Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy

Özdemir, Hakan; Karacorlu, Serra; Şentürk, Fevzi; Karaçorlu, Murat; Uysal, Ömer

doi:10.1038/sj.eye.6702563

Cited by 81 publications

(69 citation statements)

References 15 publications

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“…13,14 The usefulness of microperimetry (MP) in evaluating retinal sensitivity (RS) and central retinal field function is well known in resolved CSC. [15][16][17][18][19][20][21][22][23][24] Although most MP evaluations of RS in patients after CSC resolution have used the MP-1 Microperimeter (Nidek Technologies, Padova, Italy), [15][16][17][18][19][20][21][22][23][24] this microperimeter presents MP values on a confocal scanning laser ophthalmoscope (cSLO) image without producing an optical coherence tomography (OCT) image. Therefore, direct comparisons between RS and retinal changes at a corresponding point are not possible.…”

Section: Introductionmentioning

confidence: 99%

Retinal sensitivity assessed by microperimetry and corresponding retinal structure and thickness in resolved central serous chorioretinopathy

Chung

et al. 2014

Eye

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Purpose To investigate the relationship between retinal sensitivity (RS) assessed by microperimetry (MP) and retinal structural changes in patients with resolved central serous chorioretinopathy (CSC). Methods Spectral domain optical coherence tomography (OCT) examination and MP tests were performed in patients with resolved CSC. Point-to-point correlation was performed between RS and corresponding retinal structural changes using Pearson's correlation analysis. In addition, in a 1-mm zone in the central fovea, a correlation was calculated between the mean RS and the mean central retinal thickness (CRT). Results Eighty-four eyes were analyzed. The total number of MP test points was 1092 (84 eyes Â 13 points). The mean RS and retinal point thickness (RPT) of all test points were 13.53±3.84 dB and 208.6±48.0 mm, respectively. The RS and RPT were significantly decreased in the test points with loss of the ellipsoid portion of the inner segments (EPIS) (Po0.0001). Within the 1-mm foveal center zone, there was a significant correlation between mean RS and mean CRT (r ¼ 0.432, Po0.0001) and between RS and the corresponding RPT (r ¼ 0.339, Po0.0001). Conclusion RS was dependent on the status of the EPIS in patients with resolved CSC. The correlation between mean RS and mean CRT was compatible with the point-topoint correlation between RS and the corresponding RPT.

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Section: Introductionmentioning

confidence: 99%

Retinal sensitivity assessed by microperimetry and corresponding retinal structure and thickness in resolved central serous chorioretinopathy

Chung

et al. 2014

Eye

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“…Studies with microperimetry in eyes with CSC show significantly lower RS not only at the central but also in the paracentral area of the macula [29][30][31][32]. Furthermore, Ozdemir et al [33] found that eyes with resolved CSC had a statistically significant reduced central RS compared with controls. Although many studies have shown improvement in visual function after PDT [29][30][31][32], the improvement in BCVA may not be accompanied by an improvement in central RS.…”

Section: Discussionmentioning

confidence: 95%

Long-term chorioretinal changes after photodynamic therapy for chronic central serous chorioretinopathy

Vasconcelos

Marques

Santos

et al. 2013

Graefes Arch Clin Exp Ophthalmol

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Purpose To evaluate morphological and functional chorioretinal changes 5 years after standard photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC). Methods A retrospective, nonrandomized study, including patients with chronic CSC treated with standard PDT and followed for at least 60 months. All patients underwent a complete ophthalmological examination, and the location and number of treatments were registered. Five or more years after treatment, subfoveal and non-subfoveal treated areas were evaluated with Spectralis optical coherence tomography and microperimetry. Results Seventeen eyes of 15 patients were included, with mean age of 48.3±8.4 years and a mean follow-up of 80.6± 12.4 months (range from 62 to 104 months). All eyes had neurosensory detachment (NSD) at baseline. Treatment was performed under the fovea in 58.8 % and in a non-foveal area in 41.2 % of the eyes. At the final visit all eyes had resolution of the NSD, with a statistical significant reduction in central macular thickness (p=0.005) and preserved neuroretinal thickness (p=0.839). There was a statistical difference between initial and final BCVA (p<0.001) and a mean gain of 8.4±7.8 letters. Subfoveal morphological changes in external limiting membrane (ELM) and in photoreceptor inner and outer segment junction (IS/OS) were correlated with final BCVA (p=0.015 and p=0.014 respectively), but not with the variation of BCVA. There was a statistical correlation between morphological changes in IS/OS line and retinal sensitivity in the central 12°and 2°(p=0.003 and p=0.002 respectively). The morphological changes in the subfoveal layers were not dependent on treatment location (p=0.154, p=0.644, and p=1.0 for ELM, IS/OS line, and retinal pigment epithelium respectively). Subfoveal final mean choroidal thickness was 295.1±68.7 μm, and showed no statistical difference from the normal population (p=0.633). Conclusions Morphological and functional chorioretinal changes, observed 5 or more years after standard PDT for chronic CSC, were not correlated with the location of treatment, neither with the progression of visual acuity or with the location of treatment, and are more likely to be related to the disease itself than with the treatment provided.

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“…Evaluation of location and stability of fixation by MP-1 was previously reported in some macular diseases such as age-related macular degeneration and central serous retinopathy. 6,11 Previous studies have shown that fixation stability was significantly decreased in diabetic patients compared with control subjects, particularly in eyes with CSME. 7,9 Kube et al 9 detected that fixation stability was significantly decreased in diabetic patients in comparison to control with scanning laser ophthalmoscopy (SLO).…”

Section: Discussionmentioning

confidence: 99%

Diabetik Makula Ödeminde MP-1 Mikroperimetri ile Fiksasyon Stabilitesi ve Makuler Duyarlılığın Değerlendirilmesi

Küsbeci¹,

Yavaş²,

İnan³

2012

Tjo

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Sum maryPur po se: To evaluate macular light sensitivity and fixation stability in subjects with clinically significant macular edema (CSME) related to diabetes mellitus. Ma te ri al and Met hod: Thirty eyes of 22 patients with CSME, as defined by Early Treatment Diabetic Retinopathy Study, and 32 eyes of 32 healthy subjects were enrolled in this study. Microperimetry was performed with the Micro Perimeter MP-1 in both groups. The mean retinal sensitivities at central 4°, at central 12° and at central 20° were measured. The mean extent of preferred retinal locus (PRL), fixation stability and fixation location were calculated using fixation test in MP-1 microperimeter. Statistical analysis was performed using student t-test and chisquare test. Re sults: The mean best-corrected visual acuity (BCVA) was significantly lower in the CSME group than the control group (p<0.001). The mean retinal sensitivities at central 4°, 12° and 20° areas were significantly lower in the CSME group compared to the control group (p<0.001, for each central degrees). In subjects with CSME, fixation stability was detected as stable in 8 (26.7%) eyes, relatively unstable in 21 (70%) eyes and unstable in 1 (3.3%) eye. Significant decrease was found in fixation stability and fixation location scores in eyes with CSME compared to control subjects (p<0.001). The difference of mean extent in PRL between the groups was statistically significant (p<0.001). Dis cus si on: The macular light sensitivity and fixation stability are affected in patients with CSME. MP-1 micropeimetry might be helpful to evaluate the extent of PRL and useful for evaluation of severity and progression of diabetic macular edema. (Turk J Ophthalmol 2012; 42: 310-5) Key Words: Clinically significant macular edema, fixation stability, MP-1 microperimetry, preferred retinal locus Özet Amaç: Diabetes mellitusa bağlı klinik olarak anlamlı makula ödemi (KAMÖ) olgularında fiksasyon stabilitesi ve makula ışık duyarlılığını değerlendirmek. Ge reç ve Yön tem: Diabetik Retinopati Erken Tedavi Çalışması tanı kriterlerine göre klinik olarak anlamlı makula ödemli 22 olgunun 30 gözü ve sağlıklı 32 olgunun 32 gözü çalışmaya dahil edildi. Tüm olgulara Micro Perimeter MP-1 ile mikroperimetri uygulandı. Santral 4, 12 ve 20 derecelik alanlarda ortalama retinal duyarlılık ölçüldü. MP-1 mikroperimetrede fiksasyon testi kullanılarak tercih edilen retinal alan (TERA) genişliği, fiksasyon stabilitesi ve alanı hesaplandı. Student t testi ve ki kare testi kullanılarak istatistiksel analiz yapıldı. So nuç lar: KAMÖ grubunda ortalama en iyi düzeltilmiş görme keskinliği (EDGK) kontrol grubuna göre anlamlı olarak düşüktü (p<0,001). KAMÖ grubunda santral 4, 12 ve 20 derecelik alanlarda ortalama retinal duyarlılık kontrol grubuna göre anlamlı olarak daha düşüktü (p<0,001, her derece için). KAMÖ olgularında fiksasyon stabilitesi, 8 (%26,7) gözde stabil, 21 (%70) gözde rölatif stabil ve 1 (%3,3) gözde unstabil olarak saptandı. KAMÖ'li gözlerde kontrol grubuna gore fiksasyon stabilesi ve fiksasyon alan skorla...

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Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy

Cited by 81 publications

References 15 publications

Retinal sensitivity assessed by microperimetry and corresponding retinal structure and thickness in resolved central serous chorioretinopathy

Retinal sensitivity assessed by microperimetry and corresponding retinal structure and thickness in resolved central serous chorioretinopathy

Long-term chorioretinal changes after photodynamic therapy for chronic central serous chorioretinopathy

Diabetik Makula Ödeminde MP-1 Mikroperimetri ile Fiksasyon Stabilitesi ve Makuler Duyarlılığın Değerlendirilmesi

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