Retinal microvasculature and vasoreactivity changes in hypertension using optical coherence tomography-angiography

Zeng, Rebecca; Garg, Itika; Bannai, Deepthi; Kasetty, Megan; Katz, Raviv; Park, Jea Young; Lizano, Paulo; Miller, John B.

doi:10.1007/s00417-022-05706-6

Cited by 9 publications

(6 citation statements)

References 47 publications

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“…22 Conversely, other investigations with SD-OCTA were able to demonstrate a diminution of VD in SCP in patients with HTN. 26,27 We explained this difference because of the presence of comorbidities that could affect the autoregulatory capacity of SCP in the first study, and by the small sample size of the last one.…”

Section: Discussionmentioning

confidence: 99%

Swept-source optical coherence tomography angiography automatic analysis of microvascular changes secondary to systemic hypertension

Sargues

Adsuara

Navarro

et al. 2022

European Journal of Ophthalmology

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Introduction The aim of our study is to report swept-source optical coherence tomography angiography (SS-OCTA) quantitative parameters of retinal and choroidal microvasculature in patients with systemic hypertension (HTN) using a built-in software of SS-OCTA. Methods We performed a retrospective study. This study enrolled 93 eyes of 51 subjects with HTN and 71 eyes of 38 healthy subjects. OCTA quantitative parameters (vessel density (VD) and foveal avascular zone (FAZ) area of superficial capillary plexus (SCP), middle capillary plexus (MCP), deep capillary plexus (DCP), total capillary plexus (TCP) and choriocapillaris (CC)) of the OCTA cube of 4,5 mm × 4,5 mm were recorded. Results A decrease of parafoveal VD in CC, DCP and TCP were demonstrated between HTN group and control group ( p < 0,05). Conversely, no differences were demonstrated in parafoveal VD of SCP and MCP ( p > 0,05). Subgroup analysis revealed a diminution of central VD at SCP, DCP and TCP in patients taking one antihypertensive drug compared to patients treated with two medications ( p < 0,05). Correlation analysis showed a significant, albeit weak, negative correlation between HTN duration, and parafoveal VD in the SCP and FAZ area at SCP, DCP and TCP ( p < 0,05 and r < 0,300). Conclusion When normative data are available, OCTA might be used as a potential tool in the prevention and follow-up of end-organ damage secondary to HTN. Nonetheless, further studies are needed to confirm this hypothesis.

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Section: Discussionmentioning

confidence: 99%

Swept-source optical coherence tomography angiography automatic analysis of microvascular changes secondary to systemic hypertension

Sargues

Adsuara

Navarro

et al. 2022

European Journal of Ophthalmology

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“…Retinal vessel density, decrease in retinal and choroidal thicknesses are indicators of coronary artery disease [ 27 ]. On the other hand, a significant decrease in retinal VD has also been demonstrated in patients with hypertension [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Retinal Vascular Density Change in Patients With Aortic Valve Regurgitation

Topaloğlu

Bılgın

2023

Cardiol Res

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Background The aim of this study was to assess retinal vessel density in the superficial capillary plexus layer, deep capillary plexus layer and choriocapillaris plexus layer in patients with aortic valve regurgitation (AR) using optical coherence tomography angiography (OCTA). Methods Thirty-eight healthy participants (group 1) and 38 patients with AR (group 2) were assessed for this study. Diagnosis of AR is made by transthoracic echocardiography (TTE). Severity of AR was assessed according to values in the 2014 American Heart Association/American College of Cardiology (AHA/ACC) valve guideline. Superficial capillary plexus density (SCPD), deep capillary plexus density (DCPD) and choriocapillaris plexus density (CCPD) were analyzed between groups using OCTA. Results SCPD measurements were found to be decreased in the nasal, inferior and central regions of patients with AR (P ≤ 0.05). DCPD measurements were found to be decreased in the nasal and inferior regions of patients with AR (P ≤ 0.05). CCPD measurements were found to be decreased in the inferior and central regions of patients with AR (P ≤ 0.05). In patients with AR, CCPD measurements were significantly decreased in the inferior region compared to the control group. Central macular thickness was found to be significantly decreased in the patients with AR. Conclusions Patients with AR showed decreased flow density compared with healthy controls. Retinal perfusion measured using OCTA in patients with AR may give an idea about microperfusion.

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Section: Systemic Arterial Hypertensionmentioning

confidence: 99%

“…Recent studies have used OCTA to investigate retinal vascularity in patients with systemic hypertension, finding a significant reduction in VD in hypertensive patients [17,18]. As seen in Table 1, multiple studies demonstrate a decrease in VD in both the deep and superficial vascular plexi [13,[17][18][19][20][21][22][23][24][25][26][27]. As shown in Table 1, different studies reported the VD values of both the parafoveal region alone and the entire macular region analyzed, with VD values averaged as a mean.…”

Section: Systemic Arterial Hypertensionmentioning

confidence: 99%

The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease

Kellner,

Harris,

Ciulla

et al. 2024

JCM

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Alterations in microvasculature represent some of the earliest pathological processes across a wide variety of human diseases. In many organs, however, inaccessibility and difficulty in directly imaging tissues prevent the assessment of microvascular changes, thereby significantly limiting their translation into improved patient care. The eye provides a unique solution by allowing for the non-invasive and direct visualization and quantification of many aspects of the human microvasculature, including biomarkers for structure, function, hemodynamics, and metabolism. Optical coherence tomography angiography (OCTA) studies have specifically identified reduced capillary densities at the level of the retina in several eye diseases including glaucoma. This narrative review examines the published data related to OCTA-assessed microvasculature biomarkers and major systemic cardiovascular disease. While loss of capillaries is being established in various ocular disease, pilot data suggest that changes in the retinal microvasculature, especially within the macula, may also reflect small vessel damage occurring in other organs resulting from cardiovascular disease. Current evidence suggests retinal microvascular biomarkers as potential indicators of major systemic cardiovascular diseases, including systemic arterial hypertension, atherosclerotic disease, and congestive heart failure.

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Retinal microvasculature and vasoreactivity changes in hypertension using optical coherence tomography-angiography

Cited by 9 publications

References 47 publications

Swept-source optical coherence tomography angiography automatic analysis of microvascular changes secondary to systemic hypertension

Swept-source optical coherence tomography angiography automatic analysis of microvascular changes secondary to systemic hypertension

Retinal Vascular Density Change in Patients With Aortic Valve Regurgitation

The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease

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