Retinal Nerve Fiber Layer and Peripapillary Choroidal Thicknesses in Non-Glaucomatous Unilateral Optic Atrophy Compared with Unilateral Advanced Pseudoexfoliative Glaucoma

Küçükevcilioğlu, Murat; Ayyıldız, Önder; Aykas, Seckin; Gökçe, Gökçen; Koylu, Mehmet Talay; Özgönül, Cem; Özge, Gökhan; Mumcuoğlu, Tarkan; Yumuşak, Erhan

doi:10.3109/02713683.2016.1170856

Cited by 3 publications

(4 citation statements)

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“…In this study, significant differences in peripapillary RNFL thicknesses were observed between eyes with optic atrophy and control eyes, but not in macular choroidal thickness. One previous study has reported that peripapillary choroidal thickness in patients with non-glaucomatous optic atrophy caused by ON is thinner than that in controls globally and at temporal, temporal-superior, and nasal-inferior regions[ 12 ]. In our study, there was no significant difference in macular choroidal thickness between patients with optic atrophy and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…One study has reported that peripapillary RNFL thinning in non-glaucomatous optic atrophy is associated with peripapillary choroidal thinnin[ 12 ]. However, no study has reported the association between macular choroidal thickness and peripapillary RNFL thickness in patients with non-glaucomatous optic atrophy or in normal adults up to date.…”

Section: Discussionmentioning

confidence: 99%

“…Peripapillary retinal nerve fiber layer analysis has become one of the most useful tools for evaluating optic nerve damage in optic neuropathies. Recently, in addition to measurement of nerve fiber layer thickness, choroidal thickness has been investigated in various optic neuropathies including glaucoma, anterior ischemic optic neuropathy, and optic neuritis (ON)[ 4 – 12 ]. Several studies have reported that peripapillary choroidal thickness is thinner in glaucomatous eyes compared to that in normal eyes[ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Peripapillary and macular choroidal thicknesses are also related to anterior ischemic optic neuropathy[ 8 – 11 ]. One study has reported that peripapillary RNFL thinning in non-glaucomatous optic atrophy is associated with peripapillary choroidal thinning[ 12 ]. Another population-based study on 478 non-glaucomatous adults has revealed that thinner peripapillary choroidal thickness is associated with thinner peripapillary RNFL thickness[ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Macular choroidal thickness and peripapillary retinal nerve fiber layer thickness in normal adults and patients with optic atrophy due to acute idiopathic demyelinating optic neuritis

Park

Choi

2018

PLoS ONE

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PurposeTo evaluate the association between macular choroidal thickness and peripapillary RNFL thickness in patients with optic atrophy due to acute idiopathic demyelinating optic neuritis and in normal controls using spectral domain optical coherence tomography (SD-OCT).MethodsWe performed SD-OCT peripapillary RNFL circular scan centered on the optic disc with horizontal and vertical crosshair scans through the fovea using the enhanced depth technique in 62 eyes with optic atrophy due to acute idiopathic demyelinating optic neuritis and 86 eyes of normal controls. The association between RNFL thickness and macular choroidal thickness measurements was assessed.ResultsThe mean age was 43 ± 14 years (mean ± SD) in patients with optic atrophy and 45 ± 16 years in healthy controls (p = 0.791). There was a significant association between nasal peripapillary RNFL thickness and choroidal thickness at 3.0 mm nasal to the foveal center in patients with optic atrophy in multivariate analysis (estimate = 1.398, p = 0.011). In controls, there were significant associations between global average, superior, and inferior peripapillary RNFL thickness and choroidal thickness at 3.0 mm superior to the foveal center (estimate = -60.112, p = 0.044, estimate = 15.821, p = 7.312, and estimate = 15.203, p = 7.222, respectively).ConclusionsOur SD-OCT data revealed that there was a significant association between peripapillary RNFL thickness and macular choroidal thickness in patients with optic atrophy due to acute idiopathic demyelinating optic neuritis and in controls, although the mechanism remained unclear. The difference in the pattern of association between patients with optic atrophy and controls suggests that optic atrophy caused by acute idiopathic demyelinating optic neuritis could affect the pattern of association between peripapillary RNFL thickness and macular choroidal thickness.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%