Reticulohistiocytosis

Luz, Flávio Barbosa; Kurizky, Patrícia Shu; Ramos‐e‐Silva, Márcia

doi:10.1016/j.det.2007.06.015

Cited by 9 publications

(10 citation statements)

References 50 publications

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“…Upon elution of the high‐abundance proteins from the column 24 unspecific proteins were sequestered to different extents and from these 11 were undetectable from the flowthrough, and therefore lost for subsequent proteomic analysis. Some of these proteins like calgranulin A 49, 50, lysozyme C 51, 52, and galectin 7 53, 54 are of high clinical interest. Some low‐abundance proteins may adhere to HSA and be partially removed during HSA depletion 55.…”

Section: Discussionmentioning

confidence: 99%

Quantitative assessment of human serum high‐abundance protein depletion

et al. 2008

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The aim of this study is to quantify the effectivity of the depletion of human high-abundance serum and plasma proteins for improved protein identification and disease marker candidate discovery and to assess the risk of concomitant removal of relevant marker proteins. 2-DE and bottom-up shotgun MS combining 2-D capillary chromatography with MS/MS were applied in parallel for the analysis of fractions resulting from the depletion procedure. For many proteins the factors of enrichment by the depletion were obvious allowing their enhanced detection and identification upon high-abundance protein depletion. Nano-liquid chromatography linked MS allowed the efficient identification of several low-abundant proteins that were not identified on the 2-DE gels. Resolving the fractions that were eluted from the matrix upon depletion indicated unspecific binding of disease relevant proteins in plasma samples from acute myocardial infarction patients. The unspecific binding to the depletion matrix of inflammatory markers spiked into the serum was found to depend on the type of capturing agent used. Polyclonal avian antibodies (IgY) displayed the least unspecific binding due to the high immunogenicity of mammalian proteins in avian hosts.

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Section: Discussionmentioning

confidence: 99%

Quantitative assessment of human serum high‐abundance protein depletion

et al. 2008

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“…SCR differs from conventional granulomatous inflammation by being free of well-formed spherical granulomas and the presence of large epithelioid histiocytes with eosinophilic “glassy” cytoplasm [4]. The last feature is unique and common in SCR [2]. …”

Section: Discussionmentioning

confidence: 99%

“…Other differential diagnoses include nodular tenosynovitis, fibrolipoma, Spitz's nevus, mastocytoma, keratoacanthoma, Hashimoto, and Pritzker's disease and pyogenic granuloma [2, 3]. These differential diagnoses were ruled out by the typical eosinophilic “glassy” cytoplasm and immunohistochemical study.…”

Section: Discussionmentioning

confidence: 99%

“…Despite being known since the 1950s its origin is still unknown. However, it is considered a nonneoplastic lesion, reactive, that originates by proliferation and differentiation of an anomalous histiocytic clone [2]. Still, regarding the etiology of the lesion, its development has already being related to traumatic areas, but the majority of cases appear spontaneously [3].…”

Section: Introductionmentioning

confidence: 99%

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A Unique Dermoscopy Pattern of Solitary Cutaneous Reticulohistiocytosis

Oliveira¹,

Nogueira²,

Chaves³

et al. 2013

Case Reports in Dermatological Medicine

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Histiocytosis represents a group of rare disorders characterized by nonneoplastic proliferation of histiocytes and solitary cutaneous reticulohistiocytosis (SCR) is a form of non-Langerhans histiocytosis. SCR consists of small papule, usually single, varying in color from yellow to brownish-red, more frequent in young adults, and uncommon in childhood. We report a case of SCR in an 11-year-old child and emphasize a unique dermoscopy pattern of this lesion and its correlation with clinical and histopathological aspects in the diagnosis.

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“…Dear Editor , Reticulohistiocytoma and multiple cutaneous reticulohistiocytosis (MCRH) are benign, possibly reactive, histiocytic proliferations of the skin or soft tissues, and are usually not associated with any systemic disease . Reticulohistiocytoma is a cutaneous condition that presents as a solitary, firm, dermal subcentimetre skin lesion.…”

Section: Differential Diagnosis Of Reticulohistiocytoma and Expected mentioning

confidence: 99%