Retinal pigment epithelium hyperplasia overlying pigment epithelial detachment in age-related macular degeneration can masquerade as neovascularization on optical coherence tomography angiography

Chen, Ling; Zhang, Xiongze; Gan, Yuhong; Liu, Bing; Zhang, Yuxin; Wen, Feng

doi:10.1007/s00417-018-4138-y

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…It was observed in the present study that the mean age of the patients in the study group was significantly higher than in the control group, as well as the means of the superficial FAZ areas of both eyes. Thus, it can not be affirmed that the increase in FAZ was observed due to arterial hypertension, since with increasing age there is a decrease in vascular density of the retina and an increase in FAZ in both the superficial and deep plexuses [24][25][26].…”

Section: Discussionmentioning

confidence: 97%

“…However, such enlargement is not easily interpreted, since there is variation in the size of this area also in the general population, since in a single individual this measurement can usually be large or abnormally increased. Thus, given its individual variation, a personalized evaluation of the same and its relationships with the other layers of the retina is suggested [24].…”

Section: Discussionmentioning

confidence: 99%

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Foveal Avascular Zone in Hypertension as Measured by Optical Coherence Tomography Angiography

Sá¹,

Gadelha²,

Melo³

et al. 2019

CTOY

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Purpose: To investigate the Foveal Avascular Zone (FAZ) area in patients with arterial hypertension using optical coherence tomography angiography (OCT-A).Material and methods: The study was permormed at the School Clinic of UNIFACISA and at the Eye Care Center. It was included 21 hypertensive patients (study group) and 19 individuals without hypertension (control group). It was excluded patientes with diabetes or glaucoma. The measurement of the FAZ areas was performed by the DRI OCT-1Triton/Plus. For the quantitative variables, the results were expressed by their means and standard deviations. Qualitative variables were expressed by their absolute and relative frequencies. Student’s t-test was used to verify differences between means and Fisher’s exact test for differences between frequencies. For evaluating the correlation between the superficial and deep plexus areas, the Pearson correlation test was used. P value ≤ 0.05, rejected the null hypothesis. The research was approved by the Ethics Committee of the Medical School from Campina Grande -UNIFACISA and all individuals signed the free and informed consent form.Results: The means of the superficial FAZ of both eyes was significantly higher in the study group (right eye 410.7 ± 160.7 μm2 - 319.1 ± 108.2 μm2 - p = 0.0433); (left eye: 405.4 ± 144.8 μm2 versus 309.4 ± 87.7 μm2- p = 0.0174). The means of the deep FAZ areas of the right and left eyes were similar between the study and control groups (right eye: 559.6 ± 253.28 μm2 versus 605.1 ± 226.8 μm2 - p = 0.5548); (left eye: 673.2 ± 170.8 μm2 versus 585.6 ± 171.2 μm2 - p = 0.1142). The relationships between the superficial and deep plexus areas of both eyes showed a weak correlation between the two plexuses. (r = 0.4734), left eye (r = 0.2287), study group - right eye: (r = 0.4374), left eye (r = 0.3580).Conclusion: The area of superficial FAZ of the right and left eyes was significantly higher in the hypertensive patients. The deep FAZ area of both eyes, however showed similar mean areas between the study and control groups.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Foveal Avascular Zone in Hypertension as Measured by Optical Coherence Tomography Angiography

Sá¹,

Gadelha²,

Melo³

et al. 2019

CTOY

View full text Add to dashboard Cite

show abstract

“…We applied the RPE-fit segmentation strategy combined with manual adjust, given polypoidal lesions located between the Bruch membrane and RPE. This segmentation strategy also eliminated the masking artifacts due to hyperreflective material overlying or within the PED [49,50]. In addition, focal RPE atrophy that accompanied by PED gave rise to unmasking artifacts [49].…”

Section: Discussionmentioning

confidence: 99%

Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography?

Wang

Jia

et al. 2021

Eye

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Purpose To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomographic angiography (SS-OCTA) to identify polypoidal lesions in serous or serosanguinous maculopathy. Materials and methods A retrospective review of patients presenting pigment epithelial detachments (PEDs) with the diagnosis of polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD), and central serous chorioretinopathy (CSC), all of which underwent SD-OCT, SS-OCTA, and indocyanine green angiography (ICGA). Typical features of polypoidal lesions on SD-OCT included sharply peaked PED, notched PED, and hyperreflective ring underneath PED. SS-OCTA feature was vascularized PEDs on cross-sectional images corresponding to cluster-like structures on en face images. The parameters of PEDs were measured for analysis. Results Of 72 eyes, 30 had PCV, 22 had nAMD, and 20 had CSC. A total of 128 localized PEDs were detected on SD-OCT. Typical features on SD-OCT had a high specificity (94.0%) but a limited sensitivity (73.8%). SS-OCTA features provided a higher sensitivity (96.7%). PEDs of the polypoidal lesions unrecognized by SD-OCT were dome-shaped, with smaller ratio of height to base diameter and less area, and almost had heterogeneous internal reflectivity and a connected double-layer sign. Some lesions misidentified by SS-OCTA developed into ICGA-proven polypoidal lesions at follow-up visits. Conclusion A small dome-shaped PED with heterogeneous internal reflectivity and a connected double-layer sign on SD-OCT may suggest a polypoidal lesion of PCV. SS-OCTA may be a helpful tool to investigate preclinical PCV and observe the formation of polypoidal lesions.

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“…[32] Chen et al demonstrated that RPE hyperplasia overlying PED may cause false flow signal in deeper layers. [33] Projection artifact can be used to examine the anatomy of the choroidal vessels. By moving and placing the segmentation line behind the choroid, the vascular pattern of choroidal vessels can be projected onto the sclera.…”

Section: Misidentification Of Retinal Layers (Segmentation Artifact)mentioning

confidence: 99%

Artifacts in Optical Coherence Tomography Angiography

Anvari

Ashrafkhorasani

Habibi

et al. 2021

JOVR

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We performed a comprehensive search of the published literature in PubMed and Google Scholar to identify types, prevalence, etiology, clinical impact, and current methods for correction of various artifacts in optical coherence tomography angiography (OCTA) images. We found that the prevalence of OCTA image artifacts is fairly high. Artifacts associated with eye motion, misidentification of retinal layers, projections, and low optical coherence tomography signal are the most prevalent types. Artifacts in OCTA images are the major limitations of this diagnostic modality in clinical practice and identification of these artifacts and measures to mitigate them are essential for correct diagnosis and follow-up of patients.

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Retinal pigment epithelium hyperplasia overlying pigment epithelial detachment in age-related macular degeneration can masquerade as neovascularization on optical coherence tomography angiography

Cited by 7 publications

References 24 publications

Foveal Avascular Zone in Hypertension as Measured by Optical Coherence Tomography Angiography

Foveal Avascular Zone in Hypertension as Measured by Optical Coherence Tomography Angiography

Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography?

Artifacts in Optical Coherence Tomography Angiography

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