Retinal vasculitis associated with cutaneous leukocytoclastic vasculitis

Basu, Soumyava; Mittal, Ruchi

doi:10.1007/s10792-017-0807-9

Cited by 3 publications

(5 citation statements)

References 5 publications

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“…Topical sCD83 treatment might inhibit the activation of DCs or trigger IDO expression in DCs, leading to suppressed T cell activation and infiltration, and thus reduces the damage of the eyes ( 28 , 40 ). However, we cannot exclude a more systemic effect since the eye is highly vascularized and drained by local lymph nodes ( 12 , 49 ). The mechanism of topical sCD83 treatment will be further elaborated in the future studies.…”

Section: Discussionmentioning

confidence: 99%

“…In this line, we show that sCD83 treatment leads to increased IDO and IL-10 expression in DCs, suggesting a shift to Treg induction. In addition, such tolerogenic DCs also might traffic through ocular compartments to the secondary lymphoid organs to promote systemic tolerance ( 5 , 49 ). Together, our data suggest that beneficial effects of sCD83 in EAU might be caused by a shift from stimulatory to tolerant DCs.…”

Section: Discussionmentioning

confidence: 99%

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Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells

et al. 2018

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Soluble CD83 (sCD83) is the extracellular domain of the membrane-bound CD83 molecule, and known for its immunoregulatory functions. Whether and how sCD83 participates in the pathogenesis of uveitis, a serious inflammatory disease of the eye that can cause visual disability and blindness, is unknown. By flow cytometry and imaging studies, we show that sCD83 alleviates experimental autoimmune uveitis (EAU) through a novel mechanism. During onset and recovery of EAU, the level of sCD83 rises in the serum and aqueous humor, and CD83+ leukocytes infiltrate the inflamed eye. Systemic or topical application of sCD83 exerts a protective effect by decreasing inflammatory cytokine expression, reducing ocular and splenic leukocyte including CD4+ T cells and dendritic cells (DCs). Mechanistically, sCD83 induces tolerogenic DCs by decreasing the synaptic expression of co-stimulatory molecules and hampering the calcium response in DCs. These changes are caused by a disruption of the cytoskeletal rearrangements at the DC–T cell contact zone, leading to altered localization of calcium microdomains and suppressed T-cell activation. Thus, the ability of sCD83 to modulate DC-mediated inflammation in the eye could be harnessed to develop new immunosuppressive therapeutics for autoimmune uveitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells

et al. 2018

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“… 12 In both studies, deposition of circulating immune complex had been suggested as a responsible mechanism of disease manifestation. 11 , 12 In this case, there were no systemic manifestations or abnormalities in blood evaluations to suggest an underlying systemic or infectious etiology. The response to IV methylprednisolone provided further support for an autoimmune process.…”

Section: Discussionmentioning

confidence: 67%

“… 22 Regarding the association of LCV and inflammatory ocular disease, Basu et al reported a case of retinal vasculitis, with the presentation of focal perivenular infiltrates and retinal hemorrhage, in a patient with LCV whose skin histology sample showed vessels with plump endothelial cells and neutrophilic infiltration and responded well to anti-inflammatory therapy. 11 In another study, Tsai et al described an LCV patient with the bilateral panuveitis and multifocal retinitis and vasculitis. 12 In both studies, deposition of circulating immune complex had been suggested as a responsible mechanism of disease manifestation.…”

Section: Discussionmentioning

confidence: 98%

“… 8 Although ophthalmic involvement in LCV is rare, there are several reports that describe ocular findings with this small-vessel vasculitis. Studies have reported iridocyclitis, 9 autoimmune keratolysis, 10 retinal vasculitis, 11 panuveitis, 12 multifocal retinitis, 12 chronic iritis, 13 bilateral episcleritis, 14 chemosis, 12 marginal corneal ulcers, 12 subconjunctival hemorrhage, 12 and central serous chorioretinopathy (CSCR) 15 in LCV patients.…”

Section: Introductionmentioning

confidence: 99%

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Impending central retinal vein occlusion in patient with idiopathic cutaneous leukocytoclastic vasculitis

Akhavanrezayat

Hien

Pham

et al. 2020

American Journal of Ophthalmology Case Reports

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Purpose To report a case of impending central retinal vein occlusion (CRVO) associated with idiopathic cutaneous leukocytoclastic vasculitis (LCV) that demonstrated significant resolution following treatment with intravenous (IV) methylprednisolone. Observations A 27-year-old man presented to a tertiary Uveitis Clinic with a five-day history of blurry vision in the right eye (OD). He had a history of a purpuric rash and arthralgias five years ago and a biopsy-confirmed diagnosis of LCV controlled with colchicine two years ago in India. Recently, he presented with a recurrent rash and severe abdominal pain. After being evaluated by rheumatology and gastroenterology, he was placed on Helicobacter pylori treatment and high dose oral prednisone, which improved his skin and gastrointestinal symptoms. At the first ophthalmic exam, his systemic findings included lower extremity purpura. His best-corrected visual acuity (BCVA) was 20/20 in both eyes (OU). Slit-lamp examination revealed no cells or flare in OU. Dilated fundus exam showed mild enlarged, tortuous veins, optic nerve hemorrhage, and intraretinal hemorrhages temporal to the macula in OD. Spectral-domain optical coherence tomography (SD-OCT) demonstrated multiple hyper-reflective, plaque-like lesions involving the inner nuclear layer, consistent with paracentral acute middle maculopathy (PAMM). The patient was diagnosed with impending central retinal vein occlusion (CRVO) in OD. Laboratory evaluations were unremarkable. Aspirin was initially started for the patient but was later held due to the worsening of retinal hemorrhage and retinal vein tortuosity at the one-week follow-up. The patient then received three doses of intravenous methylprednisolone, followed by systemic oral prednisone and mycophenolate mofetil. One month later, retinal hemorrhages, venous stasis, and skin manifestations resolved. Conclusion and importance Ocular involvement in LCV is rare and may present with different manifestations. The index case is the first report of impending CRVO in a patient with idiopathic LCV and without any other known risk factors for CRVO. Our report not only describes the unique course of LCV-related ocular involvement, but also introduces and underscores a potentially effective therapeutic plan.

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Case of both rivaroxaban- and dabigatran-induced leukocytoclastic vasculitis, during management of pulmonary thromboembolism

Lee

Kim

et al. 2019

Respiratory Medicine Case Reports

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Leukocytoclastic vasculitis is a disorder characterized by neutrophilic inflammation that is predominantly limited to the superficial cutaneous postcapillary venules. This condition may be idiopathic or may have a defined cause. Rivaroxaban and dabigatran have been widely used as warfarin alternatives, because of their efficacy and safety. In this case report, we describe a case of leukocytoclastic vasculitis induced by both rivaroxaban- and dabigatran-, which developed during the management of pulmonary thromboembolism.

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Retinal vasculitis associated with cutaneous leukocytoclastic vasculitis

Abstract: We have reported the first case of clinically manifest retinal vasculitis, associated with a common form of cutaneous vasculitis.

Cited by 3 publications

References 5 publications

Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells

Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells

Impending central retinal vein occlusion in patient with idiopathic cutaneous leukocytoclastic vasculitis

Case of both rivaroxaban- and dabigatran-induced leukocytoclastic vasculitis, during management of pulmonary thromboembolism

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