Retinal Pigment Epithelium Function in Alopecia Areata

Tosti, Antonella; Colombati, S; Padova, Maria Pia De; Guidi, Simonetta Guidelli; Tosti, Giovanni; Maccolini, E.

doi:10.1111/1523-1747.ep12355013

Cited by 21 publications

(26 citation statements)

References 10 publications

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“…Unspecific lens opacification can be seen in patients with atopic dermatitis, patients receiving systemic and topical steroids, those with diabetes mellitus, and elderly patients. Incidences of lens opacification of 3–27% have been reported in the general population …”

Section: Discussionmentioning

confidence: 99%

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Ocular findings in patients with alopecia areata

et al. 2016

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Section: Discussionmentioning

confidence: 99%

“…Several studies on retinopathies in patients with AA have been reported in the literature . Some of those studies referred to the findings of fundus fluorescein angiography (FFA) .…”

Section: Discussionmentioning

confidence: 99%

Ocular findings in patients with alopecia areata

et al. 2016

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“…However, there are contrasting opinions on the significance of these lenticular changes 3–6 . Involvement of the chorioretina in the form of drusen and pigmentary abnormalities has been documented 3,4,7 . Ultraviolet light and oxidative stress have been implicated in the etiopathogenesis of cataract 8 .…”

Section: Introductionmentioning

confidence: 99%

Ocular alterations in patients of alopecia areata

Pandhi¹,

Singal²,

Gupta³

et al. 2009

The Journal of Dermatology

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There is paucity of published work on ocular alterations in patients of alopecia areata (AA), especially from the Asian continent. We studied the clinical profile of 83 patients of AA and 80 sex- and age-matched controls to assess and compare the ocular changes, namely punctate opacities, cataract, intraocular tension and retinal changes. The outcome was analyzed with respect to prevalence of atopy, concomitant personal or family history of autoimmune diseases and nail changes in both the groups. The prevalence of atopy and family history of autoimmune diseases was significantly higher in the patient group. Lenticular changes were observed in 40.9% patients (including cataract in 16.9%) and 11.2% controls (P < 0.005). Within the patient group, lenticular involvement occurred with increased frequency in atopics (P = 0.034) and in the presence of family history of autoimmune diseases (P < 0.05). Retinal changes in the form of degenerative changes, pigmentary clumping and abnormal vascular changes were more prevalent (P < 0.001) in the study group. As the ocular changes were not found to correlate with the age, severity or extent of the disease, an initial ophthalmological screening of all patients is suggested.

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“…Investigações clínicas e laboratoriais não evidenciaram quaisquer alterações citadas acima; o exame biomicroscópico e a angiografia normais pressupõem, desta maneira, que o potencial oscilatório do exame não reflete, neste paciente, uma alte- Electroretinogram ração patológica, já que as outras etapas do ERG e a investigação clínica e oftalmológica foram normais. Conclui-se que do ponto de vista eletrofisiológico, os pacientes heterozigotos examinados (casos II-19 e III-20) não afetados ocularmente, mas com alterações capilares, não são portadores de alterações a nível da retina, ao contrário de pacientes com alopécia e sem problemas oculares em que se evidenciaram alterações no EOG (15) . A hipótese inicial para os pacientes afetados (Figura 1 -caso III-21, III-22, III-23 e III-24), foi a de retinite pigmentosa inversa, que é caracterizada por uma concentração anormal de pigmentos, envolvendo a mácula, que pode cursar com estreitamento dos vasos retinianos e palidez do disco óptico (16) .…”

Section: Discussionunclassified