Retina Implant — A BioMEMS Challenge

Meyer, J.-U.

doi:10.1007/978-3-642-59497-7_3

Cited by 12 publications

(13 citation statements)

References 9 publications

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“…In normal retina, the photoreceptors modulate the released neurotransmitters in response to light, and stimulate the bipolar cell layers, which in turn stimulate the ganglion cell layer that possess axonal extensions leading all the way to the visual cortex of brain [9]. Thus, the loss of photoreceptors in retina due to diseases such as ARMD and RP renders the retina incapable of detecting visual information.…”

Section: System Operationmentioning

confidence: 99%

Ultra-high responsivity, silicon nanowire photodetectors for retinal prosthesis

Lee

Jung

Park

et al. 2012

2012 IEEE 25th International Conference on Micro Electro Mechanical Systems (MEMS)

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In this paper, a novel silicon nanowire photodetector on a flexible substrate is presented for replacing the function of photoreceptors in the retina to restore vision for the blind. An extremely high surface-to-volume-ratio characteristic of nanowire is capable of developing highly-sensitive photonic sensors. Therefore, a nanowire photodetector can be used as a stand-alone visual perception device without an external camera. The nanowire photodetector is first fabricated on a rigid substrate, and then transferred to a flexible substrate to fit the curvature of an eyeball. Experimental results using the fabricated silicon nanowire photodetector show very high photosensitivity and photoresponsivity for a wide range of light intensities and wavelengths. Mechanical bending tests are performed, and the results show that the optical performance of the flexible photodetector is well-preserved after repeated bending of 200 times. The presented performance evaluation results indicate the first viable alternative to using a camera for image acquisition.978-1-4673-0325-5/12/$31.00 ©2012 IEEE

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Section: System Operationmentioning

confidence: 99%

Ultra-high responsivity, silicon nanowire photodetectors for retinal prosthesis

Lee

Jung

Park

et al. 2012

2012 IEEE 25th International Conference on Micro Electro Mechanical Systems (MEMS)

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“…Despite enormous efforts and advances in clinical treatment of eye diseases there is no established method to prevent or cure degenerative processes in eyes. Recent advances in microtechnologies have paved the way to pursue the idea for developing a technical device that substitutes degenerated visual photoreceptors and neural structures for stimulating intact neural tissue in a way that a meaningful visual sensation is obtained [3]. Manuscript Motivated by the success of cochlear implants for deaf patients, scientists are now facing the challenge of creating a prosthetic visual system for the blind [4].…”

Section: Introductionmentioning

confidence: 99%

Development of Flexible Neural Microelectode Arrays Based on Parylene for Retinal Prosthesis

Xing

et al. 2008

2008 IEEE International Conference on Networking, Sensing and Control

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Microelectrode arrays (MEAs) have become key components in retinal implants for recording of neural signals or electrical stimulation of nerves. In this paper, implantable flexible MEAs based on a novel polymer, parylene, were developed by designing MEMS process. And electrical performance of prepared microelectrodes was characterized electrochemically. Results showed that impedance and phase delay of testing MEAs were 2000 QA100 Q and -20°from 103Hz to 105 Hz, respectively, which would supply a better application with neural interface for retinal prosthesis.

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“…In addition, PI has been reported to be nontoxic, with few or no complications when implanted into the body. Several multichannel flexible PI electrodes have been developed for diverse applications; including the brain machine interface (BMI) for the prosthesis, hearing aid, artificial vision for the blind, and body area network (Stieglitz et al 1997;Meyer 2002;Cheung et al 2007;Choi et al 2007;Patil and Turner 2008;Moon et al 2010). The general process of fabricating PI electrodes consists of (1) deposition of sacrificial layer (Al, SiO 2 ) on the substrate;…”

Section: Introductionmentioning

confidence: 99%

A dry release of polyimide electrodes using Kapton film and application to EEG signal measurements

et al. 2010

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We describe here a simple and novel method to fabricate polyimide (PI) electrodes without a complex process to release completed PI electrodes from the substrates after full-curing process. We separated the PI electrodes from the Si-wafer prior to full-curing process, and these non full-cured electrodes were placed between the Kapton films, and we performed full-curing process with these sandwiched electrodes. Then, PI electrodes were easily and clearly released from the substrate without the sacrificial layers. We assessed the mechanical properties of fabricated electrodes comparing with non full-cured PI electrodes to investigate the full-curing effect between Kapton films. The electrical property was evaluated by measuring the impedance. Testing of the cyto-toxicity of full-cured electrodes using human mesenchymal stem cells (hMSCs) and mouse fibroblasts (L929) was carried out and the electrodes fabricated by proposed method were nontoxic and could be used as implantable electrodes. We also found that the electrodes, uniformly spread on the surface of mouse skulls while maintaining close contact, could successfully measure multichannel EEG signals.

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Retina Implant — A BioMEMS Challenge

Cited by 12 publications

References 9 publications

Ultra-high responsivity, silicon nanowire photodetectors for retinal prosthesis

Ultra-high responsivity, silicon nanowire photodetectors for retinal prosthesis

Development of Flexible Neural Microelectode Arrays Based on Parylene for Retinal Prosthesis

A dry release of polyimide electrodes using Kapton film and application to EEG signal measurements

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