Retinal Nerve Fiber Layer Thickness, Brain Atrophy, and Disability in Multiple Sclerosis Patients

Abalo-Lojo, José Manuel; Limeres, Carmen Carollo; Gómez, Manuel; Baleato-González, Sandra; Cadarso-Suárez, Carmen; Capeáns-Tomé, Carmen; González, Francisco

doi:10.1097/wno.0000000000000057

Cited by 65 publications

(57 citation statements)

References 19 publications

(9 reference statements)

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“…Several studies have observed a relationship between OCT measurements and EDSS score or disease duration [16,18,23,24,25]. Our results indicated no correlation between choroidal thickness and EDSS score, however a significant inverse correlation was detected between choroidal thickness and disease duration.…”

Section: Discussioncontrasting

confidence: 50%

“…We also confirmed the results of previous studies that indicate a tendency of RNFL atrophy to be greater in ON-affected eyes than in unaffected eyes [20,21,22]. Previous studies reported that RNFL thickness was correlated with functional and structural measures of MS such as visual acuity, visual field, low-contrast letter acuity, contrast sensitivity, color vision, visual evoked potentials, brain atrophy assessed by magnetic resonance imaging and even quality of life [16,23,24,25,26]. In our study no correlation was found between RNFL and choroidal thickness measurements in both MS ON and MS non-ON eyes.…”

Section: Discussionmentioning

confidence: 80%

“…Disease duration and neurological disability are assumed as two clinical parameters linked with progressive axonal loss [24]. Several studies have observed a relationship between OCT measurements and EDSS score or disease duration [16,18,23,24,25].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Choroidal Vascular Changes in Patients with Multiple Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography

et al. 2015

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Objective: To evaluate the choroidal thickness in patients with multiple sclerosis (MS) using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: In this observational comparative study, 68 eyes of 34 MS patients and 60 eyes of 30 healthy subjects were evaluated. All participants underwent complete ophthalmologic examination and OCT scanning. Choroidal thickness measurements were performed at seven points. Results: The mean subfoveal choroidal thickness was reduced significantly in MS patients (310.71 ± 61.85 μm) versus healthy controls (364.85 ± 41.81 μm) (p < 0.001). The difference was also significant at all six measurement points (p < 0.001 for all). Choroidal thickness measurements revealed no significant difference between MS eyes with a prior optic neuritis (ON) history (MS ON) and those without ON history (MS non-ON). Subfoveal choroidal thickness did not correlate with retinal nerve fiber layer and Expanded Disability Status Scale score, but reduced choroidal thickness was associated with longer disease duration (r = -0.28, p = 0.019) in MS patients. Conclusion: In MS patients, choroidal structural changes occur both in MS ON and MS non-ON eyes. The decreased choroidal thickness might provide evidence to support a potential role of vascular dysregulation in the pathophysiology of MS.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 80%

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Evaluation of Choroidal Vascular Changes in Patients with Multiple Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography

et al. 2015

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“…All of these OCT parameters have been associated with MS disability 7,8 and brain atrophy 7,9 and for this reason its application offers the promise of being used as an imaging surrogate of the MS disease course.…”

Section: Introductionmentioning

confidence: 99%

Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

Martínez-Lapiscina

Arnow

Wilson

et al. 2016

The Lancet Neurology

284

233

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“…It can measure the thickness of the retinal nerve fibre layer and the ganglion cell layer. Retinal axonal loss, regardless of clinical history of optic neuritis, may be a good marker of clinical disability in MS [135][136][137][138][139] and correlates with brain atrophy [140,141].…”

Section: Octmentioning

confidence: 99%

Secondary Progressive Multiple Sclerosis: Definition and Measurement

et al. 2016

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Secondary progressive multiple sclerosis (SPMS) is diagnosed retrospectively and involves a clinical course characterized by a progressive accumulation of neurological disability, independent of relapses, following an initial relapsing-remitting (RR) phase. Our incomplete understanding of the pathological mechanisms underlying neurodegeneration in multiple sclerosis (MS) may explain why, to date, there is no definitive imaging or laboratory test that is able to inform us when the disease is clearly entering into a progressive phase and why the vast majority of clinical trials testing immunosuppressant and immunomodulating drugs in SPMS patients has so far yielded disappointing or mixed results. Here we discuss the definition(s) of SPMS and how it may vary, outcome measurements (current and emerging) and modern trial design.

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Retinal Nerve Fiber Layer Thickness, Brain Atrophy, and Disability in Multiple Sclerosis Patients

Abstract: This study shows that RNFL thickness correlates with BCR and with MS subtypes. Additionally, our study indicates that OCT is better suited for MS assessment than GDx. We conclude that the damage of retinal axons appears related to brain damage in patients with MS.

Cited by 65 publications

References 19 publications

Evaluation of Choroidal Vascular Changes in Patients with Multiple Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography

Evaluation of Choroidal Vascular Changes in Patients with Multiple Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography

Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

Secondary Progressive Multiple Sclerosis: Definition and Measurement

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