Retinal nerve fibre layer imaging compared with histological measurements in a human eye

Blumenthal, Eytan Z.; Parikh, Rajul; Pe’er, Jacob; Naik, Milind N.; Kaliner, Ehud; Cohen, Matan J.; Prabakaran, S.; Kogan, Michael; Thomas, Ravi

doi:10.1038/sj.eye.6702942

Cited by 51 publications

(37 citation statements)

References 11 publications

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“…The RNFL would be measured at similar distances from the centre of the disc, regardless of the size of the scleral canal. Blumenthal et al 16 also recently found RNFL thickness to be inversely related to the distance from the centre of the optic disc.…”

Section: Discussionmentioning

confidence: 89%

Fixed-diameter scan protocol preferable for retinal nerve fibre layer measurement by optical coherence tomography in all sizes of optic discs

Kaushik

Pandav²,

Ichhpujani³

et al. 2009

British Journal of Ophthalmology

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In normal subjects, disc size does not appear to affect RNFL measurements by OCT using the fixed-diameter protocol, thus indicating that RNFL thickness may be related to distance from the centre of the optic disc rather than the margin. The thicker RNFL observed in large glaucomatous discs in this study may be related to the earlier stage of glaucoma, though it may not apply to the general population.

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Section: Discussionmentioning

confidence: 89%

Fixed-diameter scan protocol preferable for retinal nerve fibre layer measurement by optical coherence tomography in all sizes of optic discs

Kaushik

Pandav²,

Ichhpujani³

et al. 2009

British Journal of Ophthalmology

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“…[7][8][9] Moreover, their measurements have been shown to correlate positively with ex vivo histological measurements of the retina. 10,11 Spectral-domain OCT (SD-OCT) has now replaced TD-OCT and a large number of instruments by different manufacturers are commercially available. This technology provides increased axial resolution and scanning speed as it records the interferometric information using a spectrometric method instead of adjusting the position of a reference mirror.…”

Section: Introductionmentioning

confidence: 99%

Effect of pupil dilation on retinal nerve fibre layer thickness measurements and their repeatability with Cirrus HD-OCT

Savini

Carbonelli²,

Parisi

et al. 2010

Eye

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“…12,13 The spectral-domain OCT technique demonstrates axial resolution in the range of few microns and allows clear visualization of individual retinal layers, 14 -16 allowing evaluation of retinal transsynaptic degeneration in vivo.…”

mentioning

confidence: 99%

Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study

Sriram

Graham

Wang³

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.Recently demonstrated neuronal loss in the inner nuclear layer of the retina in multiple sclerosis (MS) and glaucoma raises the question of a primary (possibly immune-mediated) or secondary (transsynaptic) mechanism of retinal damage in these diseases. In the present study we used optical coherence tomography to investigate retrograde retinal transsynaptic degeneration in patients with long-standing and severe loss of ganglion cells due to optic neuropathy. METHODS. Fifteen eyes of glaucoma patients with visual field defect limited to upper hemifield and 15 eyes of MS patients with previous episode of optic neuritis (ON) and extensive loss of ganglion cells were imaged using spectral-domain optical coherence tomography and compared with two groups of age-matched controls. Combined retinal ganglion cell layer/ inner plexiform layer (GCL/IPL) thickness and inner nuclear layer (INL) thickness were analyzed. RESULTS. In the glaucoma group there was a significant (P ϭ 0.0005) reduction of GCL/IPL thickness in the lower (affected) retina compared with normal controls; however INL thickness was not statistically reduced (P ϭ 0.49). In the MS group reduction of GCL/IPL thickness in both hemifields of ON eyes was also significant (P ϭ 0.0001 and P Ͻ 0.0001 for inferior and superior retina respectively). However, similar to the glaucomatous eyes, there was no significant reduction of INL thickness in both hemifields (P ϭ 0.25 and P ϭ 0.45). CONCLUSIONS. This study demonstrates no significant loss of INL thickness in parts of the retina with long-standing and severe loss of retinal ganglion cells. (Invest Ophthalmol Vis Sci.

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Retinal nerve fibre layer imaging compared with histological measurements in a human eye

Cited by 51 publications

References 11 publications

Fixed-diameter scan protocol preferable for retinal nerve fibre layer measurement by optical coherence tomography in all sizes of optic discs

Fixed-diameter scan protocol preferable for retinal nerve fibre layer measurement by optical coherence tomography in all sizes of optic discs

Effect of pupil dilation on retinal nerve fibre layer thickness measurements and their repeatability with Cirrus HD-OCT

Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study

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