Chitinase-3-like-1 promotes M2 macrophage differentiation and induces choroidal neovascularization in neovascular age-related macular degeneration.

IMPORTANCE Polypoidal choroidal vasculopathy (PCV) is a major cause of visual loss worldwide, particularly in Asia, and the appropriate understanding of the structures in PCV previously described as polypoidal lesions is important for understanding their pathogenesis, diagnosis, and prognosis. OBJECTIVE To report the morphologic characteristics of polypoidal lesions and their association with branching vascular networks (BVNs) in eyes with PCV using swept-source optical coherence tomographic angiography (SS-OCTA). DESIGN, SETTING, AND PARTICIPANTS This cross-sectional observational study included 20 participants recruited from Shanghai General Hospital with a diagnosis of PCV based on the presence of focal hyperfluorescent spots on indocyanine green angiography (ICGA). Data were collected from

Age-related macular degeneration (AMD), characterized by the development of choroidal neovascularization (CNV), is a leading cause of vision deterioration in adults over age 50 1 . An angiogenic growth factor vascular endothelial growth factor A (VEGFA) plays a Downloaded from https://academic.oup.com/nsr/advance-article-abstract/doi/10.1093/nsr/nwaa033/5775464 by guest on 16 March 2020