Retinal vascular diameter in young subjects with a vasospastic propensity

Branca, F; Orgül, Selim; Zawinka, Claudia; Reinhard, G.

doi:10.1007/s00417-005-0101-9

Cited by 8 publications

(6 citation statements)

References 40 publications

(41 reference statements)

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“…Gasser et al testified, in glaucoma patients, the blood flow velocities in nailfold capillary were associated with the velocities ophthalmic artery ( Gasser et al, 1999 ). For retinal vascular diameter, Branca et al (2006) did not find the retinal arteriole or retinal venule diameters in subjects with vasospastic propensity were smaller than retinal vessels in subjects without vasospastic propensity. Kochkorov et al (2006) got the similar results about retinal vascular diameter, whereas they further attested healthy vasospastic subjects had higher retinal spatial irregularity and an increased vessel diameter variation in heartbeat.…”

Section: Discussioncontrasting

confidence: 56%

The Relationship Between Nailfold Microcirculation and Retinal Microcirculation in Healthy Subjects

Tian

Xie

et al. 2020

Front. Physiol.

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Objective To evaluate whether the nailfold microcirculation is associated with retinal microcirculation in healthy subjects. Methods Fifty subjects without systematic and ocular diseases were enrolled. Thickness of peripapillary retinal nerve fiber layer (RNFL), vessel density (VD) of radial peripapillary capillaries (RPCs), and superficial capillary VD in macular zone were measured with optical coherence tomography angiography (OCTA) in left eyes. Nailfold microcirculation, including capillary density, avascular zones, dilated capillaries, and hemorrhages was examined on the fourth digit of each subject’s non-dominant (left) hand with nailfold capillaroscopy (NFC). Results After adjustment for relatively systemic factors, multivariate regression analyses showed a significant direct relationship between RNFL thickness and nailfold capillary density (OR = 1.09; p = 0.046). RNFL thickness and RPCs VD were negatively correlated with nailfold avascular zones (OR = 0.855; p = 0.007; OR = 0.596; p = 0.010). Superficial VD of parafovea was negatively associated with dilated nailfold capillaries (OR = 0.794; p = 0.012). Conclusion In healthy subjects, nailfold capillary lower density and abnormalities are associated with reduced RNFL thickness and retinal VD. The results provide a theoretical foundation for relevant studies on ocular diseases with microvascular abnormalities and could contribute to pathogenesis understanding in the future. NFC and OCTA have the potential to identify risk factors and improve accuracy of the early diagnosis and treatment of ocular diseases, even systemic diseases with any microvascular component in clinical practice. Clinical Trail Registration http://www.chictr.org.cn/index.aspx , identifier ChiCTR 1800017875.

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Section: Discussioncontrasting

confidence: 56%

The Relationship Between Nailfold Microcirculation and Retinal Microcirculation in Healthy Subjects

Tian

Xie

et al. 2020

Front. Physiol.

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“…The vascular endotheliopathy, as a vasospastic propensity, is often associated with vasospastic syndrome, especially in woman, leading to retinal venous occlusion, ischaemic neuropathy, migraines and central serous chorioretinopathy. In this group of patients, both a low perfusion pressure and an increase in intraocular pressure as well as the phenomenon of reperfusion may cause changes in the optic nerve [27].…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in retrobulbar circulation: a literature review

2019

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Introduction The advances in research methods used in ophthalmology allow for an increasingly accurate examination of the eyes, as well as the morphology and function of the vessels. Colour Doppler imaging is still the first-line method for the analysis of parameters of retrobulbar circulation. Therefore, the aim of this work was to present the current state of knowledge about anatomical and functional age-related changes in retrobulbar arteries. Methods A literature search was performed mainly based on the PubMed database. Results The anatomy of retrobulbar arteries, histological background of age-related vascular changes, age-related changes in retrobulbar blood flow in the ophthalmic artery, central retinal artery, short posterior ciliary arteries, and the reference values for the age-dependent retrobulbar circulation parameters measured by colour Doppler imaging are discussed in this review. Conclusion The age of the subject should always be taken into account when interpreting the parameters of retrobulbar blood flow measured by colour Doppler imaging.

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“…Retinal vessels in vasospastic subjects are inherently neither constricted nor dilated at baseline: we did not observe any differences in original (first) baselines compared with nonvasospastic subjects, confirming previous results. 26 Nevertheless, immediately after responding to a challenge, in this case a flicker stimulation, the vessels tended to become more constricted. A regression to the mean is unlikely, as the baseline conditions were strictly stan-dardized in all participants.…”

Section: Discussionmentioning

confidence: 99%

“…Retinal vessel diameter at the baseline is statistically comparable between vasospastic and control subjects. 26 Therefore, a provocation test such as flicker light stimulation may be more suitable for identifying and further describing vascular dysregulation in the ocular circulation. In the present study, we analyzed maximum dilation of retinal vessels in response to flicker light stimulation with the RVA.…”

mentioning

confidence: 99%

Analysis of Retinal Vasodilation after Flicker Light Stimulation in Relation to Vasospastic Propensity

Gugleta¹,

Zawinka²,

Rickenbacher³

et al. 2006

Invest. Ophthalmol. Vis. Sci.

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The maximum dilatory amplitude was significantly lower in vessels in the vasospastic group. An augmentation of the maximum vasodilation was observed in the nonvasospastic group after repeated flicker stimulations, a phenomenon that was missing in arterioles of vasospastic subjects. It seems that such different behavior is due to the opposite baseline offsets in interflicker periods in the two groups.

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Retinal vascular diameter in young subjects with a vasospastic propensity

Cited by 8 publications

References 40 publications

The Relationship Between Nailfold Microcirculation and Retinal Microcirculation in Healthy Subjects

The Relationship Between Nailfold Microcirculation and Retinal Microcirculation in Healthy Subjects

Age-related changes in retrobulbar circulation: a literature review

Analysis of Retinal Vasodilation after Flicker Light Stimulation in Relation to Vasospastic Propensity

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