Retinal microcirculation in association with caffeinated and alcoholic drinks in subjects at increased cardiovascular risk

Karatzi, Kalliopi; Aissopou, Evaggelia; Katsana, Konstantina; Moiragia, Marousa; Tentolouris, Nikolaοs; Sfikakis, Petros P.; Protogerou, Athanase D.

doi:10.1111/micc.12320

Cited by 5 publications

(10 citation statements)

References 32 publications

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“…In individuals with, versus without, a history of the cardiovascular disease, the minimum of the J-curve in the association of total alcohol consumption with the total MVD composite score was located at higher levels of total alcohol consumption, possibly because levels of background oxidative stress are higher in individuals with, versus without, a history of cardiovascular disease [ 5 , 74 ]. Biologically, higher levels of ethanol-induced oxidative stress may be required to induce more oxidative stress than already present in the background [ 5 , 27 ]. Indeed, consistent with this concept, we found that the minimum in the J-curve was located at higher levels of alcohol consumption in individuals with, versus without, a cardiovascular risk factor (for any individual risk factor under study).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, there is some evidence that alcohol consumption may be a determinant of MVD, and that the association of alcohol consumption with MVD may be J-shaped, however, this evidence has important limitations [ 15 – 53 ]. First, many population-based studies did not quantify the amount of alcohol consumption [ 15 , 18 , 21 , 27 , 28 , 32 , 33 , 37 , 40 , 44 , 47 , 50 , 52 ]; did not take potential cardiovascular [ 16 – 20 , 22 , 25 , 26 , 29 , 34 , 35 , 38 , 39 , 41 , 45 , 46 , 48 , 49 , 51 , 53 ] and/or lifestyle [ 23 , 24 , 31 , 32 , 42 , 43 ] confounders in to account; and/or did not account for sick quitters [ 19 , 22 , 30 , 34 , 36 , 42 , 43 ] (i.e. individuals who quit drinking and are thought to have an increased cardiovascular risk) [ 54 , 55 ].…”

Section: Introductionmentioning

confidence: 99%

“…individuals who quit drinking and are thought to have an increased cardiovascular risk) [ 54 , 55 ]. Second, only few studies investigated the associations of wine, beer, and spirits consumption with MVD [ 23 , 26 , 27 , 42 , 43 , 45 ]. Third, no population-based studies have yet reported the association between alcohol consumption and MVD in individuals with and without a history of cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

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Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study

Baan

Eussen

Houben

et al. 2023

Cardiovasc Diabetol

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Background Microvascular dysfunction (MVD) is an important contributor to major clinical disease such as stroke, dementia, depression, retinopathy, and chronic kidney disease. Alcohol consumption may be a determinant of MVD. Objective Main objectives were (1) to study whether alcohol consumption was associated with MVD as assessed in the brain, retina, skin, kidney and in the blood; and (2) to investigate whether associations differed by history of cardiovascular disease or sex. Design We used cross-sectional data from The Maastricht Study (N = 3,120 participants, 50.9% men, mean age 60 years, and 27.5% with type 2 diabetes [the latter oversampled by design]). We used regression analyses to study the association between total alcohol (per unit and in the categories, i.e. none, light, moderate, high) and MVD, where all measures of MVD were combined into a total MVD composite score (expressed in SD). We adjusted all associations for potential confounders; and tested for interaction by sex, and history of cardiovascular disease. Additionally we tested for interaction with glucose metabolism status. Results The association between total alcohol consumption and MVD was non-linear, i.e. J-shaped. Moderate versus light total alcohol consumption was significantly associated with less MVD, after full adjustment (beta [95% confidence interval], -0.10 [-0.19; -0.01]). The shape of the curve differed with sex (Pinteraction = 0.03), history of cardiovascular disease (Pinteraction < 0.001), and glucose metabolism status (Pinteraction = 0.02). Conclusions The present cross-sectional, population-based study found evidence that alcohol consumption may have an effect on MVD. Hence, although increasing alcohol consumption cannot be recommended as a policy, this study suggests that prevention of MVD may be possible through dietary interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study

Baan

Eussen

Houben

et al. 2023

Cardiovasc Diabetol

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“…Nevertheless, it caused a measurable change in retinal capillary perfusion, retinachoroid blood flow, and CBF in healthy participants. Compared to younger and healthier people, caffeine may elevate BP and constrict retinal vessels more effectively in older individuals and those with hypertension, diabetes, Table 3 Cerebral blood flow and retina-choroid blood flow parameters (mL/100 mL/min) before and after drinking coffee (n = 4) or water (n = 4) or retinal microvascular disorders [36,37]. Therefore, it reminds us the possible health risks after drinking a moderate dosage of coffee.…”

Section: Discussionmentioning

confidence: 99%

A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals

Zhu

Wang

et al. 2022

BMC Ophthalmol

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Aim: Caffeinated beverages are very popular across populations and cultures, but quantitative evidence of the acute effects of moderate coffee doses on retinal perfusion is sparse and contradicting. Thus, the aim of this randomized, cross-over and parallel-group design study was to investigate whether moderate consumption of coffee alters macular retinal capillary perfusion in young healthy individuals. Methods: Twenty-seven young healthy individuals were recruited for this study. Acute changes in retinal microvasculature were assessed using spectral-domain optical coherence tomography angiography (SD-OCTA) at baseline, 0.5 h, and 2 h after intake of coffee, or water. Meanwhile, cerebral blood flow (CBF) and retina-choroid blood flow were evaluated in a parallel-group design (4 participants each in coffee or water group) using magnetic resonance imaging (MRI) with pseudo-continuous arterial spin labeling sequences. Results: Two hours after coffee intake, blood caffeine concentration increased from 0 to 5.05 ± 1.36 µg/mL. Coffee caused a significant decrease in retinal vessel diameter index (VDI) (19.05 ± 0.24 versus [vs] 19.13 ± 0.26; p < 0.001) and CBF in the frontal lobe (77.47 ± 15.21 mL/100 mL/min vs. 84.13 ± 15.55 mL/100 mL/min; p < 0.05) 2 h after intake. However, it significantly increased retina-choroid blood flow after 0.5 and 2 h (163.18 ± 61.07 mL/100 mL/min vs. 132.68 ± 70.47 mL/100 mL/min, p < 0.001, and 161.21 ± 47.95 vs. 132.68 ± 70.47; p < 0.001, respectively). Conclusion: This is the first study to demonstrate the acute effects of daily dose coffee consumption on retinal capillary perfusion using SD-OCTA combinate with blood flow MRI. The findings imply that although moderate coffee intake caused a significant increase in retina-choroid blood flow, there was a significant acute decrease both in macular retinal capillary perfusion and CBF.

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“…A posteriori DPs are based on statistical methods and can incorporate actual characteristics of individuals' choices in relation to the development of a disease (18) and they provide new insight on the relationship between diet and disease. Limited data are available on the association between a posteriori defined DPs and the early dysfunction of the microcirculation which is a common pathophysiological mechanism in the development of insulin resistance, CVD and type 2 diabetes mellitus (19,20) .…”

mentioning

confidence: 99%

Associations of dietary patterns with blood pressure and markers of subclinical arterial damage in adults with risk factors for CVD

Tzelefa

Tsirimiagkou

Argyris

et al. 2021

Public Health Nutr.

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Objective: Unhealthy diet is a modifiable risk factors leading to subclinical arterial damage (SAD), high BP and CVD. It was aimed to investigate the possible associations of dietary patterns (DPs) with SAD in adults having multiple CVD risk factors. Design: Dietary intake was evaluated through two 24-h dietary recalls and principal component analysis was used to identify DPs. Oscillometry, applanation tonometry with pulse wave analysis and carotid ultrasound were used to assess peripheral and aortic BP, arterial stiffness and pressure wave reflections. Setting: Laiko University Hospital, Athens, Greece Participants: 470 individuals (53.1±14.2 years) with CVD risk factors were enrolled. Results: A pattern characterized by increased consumption of whole-grain cereals, white meat and reduced consumption of sugar was positively associated with common carotid compliance (β=0.01, 95%CI 0.00 – 0.01, whereas a pattern high in refined cereals, red and processed meat was positively associated with brachial but not aortic systolic pressure (β=1.76, 95%CI 0.11 – 3.42) and mean arterial pressure (MAP) (β=1.18, 95%CI=0.02 −2.38). Low consumption of low-fat dairy products, high consumption of full fat cheese and butter was positively associated with MAP (β=0.97,95%CI=0.01 – 1.95). Increased consumption of vegetables, fruits, fresh juices, fish and seafood was inversely associated with augmentation index (AIx) (β=−1.01,95% CI=−1.93 – 0.09). Conclusion: Consumption of whole grains, white meat, fruits/vegetables, fish/seafood, and avoidance of sugar was associated with improved SAD. Preference in refined grains, red/processed meat, high fat cheese/butter and low intake of low-fat dairy products was associated with BP elevation. Future studies are needed to confirm the present findings.

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Retinal microcirculation in association with caffeinated and alcoholic drinks in subjects at increased cardiovascular risk

Abstract: Alcohol and alcoholic drinks' consumption were not associated, while decaffeinated coffee and caffeine consumption were associated in an opposing pattern with retinal vessel calibers. The reason of this controversy merits further investigation.

Cited by 5 publications

References 32 publications

Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study

Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study

A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals

Associations of dietary patterns with blood pressure and markers of subclinical arterial damage in adults with risk factors for CVD

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