Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

Martínez-Lapiscina, Elena H.; Arnow, Sam; Wilson, James; Saidha, Shiv; Preiningerová, Jana Lízrová; Oberwahrenbrock, Timm; Brandt, Alexander U.; Pablo, L.; Guerrieri, Simone; González, Inés García; Outteryck, Olivier; Mueller, Ann Kristin; Albrecht, Phillip J.; Chan, Wesley; Lukas, Sebastian; Balk, Lisanne J.; Fraser, Clare L.; Frederiksen, Jette Lautrup; Resto, Jennifer; Frohman, Teresa C.; Cordano, Christian; Zubizarreta, Irati; Andorrà, Magí; Sánchez-Dalmau, Bernardo; Sáiz, Albert; Bermel, Robert; Klistorner, Alexander; Petzold, Axel; Schippling, Sven; Costello, Fiona; Aktaş, Orhan; Vermersch, Patrick; Oreja‐Guevara, Celia; Comı, Gıancarlo; Leocani, Letizia; García‐Martín, Elena; Paul, Friedemann; Havrdová, Eva; Frohman, Elliot M.; Balcer, Laura J.; Green, Ari J.; Calabresi, Peter A.; Villoslada, Pablo

doi:10.1016/s1474-4422(16)00068-5

Cited by 268 publications

(246 citation statements)

References 36 publications

Supporting

Mentioning

221

Contrasting

Unclassified

Order By: Relevance

“…This is in contrast to OCT derived parameters, where optic neuritis causes additional damage and thus frequently interferes with the use of OCT parameters as surrogates for disease progression 24 . Recent applications of OCT as disease progression biomarker have therefore focused on eyes without previous optic neuritis 25,26 . The high frequency of optic neuritis in MS patients (confirmed in our random sample) thus limits these novel OCT applications.…”

Section: Discussionmentioning

confidence: 99%

Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density

et al. 2016

Self Cite

View full text Add to dashboard Cite

Background Many studies in multiple sclerosis (MS) have investigated the retina. Little however is known about the effect of MS on the cornea, which is innervated by the trigeminal nerve. It is the site of neural-immune interaction with local dendritic cells reacting in response- to environmental stimuli. Objective This study aims to investigate the effect of MS on- corneal nerve fibres and dendritic cells in the subbasal nerve plexus using in vivo confocal microscopy (IVCM). Methods We measured the corneal nerve fibre and dendritic cell density in 26 MS patients and matched healthy controls using a Heidelberg Retina Tomograph with Cornea Module. Disease severity was assessed with the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale, visual acuity and retinal optical coherence tomography. Results We observed significant reduction in total corneal nerve fibre density in MS patients compared to controls. Dendritic cell density was similar in both groups. Reduced total nerve fibre density was associated with worse clinical severity, but not with previous clinical trigeminal symptoms, retinal neuroaxonal damage, visual acuity, or disease duration. Conclusion Corneal nerve fibre density is a promising new imaging marker for the assessment of disease severity in MS and should be investigated further.

show abstract

Section: Discussionmentioning

confidence: 99%

Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…The introduction in the last few decades of OCT in the study of MS has provided new information on correlations between visual deficiencies and retinal alterations in these patients and also between pRNFL thinning and disability [9]. Recent studies using OCT showed that low contrast letter acuity scores in MS patients reflect the axonal and neuronal losses in the anterior visual pathway (observed as RNFL and retinal neuronal layer thinning quantified using OCT technology) [20, 21].…”

Section: Multiple Sclerosismentioning

confidence: 99%

“…Recent research using OCT technology has demonstrated that parameters provided by OCT are accurate to detect various inner retinal or optic nerve pathologies. In the last decade this technique has also been applied in several areas in neurology, demonstrating its potential role as a fundamental tool in the study of neurodegenerative diseases, such as MS, PD, or AD [3–9]. At the present time, however, no clear guidelines are available on whether one, several, or all of the retinal parameters measured by OCT can be used in the diagnosis of these pathologies, and therefore the use of OCT technology in the clinical management of neurological patients is limited to follow disease progression in several common pathologies.…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography as a Biomarker for Diagnosis, Progression, and Prognosis of Neurodegenerative Diseases

Satué

Obís

Rodrigo

et al. 2016

Journal of Ophthalmology

Self Cite

View full text Add to dashboard Cite

Neurodegenerative diseases present a current challenge for accurate diagnosis and for providing precise prognostic information. Developing imaging biomarkers for multiple sclerosis (MS), Parkinson disease (PD), and Alzheimer's disease (AD) will improve the clinical management of these patients and may be useful for monitoring treatment effectiveness. Recent research using optical coherence tomography (OCT) has demonstrated that parameters provided by this technology may be used as potential biomarkers for MS, PD, and AD. Retinal thinning has been observed in these patients and new segmentation software for the analysis of the different retinal layers may provide accurate information on disease progression and prognosis. In this review we analyze the application of retinal evaluation using OCT technology to provide better understanding of the possible role of the retinal layers thickness as biomarker for the detection of these neurodegenerative pathologies. Current OCT analysis of the retinal nerve fiber layer and, specially, the ganglion cell layer thickness may be considered as a good biomarker for disease diagnosis, severity, and progression.

show abstract

“…Expert consensus of the MAGNIMS network proposed the inclusion of optic nerve lesions in the imaging criteria for the spatial dissemination of the revised McDonald’s criteria 1. Clinical evidence of optic neuritis confirmed by ophthalmological evaluation, MRI, optical coherence tomography (OCT) measure of retinal nerve fibre layer (RNFL) thinning9 or VEPs hastens diagnosis (figure 2B). A cross-sectional study including 65 patients with MS, clinically isolated syndrome (CIS) and neuromyelitis optical spectrum disorder demonstrated that VEPs were superior to OCT for detecting mild and moderate forms of optic neuritis (68% and 27%, respectively) as well as changes in the presumably unaffected eye (86% and 14%, respectively) 3.…”

Section: Visual Evoked Potentialsmentioning

confidence: 99%

“…The reason why VEP incongruities are observed in the asymptomatic eye remains debated. Three main hypotheses have been discussed in the literature: (1) VEPs are able to detect subclinical abnormalities of the optic nerve due to previous injury or (2) due to retrograde axonal degeneration9 or (3) its latency delay results from a visual compensation in the attempt to coordinate information arriving to the occipital cortex 10…”

Section: Visual Evoked Potentialsmentioning

confidence: 99%

Clinical evoked potentials in neurology: a review of techniques and indications

Lascano

Lalive

Hardmeier

et al. 2017

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

Evoked potentials (EPs) are a powerful and cost-effective tool for evaluating the integrity and function of the central nervous system. Although imaging techniques, such as MRI, have recently become increasingly important in the diagnosis of neurological diseases, over the past 30 years, many neurologists have continued to employ EPs in specific clinical applications. This review presents an overview of the recent evolution of 'classical' clinical applications of EPs in terms of early diagnosis and disease monitoring and is an extension of a previous review published in this journal in 2005 by Walsh and collaborators. We also provide an update on emerging EPs based on gustatory, olfactory and pain stimulation that may be used as clinically relevant markers of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and cortical or peripheral impaired pain perception. EPs based on multichannel electroencephalography recordings, known as high-density EPs, help to better differentiate between healthy subjects and patients and, moreover, they provide valuable spatial information regarding the site of the lesion. EPs are reliable disease-progression biomarkers of several neurological diseases, such as multiple sclerosis and other demyelinating disorders. Overall, EPs are excellent neurophysiological tools that will expand standard clinical practice in modern neurology.

show abstract

Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

Abstract: Background: Most of Multiple Sclerosis (MS) patients without previous optic neuritis (ON) show

Cited by 268 publications

References 36 publications

Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density

Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density

Optical Coherence Tomography as a Biomarker for Diagnosis, Progression, and Prognosis of Neurodegenerative Diseases

Clinical evoked potentials in neurology: a review of techniques and indications

Contact Info

Product

Resources

About