Retina and Optic Nerve

Adams, Samuel T.

doi:10.1001/archopht.1963.00960040648019

Cited by 18 publications

(2 citation statements)

References 346 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mammalian retina is a complex tissue composed of neuronal, glial, and vascular cell types among which retinal ganglion cells (RGCs) are the only type of output neurons that send their axons to the visual cortex of the brain [1]. It is now well established that the crosstalk between RGCs and different retinal cell types is critical for RGC survival [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Microarray analysis of gene expression in adult retinal ganglion cells

et al. 2005

View full text Add to dashboard Cite

Retinal ganglion cells (RGCs) transfer visual information to the brain and are known to be susceptible to selective degeneration in various neuropathies such as glaucoma. This selective vulnerability suggests that these highly specialized neurons possess a distinct gene expression profile that becomes altered by neuropathy-associated stresses, which lead to the RGC death. In this study, to identify genes expressed predominantly in adult RGCs, a global transcriptional profile of purified primary RGCs has been compared to that of the whole retina. To avoid alterations of the original gene expression profile by cell culture conditions, we isolated RNA directly from adult RGCs purified by immunopanning without prior sub-cultivation. Genes expressed predominantly in RGCs included: Nrg1, Rgn, 14-3-3 family (Ywhah, Ywhaz, Ywhab), Nrn1, Gap43, Vsnl1, Rgs4. Some of these genes may serve as novel markers for these neurons. Our analysis revealed enrichment in genes controlling the pro-survival pathways in RGCs as compared to other retinal cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Microarray analysis of gene expression in adult retinal ganglion cells

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Whilst hyperacuity tasks are processed at higher levels of the visual cortex, a healthy retina (Watkins 1991) and optic nerve are necessary to transmit visual information ot visual cortex. Neuronal degeneration in the retinal ganglion cell layer and retinal nerve fiber layer is one of the earlies changes in diabetic retinopathy (Bloodworth 1962) and these degenerative changes are independet of vascular changes (Adams 1963). Since the retinal ganglion cells and their axons carry the sampled retinal image information it is understandable that OMDT are raised in NIDDM.…”

Section: Discussionmentioning

confidence: 99%

Visual dysfunction in type II diabetic patients revealed by a hyperacuity test

Watkins

Buckingham

1992

Acta Ophthalmologica

View full text Add to dashboard Cite

Displacement thresholds for an oscillating bar, which fall into the hyperacuity range, were determined in 21 subjects with non-insulin dependent diabetes mellitus and 19 age-matched visually normal controls. The diabetic subjects were classed as either having minimal or no retinopathy. Whilst thresholds for the diabetic group were significantly raised above those of the normal group, there were no significant differences in thresholds between the diabetic subgroup with retinopathy and the subgroup without. Greater thresholds tended to be found at higher frequencies of oscillation as the known duration of the diabetes increased.

show abstract

Experimental Investigation of the Morphogenesis of Chloroquine Retinopathy

Meier‐Ruge¹

1965

Archives of Ophthalmology

View full text Add to dashboard Cite

Retina and Optic Nerve

Cited by 18 publications

References 346 publications

Microarray analysis of gene expression in adult retinal ganglion cells

Microarray analysis of gene expression in adult retinal ganglion cells

Visual dysfunction in type II diabetic patients revealed by a hyperacuity test

Experimental Investigation of the Morphogenesis of Chloroquine Retinopathy

Contact Info

Product

Resources

About