Retinal artery occlusion followed by contralateral amaurosis fugax in association with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

Reddy, Amit K.; Lau, Marisa; Sieck, Erin G.; Kolfenbach, Jason R.; Palestine, Alan G.

doi:10.1016/j.ajoc.2020.100683

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…In cohort descriptions of patients with EGPA, ocular involvement is reported in up to 20% of cases, and this compromise is divided into orbital inflammation and ischemic vasculitis phenomena (Table 1). 7,9,10…”

Section: Discussionmentioning

confidence: 99%

“…1,8 In cohort descriptions of patients with EGPA, ocular involvement is reported in up to 20% of cases, and this compromise is divided into orbital inflammation and ischemic vasculitis phenomena (Table 1). 7,9,10 The orbital inflammatory compromise represents 80% of the eye manifestations, with conjunctival nodules (40%), orbital myositis (25%), and dacryoadenitis (10%) as the more frequent forms, while scleritis occurs in less than 4% of cases. 3,4,11 For this reason, the occlusive compromise of retinal vessels, optic neuropathy, and especially pseudotumors or granulomas of the orbit are common in the reported cases.…”

Section: Discussionmentioning

confidence: 99%

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Necrotizing Scleritis as a Manifestation of Eosinophilic Granulomatosis With Polyangiitis: A Case Report

Arenas-Beltran

Velandía

2023

Clin Med Insights Case Rep

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Eosinophilic granulomatosis with polyangiitis (EGPA) is an ANCA-associated vasculitis characterized by the development of necrotizing granulomas rich in eosinophils and vasculitis of small and medium vessels, with compromise of the respiratory tract, peripheral nervous system, and least frequent ocular involvement. We report the case of a 54-year-old Caucasian man with a history of EGPA who presented ocular pain, red eye, vision loss, and evidence of scleral slimming compatible with necrotizing scleritis. The patient was treated with systemic steroids and cyclophosphamide, which reduced the ocular pain but did not improve visual acuity, needing surgical treatment of the scleral coverage defect. While necrotizing scleritis is an unusual manifestation of EGPA, it should be part of the differential diagnosis in patients with red eye or ocular pain as an accurate diagnosis and prompt treatment could reduce local complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Necrotizing Scleritis as a Manifestation of Eosinophilic Granulomatosis With Polyangiitis: A Case Report

Arenas-Beltran

Velandía

2023

Clin Med Insights Case Rep

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“…Thus far, 17 cases of EGPA presenting with CRAO have been reported (3,(5)(6)(7)(8)(9); however, no case developed vasculitis symptoms during treatment with an anti-IL-5 receptor monoclonal antibody. Improvement in visual acuity was obtained in only four cases (5)(6)(7). Three of those four cases were treated immediately with a combination of steroid pulse therapy and cyclophosphamide.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Granulomatosis with Polyangiitis Presenting with Central Retinal Artery Occlusion During Treatment with Anti-interleukin-5 Receptor Monoclonal Antibody

et al. 2021

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Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophilic cytoplasm antibody (ANCA)associated vasculitis characterized by asthma and eosinophilia. Although EGPA involves multiple organs, ocular involvement is infrequent and often carries a poor visual prognosis. We herein report a rare case of EGPA presenting with central retinal artery occlusion (CRAO) in which visual loss developed during treatment with anti-interleukin (IL)-5 receptor monoclonal antibody, and improvement in visual outcomes was attained after treatment combining high-dose oral corticosteroids, cyclophosphamide and an anticoagulant. Physicians should consider CRAO as an ophthalmic manifestation of EGPA in patients with severe eosinophilic asthma.

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“…As in the other diseases of this group, conjunctivitis, episcleritis, scleritis, and PUK are the more common manifestations of eosinophilic GPA [77]. Amaurosis fugax, retinal artery occlusions, ischemic optic neuropathy, dacryoadenitis, and orbital inflammation have been described [78][79][80][81][82][83].…”

Section: Microscopic Polyangiitis This Subtype Characteristically Pre...mentioning

confidence: 99%

Systemic Vasculitis and Its Association with the Eye

Carreño¹,

Olivas-Vergara²

2023

Ophthalmologica

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Vasculitis are a group of diseases characterize by the inflammation of the blood vessel walls. They are classified according to the size of the main vessel involved: in large vessel, medium vessel, and small vessel vasculitis. Ophthalmic manifestations are quite common in most of these diseases. Being episcleritis and scleritis the most prevalent manifestation of vasculitis. However, there are certain ocular diseases especially characteristic of specific vasculitis entities. Given the severity and potential life-threat of these diseases, knowledge of the ocular manifestations is mandatory for the ophthalmologists.

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Retinal artery occlusion followed by contralateral amaurosis fugax in association with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

Cited by 7 publications

References 9 publications

Necrotizing Scleritis as a Manifestation of Eosinophilic Granulomatosis With Polyangiitis: A Case Report

Necrotizing Scleritis as a Manifestation of Eosinophilic Granulomatosis With Polyangiitis: A Case Report

Eosinophilic Granulomatosis with Polyangiitis Presenting with Central Retinal Artery Occlusion During Treatment with Anti-interleukin-5 Receptor Monoclonal Antibody

Systemic Vasculitis and Its Association with the Eye

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