Reticulo-endothelial function in rats with obstructive jaundice

Tanaka, Nobutaka; Rydén, Stefan; Bergqvist, Lennart; Christensen, Poul; Bengmark, S

doi:10.1002/bjs.1800721204

Cited by 45 publications

(16 citation statements)

References 19 publications

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“…The change was much stronger than in group I and thus can not only be related to the operative procedure. It confirms the study of Tanaka et al [19] who showed a decrease in the liver uptake 1 week after bile duct occlu--Before obstruction (R = 11.7) = 6 days after biliary obstruction (R = 5.1) Fig. 6.…”

Section: Discussionsupporting

confidence: 81%

Dynamic Liver Scintigraphy: A New Way of Measuring the Function of the Reticulo-endothelial System of the Liver

Baas

Senninger²,

Elser³

et al. 1995

Eur Surg Res

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The phagocytic function and biokinetics of the hepatic reticuloendothelial system (RES) were evaluated using a 25-nm diameter colloid (Nanocoll^TM) and a scintillation camera technique in opossums with obstruction of the pancreatic duct (group I) and additional obstruction of the common bile duct (group II). The liver net uptake curve was analysed using natural log regression. The regression curves proved to fit very well (r > 0.93) and a parameter R was calculated to describe the curves. In group I there was a slight but significant decrease in the RES function and no morphological change in the pancreas. In group II, RES function was significantly more suppressed than in group I. The opossums developed severe haemorrhagic pancreatitis. The results show that the regression parameter R is well suited to describe liver RES function, and suggest that a suppressed liver RES after biliary obstruction could be an important factor in the pathogenesis of biliary pancreatitis.

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Section: Discussionsupporting

confidence: 81%

Dynamic Liver Scintigraphy: A New Way of Measuring the Function of the Reticulo-endothelial System of the Liver

Baas

Senninger²,

Elser³

et al. 1995

Eur Surg Res

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“…On the other hand, prolonged biliary obstruction in the rat impairs the host defence system by depression of the reticuloendothelial system phagocytic activity [4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Effect of Different Enteral Nutrients on Bacterial Translocation in Experimental Obstructive Jaundice

Kuru¹,

Dinç²,

Altınok

et al. 2004

Eur Surg Res

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Obstructive jaundice leads to bacterial translocation (BT) by disruption of the gut barrier, intestinal microecology, and impaired host immune defence. The objective of the present study is to investigate the effects of different enteral nutrients on BT that is induced by obstructive jaundice in rats. Eighty male Wistar-Albino rats were randomly assigned into 4 groups. Group 1: 20 rats underwent laparotomy, common bile duct (CBD) was not actually ligated and transected, but sham ligation of CBD was performed. Groups 2–4: 60 rats underwent laparotomy, CBD ligation and transection. Group 1 and 2 rats were given rat chow, group 3 rats were fed a glutamine and arginine supplemented enteral diet, and group 4 rats were fed an arginine, m-RNA and ω-3 supplemented enteral diet, an immunonutrient. Rats in groups 3 and 4 had significantly less BT to mesenteric lymph nodes compared to rats in group 2 (p = 0.001). These findings suggest that oral administration of an arginine and glutamine supplemented diet and immunonutrition reduce BT in rats with obstructive jaundice.

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“…13,14 Inadequate clearance of endotoxins in obstructive jaundice has been attributed to an altered reticuloendothelial system (RES) function of Kuppfer cells in the liver. 14,15 Recently, it has been demonstrated that, in isolated liver Kuppfer cells from cholestatic mice, increased numbers of viable intracellular bacteria after infection were present, suggesting an impaired intracellular bacterial killing. 16 The exact consequence with respect to development of infectious complications remains to be elucidated.…”

Section: Experimental Studiesmentioning

confidence: 99%

Preoperative Biliary Drainage in Patients with Obstructive Jaundice: History and Current Status

Gaag

Kloek

Castro

et al. 2009

Journal of Gastrointestinal Surgery

157

114

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Rationale Preoperative biliary drainage (PBD) has been introduced to improve outcome after surgery in patients suffering from obstructive jaundice due to a potentially resectable proximal or distal bile duct/pancreatic head lesion. In experimental models, PBD is almost exclusively associated with beneficial results: improved liver function and nutritional status; reduction of systemic endotoxemia; cytokine release; and, as a result, an improved immune response. Mortality was significantly reduced in these animal models. Human studies show conflicting results. Findings For distal obstruction, currently the "best-evidence" available clearly shows that routine PBD does not yield the appreciated improvement in postoperative morbidity and mortality in patients undergoing resection. Moreover, PBD harbors its own complications. However, most of the available data are outdated or suffer from methodological deficits. Conclusion The highest level of evidence for PBD to be performed in proximal obstruction, as well as over the preferred mode, is lacking but, nevertheless, assimilated in the treatment algorithm for many centers. Logistics and waiting lists, although sometimes inevitable, could be factors that might influence the decision to opt for PBD, as well as an extended diagnostic workup with laparoscopy (on indication) or scheduled preoperative chemotherapy.

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Reticulo-endothelial function in rats with obstructive jaundice

Cited by 45 publications

References 19 publications

Dynamic Liver Scintigraphy: A New Way of Measuring the Function of the Reticulo-endothelial System of the Liver

Dynamic Liver Scintigraphy: A New Way of Measuring the Function of the Reticulo-endothelial System of the Liver

Effect of Different Enteral Nutrients on Bacterial Translocation in Experimental Obstructive Jaundice

Preoperative Biliary Drainage in Patients with Obstructive Jaundice: History and Current Status

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