Swept-source optical coherence tomography angiography automatic analysis of microvascular changes secondary to systemic hypertension

Sargues, Lidia Remolí; Adsuara, Clara Monferrer; Navarro, V. Castro; Palop, Catalina Navarro; Hernández, Juan Antonio Rodríguez; Taulet, Enrique Cervera

doi:10.1177/11206721221146674

Cited by 4 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Parafoveal VD in the choriocapillaris, DCP, and total capillary plexus was also found to be decreased in hypertensive patients versus those of controls [22]. Conversely, no significant difference was found in the SCP and middle capillary plexus between hypertensive and control patients [22]. Similar results were obtained in another study in which there was a significant decrease in VD between hypertensive and control eyes in the DRL, but no significant difference in the VD of the SRL [23].…”

Section: Systemic Arterial Hypertensionsupporting

confidence: 82%

“…Bridging this concept, Donati et al [21] showed a significant reduction in the VD of the DRL and an enlargement of the deep FAZ area in hypertensive patients, thus suggesting the presence of an early modification of the microvascular network at the level of the deep retinal plexus [21]. Parafoveal VD in the choriocapillaris, DCP, and total capillary plexus was also found to be decreased in hypertensive patients versus those of controls [22]. Conversely, no significant difference was found in the SCP and middle capillary plexus between hypertensive and control patients [22].…”

Section: Systemic Arterial Hypertensionmentioning

confidence: 94%

“…Recent studies have used OCTA to investigate retinal vascularity in patients with systemic hypertension, finding a significant reduction in VD in hypertensive patients [17,18]. As seen in Table 1, multiple studies demonstrate a decrease in VD in both the deep and superficial vascular plexi [13,[17][18][19][20][21][22][23][24][25][26][27]. As shown in Table 1, different studies reported the VD values of both the parafoveal region alone and the entire macular region analyzed, with VD values averaged as a mean.…”

Section: Systemic Arterial Hypertensionmentioning

confidence: 99%

See 2 more Smart Citations

The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease

Kellner,

Harris,

Ciulla

et al. 2024

JCM

View full text Add to dashboard Cite

Alterations in microvasculature represent some of the earliest pathological processes across a wide variety of human diseases. In many organs, however, inaccessibility and difficulty in directly imaging tissues prevent the assessment of microvascular changes, thereby significantly limiting their translation into improved patient care. The eye provides a unique solution by allowing for the non-invasive and direct visualization and quantification of many aspects of the human microvasculature, including biomarkers for structure, function, hemodynamics, and metabolism. Optical coherence tomography angiography (OCTA) studies have specifically identified reduced capillary densities at the level of the retina in several eye diseases including glaucoma. This narrative review examines the published data related to OCTA-assessed microvasculature biomarkers and major systemic cardiovascular disease. While loss of capillaries is being established in various ocular disease, pilot data suggest that changes in the retinal microvasculature, especially within the macula, may also reflect small vessel damage occurring in other organs resulting from cardiovascular disease. Current evidence suggests retinal microvascular biomarkers as potential indicators of major systemic cardiovascular diseases, including systemic arterial hypertension, atherosclerotic disease, and congestive heart failure.

show abstract

Section: Systemic Arterial Hypertensionsupporting

confidence: 82%