Retinal and choroidal alterations in patients with anorexia nervosa without vision loss

Moschos, Marilita M.; Moustafa, Giannis-Aimant; Gonidakis, Fragiskos; Papageorgiou, Costas

doi:10.1002/eat.22471

Cited by 11 publications

(10 citation statements)

References 31 publications

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“…Only two studies evaluating ERG in the context of eating disorders met our inclusion criteria [58, 59]. Nasser et al [58] discussed oral food stimulation in the setting of binge eating, while the study by Moschos et al [59] discussed anorexia nervosa.…”

Section: Resultsmentioning

confidence: 99%

Electroretinography in psychiatry: A systematic literature review

et al. 2019

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This review aims to consolidate the available information on use of electroretinography as a diagnostic tool in psychiatry. The electroretinogram (ERG) has been found to have diagnostic utility in cocaine withdrawal (reduced light-adapted b-wave response), major depressive disorder (reduced contrast gain in pattern ERG), and schizophrenia (reduced a- and b-wave amplitudes). This review examines these findings as well as the applicability of ERG to substance use disorder, Alzheimer’s disease, autism spectrum disorder, panic disorder, eating disorders, attention deficit hyperactivity disorder, and medication use. While there have been promising results, current research suffers from a lack of specificity. Further research that quantifies anomalies in ERG present in psychiatric illness is needed.

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Section: Resultsmentioning

confidence: 99%

Electroretinography in psychiatry: A systematic literature review

et al. 2019

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“…No significant difference was found in the two studies in patients with Major depressive disorder [17,18]. In another study with 13 women with Anorexia nervosa, the macular thickness was found to be decreased in anorexia cases, while no difference was found in RNFL thickness between groups [19].…”

Section: Discussionmentioning

confidence: 85%

“…As a result of a meta-analysis of case-control studies related to this issue and performed in 2018, it was stated that RNFL can be used as a diagnostic tool in schizophrenia [16]. In addition to studies about schizophrenia, there are researches that ocular findings have been evaluated by using OCT in patients with Major depressive disorder, ADHD and Anorexia nervosa [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Retinal nerve fiber layer, macular thickness and anterior segment measurements in attention deficit and hyperactivity disorder

Ayyıldız

2019

Psychiatry and Clinical Psychopharmacology

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AIM: We aimed to explore whether there is difference in terms of Retinal Nerve Fiber Layer (RNFL) thickness, macula thickness and anterior segment structures of the eye between children and adolescents with ADHD and healthy controls. METHOD: Children and adolescents aged 8-16 years who were admitted to the Child Psychiatry outpatient clinic of Ahi Evran University Hospital diagnosed with ADHD constituted the study group. Exclusion criteria included patients who had any systemic/ocular or psychiatric disorder other than ADHD and patients who had any psychopharmacological treatment. Participants in the control group were children and adolescents who applied to the outpatient clinic of Ophthalmology at the same hospital with no chronic medical or psychiatric disorder. Groups were compared in terms of central macular thickness, retinal nerve fibre layer thickness (RNFL), central corneal thickness, corneal diameter, mean corneal radius of curvature, anterior chamber depth, and axial length using Optical Coherence Tomography (OCT) and Optical Biometry. RESULTS: Data obtained from the measurements of 60 eyes of 30 patients with ADHD and 60 eyes of 30 patients of the control group were evaluated. Groups were similar in terms of age and gender. Corneal thickness (p = 0.001) and axial length (p = 0.04) values were significantly higher in ADHD group while the mean corneal curvature radius (p = 0.03) was significantly lower in ADHD group than in controls. No significant difference was observed between groups in terms of RNFL thickness, macular thickness, the corneal diameter, and anterior chamber depth measurements. CONCLUSION: In recent years, the use of OCT in neuropsychiatric diseases has increased the interest in identifying possible biomarkers and the elucidation of neurodegenerative and neurodevelopmental mechanisms that contribute to the nature of these diseases. Differences in the ophthalmic anatomical structures observed between healthy controls and cases with ADHD, which is a neurodevelopmental disorder, need to be supported by longitudinal studies with a larger sample and using OCT in connection with brain imaging.

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“…These findings were also found to be related to BMI at presentation and duration of disease, RNFL thickness being negatively correlated to both. 102 In addition, patients with different subtypes of AN, namely restrictive AN and purge type AN, exhibited differences in overall retinal thickness of the macula, values being higher in the restrictive type which indicates that the anatomical impairment of the fovea maybe greater in the purge type AN. These findings suggest that OCT can help us understand the pathophysiology and ocular effects of AN, a subject that is currently poorly understood.…”

Section: Review Of Diseasesmentioning

confidence: 98%

The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review

Mukherjee

Al-Fahad²,

Elsherbiny³

2019

Ophthalmol Eye Dis

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Optical coherence tomography is designed to evaluate in vivo qualitative and quantitative changes of the anterior segment, optic nerve and the retina. Initial applications of this technology were confined mainly to ophthalmic diseases. However recently, numerous studies have evaluated its use in systemic conditions and in therapeutics where, optic nerve and retinal architecture can be assessed to monitor progression of systemic conditions and its response to treatment. This is a narrative review aimed at evaluating the debate surrounding the role of spectral domain optical coherence tomography, in systemic conditions where optic nerve affection can be measured and be used in the diagnosis, monitoring and assessment of treatment effect as a non-invasive, quick, novel technique.

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Retinal and choroidal alterations in patients with anorexia nervosa without vision loss

Abstract: In AN patients, even without vision loss, significant changes occur in retinal and choroidal thickness, as well as in the electrical activity of the macula. However, this is a pilot study in a small sample that needs replication.

Cited by 11 publications

References 31 publications

Electroretinography in psychiatry: A systematic literature review

Electroretinography in psychiatry: A systematic literature review

Retinal nerve fiber layer, macular thickness and anterior segment measurements in attention deficit and hyperactivity disorder

The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review

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