Retinal ganglion cell interactions shape the developing mammalian visual system

D'Souza, Shane P; Lang, Richard A.

doi:10.1242/dev.196535

Cited by 32 publications

(23 citation statements)

References 163 publications

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“…It must be noted that the opening of the eyes in rodents does not mean full functional maturity of the retina. In rabbits and rats, amplitudes of the retinal light responses measured by electroretinography continuously increase in the first month after birth and reach the adult level between P30 and P40 [56] (Fig. 1).…”

Section: Retina Development: Similarities and Differences Between Humans And Laboratory Animalsmentioning

confidence: 97%

Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

Telegina

Kozhevnikova

Antonenko³

et al. 2021

Preprint

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Age-related macular degeneration (AMD) is a complex, multifactorial neurodegenerative disease that constitutes the most common cause of irreversible blindness in the elderly in developed countries. Incomplete knowledge about its pathogenesis prevents the search for effective methods of prevention and treatment of AMD, primarily its “dry” type, which is by far the most common (90% of all AMD cases). In recent years, AMD became younger: late stages of the disease are now detected in relatively young people. It is known that AMD pathogenesis—according to the age-related structural and functional changes in the retina—is linked with inflammation, hypoxia, oxidative stress, mitochondrial dysfunction, and an impairment of neurotrophic support, but the mechanisms that trigger the conversion of normal age-related changes to the pathological process as well as the reason for early AMD development remain unclear. In the adult mammalian retina, de novo neurogenesis is very limited. Therefore, the structural and functional features that arise during its maturation and formation can exert long-term effects on further ontogenesis of this tissue. The aim of this review is to discuss possible contributions of the changes/disturbances in retinal neurogenesis to the early development of AMD.

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Section: Retina Development: Similarities and Differences Between Humans And Laboratory Animalsmentioning

confidence: 97%

Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

Telegina

Kozhevnikova

Antonenko³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…It must be noted that the opening of the eyes in rodents does not mean full functional maturity of the retina. In rabbits and rats, amplitudes of retinal light responses measured by electroretinography continuously increase in the first month after birth and reach the adult level between P30 and P40 [ 56 ] ( Figure 1 ).…”

Section: Retina Development: Similarities and Differences Between Humans And Laboratory Animalsmentioning

confidence: 99%

Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

Telegina

Kozhevnikova

Antonenko

et al. 2021

IJMS

View full text Add to dashboard Cite

Age-related macular degeneration (AMD) is a complex multifactorial neurodegenerative disease that constitutes the most common cause of irreversible blindness in the elderly in the developed countries. Incomplete knowledge about its pathogenesis prevents the search for effective methods of prevention and treatment of AMD, primarily of its “dry” type which is by far the most common (90% of all AMD cases). In the recent years, AMD has become “younger”: late stages of the disease are now detected in relatively young people. It is known that AMD pathogenesis—according to the age-related structural and functional changes in the retina—is linked with inflammation, hypoxia, oxidative stress, mitochondrial dysfunction, and an impairment of neurotrophic support, but the mechanisms that trigger the conversion of normal age-related changes to the pathological process as well as the reason for early AMD development remain unclear. In the adult mammalian retina, de novo neurogenesis is very limited. Therefore, the structural and functional features that arise during its maturation and formation can exert long-term effects on further ontogenesis of this tissue. The aim of this review was to discuss possible contributions of the changes/disturbances in retinal neurogenesis to the early development of AMD.

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“…Given that the development of RGCs with different preferred directions is under tight genetic control 41 , these findings imply that sensory activity is able to reprogram cellular fates. In addition to imposing patterns of activity on their postsynaptic targets, RGCs secrete mitogens, such as Sonic Hedgehog, and other factors, which could regulate proliferation, commitment, migration and differentiation of downstream neurons and glia 7,8 .…”

Section: Introductionmentioning

confidence: 99%

“…

The brain is assembled during development by both innate and experience-dependent mechanisms [1][2][3][4][5][6][7] , but the relative contribution of these factors is poorly understood. Axons of retinal ganglion cells (RGCs) connect the eye to the brain, forming a bottleneck for the transmission of visual information to central visual areas.

…”

mentioning

confidence: 99%

Retinal input influences pace of neurogenesis but not cell-type configuration of the visual forebrain

Sherman

Kawakami

Baier

2021

Preprint

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SummaryThe brain is assembled during development by both innate and experience-dependent mechanisms1–7, but the relative contribution of these factors is poorly understood. Axons of retinal ganglion cells (RGCs) connect the eye to the brain, forming a bottleneck for the transmission of visual information to central visual areas. RGCs secrete molecules from their axons that control proliferation, differentiation and migration of downstream components7–9. Spontaneously generated waves of retinal activity, but also intense visual stimulation, can entrain responses of RGCs10 and central neurons11–16. Here we asked how the cellular composition of central targets is altered in a vertebrate brain that is depleted of retinal input throughout development. For this, we first established a molecular catalog17 and gene expression atlas18 of neuronal subpopulations in the retinorecipient areas of larval zebrafish. We then searched for changes in lakritz (atoh7-) mutants, in which RGCs do not form19. Although individual forebrain-expressed genes are dysregulated in lakritz mutants, the complete set of 77 putative neuronal cell types in thalamus, pretectum and tectum are present. While neurogenesis and differentiation trajectories are overall unaltered, a greater proportion of cells remain in an uncommitted progenitor stage in the mutant. Optogenetic stimulation of a pretectal area20,21 evokes a visual behavior in blind mutants indistinguishable from wildtype. Our analysis shows that, in this vertebrate visual system, neurons are produced more slowly, but specified and wired up in a proper configuration in the absence of any retinal signals.

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Retinal ganglion cell interactions shape the developing mammalian visual system

Cited by 32 publications

References 163 publications

Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

Retinal input influences pace of neurogenesis but not cell-type configuration of the visual forebrain

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