Retina-simulating phantom for optical coherence tomography

Baxi, Jigesh; Calhoun, William; Sepah, Yasir J.; Hammer, Daniel X.; Ilev, Ilko K.; Pfefer, T. Joshua; Nguyen, Quan Dong; Agrawal, Anant

doi:10.1117/1.jbo.19.2.021106

Cited by 59 publications

(58 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The difficulty in creating realistic bladder phantoms stems largely from the limitations of currently used materials (e.g., PDMS [17][18][19], PVA-C [20][21][22], latex [13]) and fabrication techniques (e.g., lathe-spinning [14], painting [13], and spin-coating [17,23]) for phantom creation. Importantly, with the emergence and clear clinical utility of multi-modality imaging technologies (e.g., WLC+OCT and WLC+BLC) it is also crucial for such phantoms to exhibit properties visible with multiple modalities.…”

Section: Introductionmentioning

confidence: 99%

Multimodal 3D cancer-mimicking optical phantom

Smith¹,

Lurie²,

Zlatev³

et al. 2016

Biomed. Opt. Express

View full text Add to dashboard Cite

Three-dimensional (3D) organ-mimicking phantoms provide realistic imaging environments for testing various aspects of optical systems, including for evaluating new probe designs, characterizing the diagnostic potential of new technologies, and assessing novel image processing algorithms prior to validation in real tissue. We introduce and characterize the use of a new material, Dragon Skin (Smooth-On Inc.), and fabrication technique, air-brushing, for fabrication of a 3D phantom that mimics the appearance of a real organ under multiple imaging modalities. We demonstrate the utility of the material and technique by fabricating the first 3D, hollow bladder phantom with realistic normal and multi-stage pathology features suitable for endoscopic detection using the gold standard imaging technique, white light cystoscopy (WLC), as well as the complementary imaging modalities of optical coherence tomography and blue light cystoscopy, which are aimed at improving the sensitivity and specificity of WLC to bladder cancer detection. The flexibility of the material and technique used for phantom construction allowed for the representation of a wide range of diseased tissue states, ranging from inflammation (benign) to high-grade cancerous lesions. Such phantoms can serve as important tools for trainee education and evaluation of new endoscopic instrumentation.

show abstract

Section: Introductionmentioning

confidence: 99%

Multimodal 3D cancer-mimicking optical phantom

Smith¹,

Lurie²,

Zlatev³

et al. 2016

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…However, the clinical relevance of these results may be questionable due to the lack of biologically relevant morphology. In recent studies, there have been increasing efforts to develop tissue phantoms with more complex morphology that can provide insights into clinical issues, such as the effect of device and tissue parameters on performance in measuring diagnostic parameters 3,4 (e.g., spatial dimensions of tissue structures indicative of disease onset/progression). These approaches may also provide more useful methods for guiding device development and enabling objective device performance assessment and intercomparison.…”

Section: Introductionmentioning

confidence: 99%

Rapid prototyping of biomimetic vascular phantoms for hyperspectral reflectance imaging

et al. 2015

View full text Add to dashboard Cite

Abstract. The emerging technique of rapid prototyping with three-dimensional (3-D) printers provides a simple yet revolutionary method for fabricating objects with arbitrary geometry. The use of 3-D printing for generating morphologically biomimetic tissue phantoms based on medical images represents a potentially major advance over existing phantom approaches. Toward the goal of image-defined phantoms, we converted a segmented fundus image of the human retina into a matrix format and edited it to achieve a geometry suitable for printing. Phantoms with vessel-simulating channels were then printed using a photoreactive resin providing biologically relevant turbidity, as determined by spectrophotometry. The morphology of printed vessels was validated by xray microcomputed tomography. Channels were filled with hemoglobin (Hb) solutions undergoing desaturation, and phantoms were imaged with a near-infrared hyperspectral reflectance imaging system. Additionally, a phantom was printed incorporating two disjoint vascular networks at different depths, each filled with Hb solutions at different saturation levels. Light propagation effects noted during these measurements-including the influence of vessel density and depth on Hb concentration and saturation estimates, and the effect of wavelength on vessel visualization depth-were evaluated. Overall, our findings indicated that 3-D-printed biomimetic phantoms hold significant potential as realistic and practical tools for elucidating light-tissue interactions and characterizing biophotonic system performance. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

“…In this case, OCT is used to measure the nerve's fiber layer thickness. According to Baxi et al [9], the variability and nonrepeatability of measurements using various OCT instruments demonstrates the need for a controlled test object (i.e., an eye phantom). The authors presented a retina-mimicking phantom, which incorporates all retinal layers visible with current OCT systems.…”

Section: Eye Phantom State Of the Artmentioning

confidence: 99%

Efficient Objective Metric Tool for Medical Electrical Device Development: Eye Phantom for Glaucoma Diagnosis Device

et al. 2017

View full text Add to dashboard Cite

Developing electronic medical devices is challenging. Simulations or in vivo experiments are not sufficient to obtain pertinent comparisons between potential design options. This paper presents a new artificial tool allowing objective comparisons between electronic device topologies. The main idea is to build a tool which is sensitive to targeted biological parameters only. These tools are generally called phantoms. The phantom presented in this paper is dedicated to IntraOcular Pressure (IOP) Measurement devices used in glaucoma diagnosis and treatment. It is called Biomechanical Eye Emulator (BEE). The BEE emulates the main biomechanical parameters influencing the IOP measurements. Because it is not sensitive to the living context, the BEE is the most efficient tool to investigate the best sensor design. BEE specifications are defined to be as close as possible to chosen models (humans or animals). Its efficiency is shown with a case study on rabbits. The results clearly demonstrate the BEE phantoms efficacy in providing objective assessment metrics during the sensor design process.

show abstract

Retina-simulating phantom for optical coherence tomography

Cited by 59 publications

References 24 publications

Multimodal 3D cancer-mimicking optical phantom

Multimodal 3D cancer-mimicking optical phantom

Rapid prototyping of biomimetic vascular phantoms for hyperspectral reflectance imaging

Efficient Objective Metric Tool for Medical Electrical Device Development: Eye Phantom for Glaucoma Diagnosis Device

Contact Info

Product

Resources

About