Retinal Infiltrates in Six Patients With an Associated Viral Syndrome

Goldstein, Burton G.; Pavan, Peter R.

doi:10.1097/00006982-198500530-00002

Cited by 14 publications

(8 citation statements)

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“…Flu-like illness occurred in 85.7% of the patients in our study, 1 to 3 weeks prior to the onset of visual symptoms. Such manifestations have been previously reported in one half to all patients with AMR [ 1 – 6 ]. Results of our study, consistent with previous data, show that retinal infiltrates tended to be bilateral, scattered in the posterior pole and/or the retinal periphery.…”

Section: Discussionmentioning

confidence: 61%

“…Lesion size ranged from 150 to 1500 μm. Small lesions appeared to involve the inner retinal layers, and large lesions seemed to involve all retinal layers [ 1 – 6 ]. The retinal pigment epithelium tended to be spared on OCT in most affected eyes [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Acute multifocal retinitis (AMR), usually preceded by a flu-like illness, is a rare condition usually affecting otherwise healthy adults, characterized by the occurrence of multiple small or mid-sized superficial retinal infiltrates. These lesions have typically a self-limited course with patients regaining a normal visual acuity [ 1 – 3 ]. AMR was first described by Goldstein and Pavan in ten eyes of six patients in 1985 [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…These lesions have typically a self-limited course with patients regaining a normal visual acuity [ 1 – 3 ]. AMR was first described by Goldstein and Pavan in ten eyes of six patients in 1985 [ 1 ]. Since then, a few cases have been reported [ 2 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Acute multifocal retinitis: a retrospective review of 35 cases

Khochtali

Gargouri

Zina

et al. 2018

J Ophthal Inflamm Infect

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BackgroundAcute multifocal retinitis is a rare condition that has been considered to be often idiopathic. The purpose of this study was to analyze clinical features and causes of acute multifocal retinitis.ResultsThis study is a retrospective review of the charts of 35 patients with acute multifocal retinitis. Patients with three or more retinal lesions in at least one eye, with at least one lesion of less than 500 μm in size were included. All patients had complete ophthalmological examination, fundus photography, and fluorescein angiography. Twelve patients (34.3%) had optical coherence tomography. An extensive work-up was performed including a detailed comprehensive medical history, examination by an internist and an infectious disease specialist, a chest X-ray, Mantoux test, and laboratory tests for syphilis, human immunodeficiency virus, Bartonella, and Rickettsia. Of the 35 patients, 25 (71.4%) had bilateral involvement and 10 (28.6%) had unilateral involvement (total number of eyes: 60). Mean best-corrected visual acuity (BCVA) was 20/25 (range, 20/1000–20/20). Retinal lesions ranged from 3 to more than 20 in number in at least 1 eye, and from 150 to 1500 μm in size. Associated findings included mild anterior chamber inflammation in 5 eyes (8.3%), mild vitritis in 46 eyes (76.7%), optic disc swelling in 9 eyes (15%), macular star in 4 eyes (6.7%), exudative retinal detachment in 6 eyes (10%), and branch retinal artery occlusion in 6 eyes (10%). Acute multifocal retinitis was found to be caused by Rickettsia conorii infection in 20 patients (57.1%), Rickettsia typhi infection in 4 patients (11.4%), cat-scratch disease in 8 patients (22.9%), and syphilis in 1 patient (2.9%). It was idiopathic in two patients (5.7%). Retinal lesions resolved without scarring in 3 to 12 weeks in all but three eyes (5%), in which residual retinal pigment epithelial changes were noted.ConclusionRickettsial disease was the most common cause of acute multifocal retinitis. Other identified causes included cat-scratch disease and syphilis, and a very small subset of patients was diagnosed with idiopathic multifocal retinitis.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acute multifocal retinitis: a retrospective review of 35 cases

Khochtali

Gargouri

Zina

et al. 2018

J Ophthal Inflamm Infect

View full text Add to dashboard Cite

show abstract

“…Clinical reports have d e s c r i b e d retinal infiltrates associated with unclear viral infections in h u m a n s [12,22]. In most cases these lesions were self-limited and resolved within weeks without treatment.…”

Section: Introductionmentioning

confidence: 99%