A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals

Zhu, Xiaofeng; Zhu, Jiong; Wang, Yong-Yi; Chu, Zhongdi; Wang, Ke; Xu, Yi; Lu, Lina; Zou, Haidong

doi:10.1186/s12886-022-02638-x

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…ASL is used to evaluate the tissue perfusion rate. Tissue perfusion—the exchange of water and nutrients with tissues—occurs over the entire length of capillaries (Zhu et al, 2022 ). ASL basically “tracks” the water molecules in the blood from the arterial cavity to the tissue capillary bed and treats the water molecules as a freely diffusible tracer.…”

Section: Discussionmentioning

confidence: 99%

Blood flow perfusion in visual pathway detected by arterial spin labeling magnetic resonance imaging for differential diagnosis of ocular ischemic syndrome

Chen

Xue²,

Huang³

et al. 2023

Front. Neurosci.

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BackgroundOcular ischemic syndrome (OIS), attributable to chronic hypoperfusion caused by marked carotid stenosis, is one of the important factors that cause ocular neurodegenerative diseases such as optic atrophy. The current study aimed to detect blood flow perfusion in a visual pathway by arterial spin labeling (ASL) and magnetic resonance imaging (MRI) for the differential diagnosis of OIS.MethodsThis diagnostic, cross-sectional study at a single institution was performed to detect blood flow perfusion in a visual pathway based on 3D pseudocontinuous ASL (3D-pCASL) using 3.0T MRI. A total of 91 participants (91 eyes) consisting of 30 eyes with OIS and 61 eyes with noncarotid artery stenosis-related retinal vascular diseases (39 eyes with diabetic retinopathy and 22 eyes with high myopic retinopathy) were consecutively included. Blood flow perfusion values in visual pathways derived from regions of interest in ASL images, including the retinal-choroidal complex, the intraorbital segments of the optic nerve, the tractus optics, and the visual center, were obtained and compared with arm-retinal circulation time and retinal circulation time derived from fundus fluorescein angiography (FFA). Receiver operating characteristic (ROC) curve analyses and the intraclass correlation coefficient (ICC) were performed to evaluate the accuracy and consistency.ResultsPatients with OIS had the lowest blood flow perfusion values in the visual pathway (all p < 0.05). The relative intraorbital segments of optic nerve blood flow values at post-labeling delays (PLDs) of 1.5 s (area under the curve, AUC = 0.832) and the relative retinal–choroidal complex blood flow values at PLDs of 2.5 s (AUC = 0.805) were effective for the differential diagnosis of OIS. The ICC of the blood flow values derived from the retinal–choroidal complex and the intraorbital segments of the optic nerve between the two observers showed satisfactory concordance (all ICC > 0.932, p < 0.001). The adverse reaction rates of ASL and FFA were 2.20 and 3.30%, respectively.Conclusion3D-pCASL showed that the participants with OIS had lower blood flow perfusion values in the visual pathway, which presented satisfactory accuracy, reproducibility, and safety. It is a noninvasive and comprehensive differential diagnostic tool to assess blood flow perfusion in a visual pathway for the differential diagnosis of OIS.

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Section: Discussionmentioning

confidence: 99%

Blood flow perfusion in visual pathway detected by arterial spin labeling magnetic resonance imaging for differential diagnosis of ocular ischemic syndrome

Chen

Xue²,

Huang³

et al. 2023

Front. Neurosci.

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“…Prolonged uncontrolled hyperglycemia could cause severe ocular microvascular abnormalities and loss of the blood-retinal barrier 54 . Randomized controlled trials have demonstrated that daily dose coffee consumption leads to acute reductions in macular retinal capillary perfusion and cerebral circulation 55 , and that caffeine intake could induce microvascular constriction in ophthalmology 56 . In addition, coffee could affect the development of diabetic ocular complications through changes in intraocular structures such as intraocular pressure.…”

Section: Discussionmentioning

confidence: 99%

Association between coffee consumption and diabetic complications: A two- sample Mendelian randomization study

Liang,

Hu,

Jia

et al. 2023

Preprint

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In response to the current clinical debate regarding the causal relationship between coffee consumption and the risk of diabetic complications, we conducted a two-sample Mendelian randomization study to determine the impact of coffee on diabetic complications, and further explored this association in complications of diabetes subtypes. We collected summary statistics from 22 genome-wide association studies in the UK Biobank database and FinnGen R9 repository. Causal effects were assessed using the inverse variance weighted (IVW) method, MR pleiotropy residual sum and outlier (MR-PRESSO) model, maximum likelihood method, weighted median method, simple median method, and MR-Egger method. Cochran's Q test, MR-Egger intercept test, and MR-PRESSO global test were utilized for sensitivity analysis. Genetic evidence indicates a positive linkage between coffee intake and the risk of diabetes complications, with coffee significantly increasing the risk of diabetic nephropathy, diabetic neuropathy, and diabetic peripheral angiopathy, and possibly promoting the occurrence and progression of diabetic ocular complications. Coffee also contributed substantially to the complications of type 2 diabetes, while the connection between coffee consumption and complications of type 1 diabetes was modestly notable. These findings provide a scientific foundation for more targeted prevention and management of diabetes complications.

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A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals

Cited by 2 publications

References 39 publications

Blood flow perfusion in visual pathway detected by arterial spin labeling magnetic resonance imaging for differential diagnosis of ocular ischemic syndrome

Blood flow perfusion in visual pathway detected by arterial spin labeling magnetic resonance imaging for differential diagnosis of ocular ischemic syndrome

Association between coffee consumption and diabetic complications: A two- sample Mendelian randomization study

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