Effect of pupil dilation on retinal nerve fibre layer thickness measurements and their repeatability with Cirrus HD-OCT

Comparison of measurement error of Cirrus HD-OCT and Heidelberg Retina Tomograph 3 in patients with early glaucomatous visual field defect

“…For example, according to our data the relatively small 5-μm change in average RNFL thickness (6 μm if we account for CI) could be a significant sign of early POAG progression when measured by the same operator on Cirrus HD-OCT. This is in close agreement with the results of other studies [8][9][10][11]14]. Repeatability data for other Cirrus HD-OCT and HRT3 parameters shown in Table 1 could be used for evaluation of other changes seen in a patient with early POAG or suspected POAG.…”

“…The coefficient of variation of average RNFL thickness in healthy and glaucomatous persons varies mostly from 1.4 to 3.0% [8][9][10][11]14]. Only a few authors have shown worse data (4.3-4.5% or more) [12,13].…”

“…The scan protocol was "Optic Disc Cube 200× 200" analyzed by "RNFL Thickness Analysis". Data acquisition and analysis software of Cirrus HD-OCT has been described in detail by many authors [8][9][10][11][12]. The analysis protocol is fully automatic, and does not need manual corrections.…”

“…There are several studies of repeatability and variability of stereometric parameters of the optic disc and retinal nerve fiber layer (RNFL) measurements by CSLO with Heidelberg Retina Tomograph (HRT) [1][2][3][4][5][6][7], but their results are sometimes conflicting. A number of recent studies [8][9][10][11][12][13][14] have dealt with repeatability and variability of RNFL measurements by SD-OCT with Cirrus HD-OCT [8][9][10][11][12] or other instruments [13,14], but to our knowledge no comparison with HRT was performed. The purpose of the present study was to compare the intrasession intraoperator and interoperator repeatability and within-subject coefficients of variation of measurements of the RNFL by Cirrus HD-OCT and stereometric parameters of the optic nerve head (ONH) and RNFL by HRT3 in patients with early glaucomatous visual field defect.…”

Diagnostic ability of retinal ganglion cell complex, retinal nerve fiber layer, and optic nerve head measurements by Fourier-domain optical coherence tomography

“…Results reported by other authors [15,16] and our own findings (poster at ARVO 2010) showed no influence of pupil dilation on RNFL measurements. Limitations of the automatic measurements without pupil dilation include constricted pupils, dry eye syndrome, as well as a high rate of blink and corneal or lens opacities.…”