Retinal dysfunction in central serous retinopathy

Chuang, Elaine L.; Sharp, Dianne; Fitzke, F.W.; Kemp, Colin M.; Holden, A.L.; Bird, Alan C.

doi:10.1038/eye.1987.18

Cited by 65 publications

(33 citation statements)

References 10 publications

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“…These results reflect the wide range of visual and functional difficulties that have been found in serous detachments. [2][3] These functional defects have generally been attributed to retinal separation, which affects the transport of nutrients and visual pigments and also may allow some disruption of photoreceptor orientation. 7 However, evidence is increasing that in CSC pathologic changes occur over a larger area than the detachment itself, in which case some of the functional abnormalities may originate from underlying choroidal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…Even when VA is reasonably good there is compromise of functions such as contrast sensitivity, colour discrimination, dark adaptation, focal electroretinography (ERG), and microperimetry. [2][3][4][5][6] This study was undertaken to examine the function of the macula in patients with unilateral resolved CSC. Microperimetry, a technique for accurately testing macular sensitivity and retinal fixation, with strict correspondence of visual parameters and macular morphology, was used for the examination of macular function.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy

Özdemir

Karacorlu

Şentürk

et al. 2006

Eye

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Purpose To determine macular sensitivity and fixation characteristics in patients with unilateral resolved central serous chorioretinopathy (CSC) using fundus-related microperimetry. Methods We reviewed 15 eyes with resolved CSC and 15 normal healthy eyes that had undergone fundus-related microperimetry. The macular sensitivity was measured using the recently introduced fundus-related microperimeter, MP-1. The best-corrected visual acuity (VA) (BCVA), mean retinal sensitivity in the central 101 (central microperimetry, cMP-1) and in the paracentral 10-201 (paracentral microperimetry, pMP-1), and fixation stability and location were determined and compared with measurements in control eyes. Results BCVA at the time of this study was 20/20 in all the affected eyes, and fundus examination and optical coherence tomography findings revealed no serous detachment. Eyes with CSC showed statistically significantly lower cMP-1 sensitivity and lower, but not significantly, pMP-1 sensitivity than control eyes (Po0.001, P ¼ 0.11, respectively). Eyes with CSC were not significantly different from control eyes in fixation location (P ¼ 1.00) or fixation stability (P ¼ 0.91). Fixation location was predominantly central in all eyes with CSC; fixation was stable in 12 (80%) and relatively unstable in 3 (20%). Conclusion Our study shows that eyes with resolved CSC can have lower retinal sensitivity in the central macula than control eyes, even after good VA has been obtained.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy

Özdemir

Karacorlu

Şentürk

et al. 2006

Eye

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“…There is a general understanding of epidemiology, pathology, and natural history through various studies, but most of these answers have remained theories rather than proven facts. [1][2][3][4][5] Some remain symptom free because of subclinical attack of ICSC. When patients return years later with visual deterioration and fundal changes often to a different ophthalmologist, difficulty arises as to whether the lesion has progressed or if there is a new superimposed pathology.…”

Section: Introductionmentioning

confidence: 99%

Five to 15 year follow-up of resolved idiopathic central serous chorioretinopathy

Wong

Chopdar

Brown

2004

Eye

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Purpose To recognize the long-term sequelae of resolved idiopathic central serous chorioretinopathy (ICSC) in relation to visual acuity, contrast sensitivity, and lesion size between time elapsed since disease onset. Methods Patients were recruited from fluorescein angiogram records between January 1985 and December 1995 with confirmed ICSC. Visual acuity, contrast sensitivity, and digital fundus photographs were recorded on follow-up. Comparison with the initial red-free photographs were made. Results There was no statistically significant deterioration of visual acuity over time compared to eyes with ICSC after initial resolution and the normal eyes. The change of lesion size over time was also statistically insignificant. Contrast sensitivity compared to visual acuity showed positive correlation in both ICSC and normal eyes, but the results were statistically insignificant. Lesion size correlates negatively with visual acuity and contrast sensitivity although this was statistically insignificant. Conclusion This study shows little, if any, correlation between time and progression of retinal pigment epitheliopathy following resolution of ICSC. Visual acuity did not seem to worsen over time. Our data were not statistically significant, but it does give insight into the natural history of what is still a relatively poorly understood disease.

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“…The lower the threshold, the better the overall cone function within the tested field. This psychophysical analysis of photoreceptor function has been used and validated in the assessment macular function in central serous retinopathy 12 and age-related macular degeneration. 13 Overlay of the central OCT field on the central 9 Â 9 degree field of the fine matrix map (after appropriate scaling and adjustment) was performed to evaluate corresponding retinal thickness and the associated cone function, and the changes in these parameters after PPV.…”

Section: Methodsmentioning

confidence: 99%

Pars plana vitrectomy for diabetic macular oedema: OCT and functional correlations

Patel

Hykin

Schadt

et al. 2005

Eye

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Purpose A prospective study to evaluate the macular structural and functional effects of pars plana vitrectomy (PPV) for persistent diffuse clinically significant macular oedema (CSMO). Method A total of 12 patients with persistent diffuse CSMO were recruited and underwent assessment including best-corrected visual acuity, fundus fluorescein angiography, optical coherence tomography (OCT) and fine matrix mapping (FMM) at baseline and over a period of a year poststandard three-port PPV. Results The median baseline ETDRS letters score for all 12 patients was 52 (range 41-63) while at 12 months it had increased to 65 (range of 27-68), an improvement of two complete ETDRS lines (P ¼ 0.037). Similarly, there was an improvement in the perifoveal cone thresholds (P ¼ 0.02). The foveal thickening for all 12 patients ranged from a median of 183 to 751 lm (normal range 126-180 lm) and the macular volume ranged from a median of 2.13 to 6.42 mm 3 (normal o1.66 mm 3 ). After surgery, both the median foveal thickness (from 334 to 280 lm) and median macular volume (from 3.24 to 2.61 mm 3 ) demonstrated decreases over 12 months (P ¼ 0.01). On baseline OCT, the patients fell into two anatomically distinct groups: Group 1 (n ¼ 4) had a dome-shaped thickened macula with a partial posterior hyaloid separation and a significantly higher foveal thickness and macular volume than Group 2 (n ¼ 8) which had a diffuse lowelevation profile of the thickened macula (P ¼ 0.007).

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Retinal dysfunction in central serous retinopathy

Cited by 65 publications

References 10 publications

Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy

Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy

Five to 15 year follow-up of resolved idiopathic central serous chorioretinopathy

Pars plana vitrectomy for diabetic macular oedema: OCT and functional correlations

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