microbiol.

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“…The highest prevalence is observed in Bahia, Maranha˜o and Para´; 4 however, the majority of publications are from Rio de Janeiro, Bahia and Sa˜o Paulo. The first cases, in Brazil, were 29 Panelatti et al, 30 Agapé et al, 31,a Besson et al, 32,a Merle et al 33 and Plumelle et al 34,35,a 63,d Freitas et al, 64,d Barbosa et al, 65,f Bittencourt et al 9,b;66,d;67,b,d;68b,d and Farre et al 69,b,d 1991 73,b;74,b Santos et al 75,b and Oliveira et al 76,d 1991 diagnosed in Rio de Janeiro by Pombo de Oliveira et al, 51 and four more papers were subsequently published in this state up till 2002. 16,53,[58][59][60] Thereafter, only one case was referred.…”

Section: Commentsmentioning

confidence: 99%

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

2016

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Adult T-cell leukemia/lymphoma (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1) which is endemic in countries of Caribbean and Central and South America. We performed a systematic search and review to identify publications on ATL in these countries to verify if this disease was getting recognition in these regions as well as the characteristics of the observed cases. The median age of 49.4 years was lower than that referred to in Japan. According to our findings in most Brazilian states and in some other countries, ATL is not being recognized and should be strongly considered in the differential diagnosis of T-cell leukemias/lymphomas. Failure to identify these cases may be due to the unsystematic realization of serology for HTLV-1 and phenotypic identification of non-Hodgkin lymphomas that may result from lack of resources. Detection of ATL cases has been more feasible with cooperation from foreign research centers. A huge effort should be made to improve the surveillance system for ATL diagnosis in most of the South- and Central-American and Caribbean countries, and this attitude should be embraced by public organs to support health professionals in this important task.

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“…23 Retinal sheathing, venous dilation and vasculitis, edema, folds, lesions, and exudates with cotton wool spots have also been seen. 24,25,27 Additionally, the retina may be affected by opportunistic infections such as cytomegalovirus retinitis. Such a case has been reported, and histological analysis showed cytomegalic cell infiltration and widespread retinal necrosis and disorganization.…”

Section: Case Reportmentioning

confidence: 99%

Ocular Manifestations and Pathology of Adult T-cell Leukemia/Lymphoma Associated with Human T-lymphotropic virus Type 1

et al. 2010

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The human T-cell lymphotropic virus type 1 (HTLV-1), endemic in defined geographical areas around the world, is recognized as the etiologic agent of adult T-cell leukemia/lymphoma (ATL), or HTLV-1. ATL is a rare adult onset T-cell malignancy that is characterized by the presence of ATL flower cells with T-cell markers, HTLV-1 antibodies in the serum, and monoclonal integration of HTLV-1 provirus in affected cells. Ocular manifestations associated with HTLV-1 virus infection have been reported and include HTLV-1 uveitis and keratoconjunctivitis sicca, but reports of ocular involvement in ATL are exceedingly rare. This article describes the ocular manifestations and pathology of ATL. We also report for the first time a case of a 34-year-old male with systemic ATL and prominent atypical lymphoid cell infiltration in the choroid. To our knowledge, this is the first report defining prominent choroidal involvement as a distinct ocular manifestation of ATL. ATL may masquerade as a variety of other conditions, and molecular techniques involving microdissection and PCR have proven to be critical diagnostic tools. International collaboration will be needed to better understand the presentation and diagnosis of this rare malignancy.

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Retinal Vasculitis Caused by Adult T-cell Leukemia/Lymphoma

Cited by 25 publications

References 15 publications

HTLV-1 in Ophthalmology

HTLV-1 in Ophthalmology

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

Ocular Manifestations and Pathology of Adult T-cell Leukemia/Lymphoma Associated with Human T-lymphotropic virus Type 1

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